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Glutathione

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Definition: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.     
Examples Glutathione Disulfide; Phytochelatins; S-Nitrosoglutathione 		Other names Glutathione, Reduced; gamma-L-Glutamyl-L-Cysteinylglycine; gamma-L-Glu-L-Cys-Gly; Reduced Glutathione; gamma L Glutamyl L Cysteinylglycine; gamma L Glu L Cys Gly
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
methylarsenic diglutathione  0   *Arsenicals Glutathione/*analogs & derivatives. J Biol Chem. 2000 Oct 27;275(43):33404-8.
glutathione-C4  0   Glutathione/*analogs & derivatives Influenza A virus/drug effects. Antioxid Redox Signal. 2011 Aug 1;15(3):593-606
7-S-glutathione-aminochrome  0   *Indoles Glutathione/*analogs & derivatives. Neurochem Res 2010 Nov;35(11):1805-18
carbamathione  0   Glutathione/*analogs & derivatives. J Pharm Biomed Anal 2010 Jan 5;51(1):186-91
mefenamic acid glutathione thioester  0   Glutathione/*analogs & derivatives Mefenamic Acid/*analogs & derivatives. J Pharm Biomed Anal 2010 Jan 5;51(1):164-9
ethacrynic acid glutathione thioether  0   Ethacrynic Acid/*analogs & derivatives Glutathione/*analogs & derivatives. J Pharm Biomed Anal 2010 Jan 5;51(1):164-9
TLK-236  0   Glutathione/*analogs & derivatives. Blood. 2009 Jun 25;113(26):6533-40
poly(ethylene glycol)-glutathione conjugate  0   *Polyethylene Glycols Glutathione/*analogs & derivatives. Biomacromolecules 2009 Jan 12;10(1):155-61
4-S-glutathionyl-4-methylpentan-2-one  0   *Pentanones Glutathione/*analogs & derivatives. J Agric Food Chem 2009 Feb 11;57(3):991-5
ibuprofen-S-acyl-glutathione  0   Glutathione/*analogs & derivatives Ibuprofen/*analogs & derivatives. Chem Res Toxicol. 2008 Sep;21(9):1749-59
S-palmitoleoylglutathione  0   *Palmitates Glutathione/*analogs & derivatives. Free Radic Biol Med 2008 Apr 15;44(8):1624-36
S-lauroylglutathione  0   *Laurates Glutathione/*analogs & derivatives. Free Radic Biol Med 2008 Apr 15;44(8):1624-36
4-methoxy-1-tyrosyl-gamma-glutamyl-cysteinyl-glycine  0   Glutathione/*analogs & derivatives. Int J Cardiol 2008 Mar 28;125(1):133-5
S-(4-nitrophenacyl)glutathione  0   Glutathione/*analogs & derivatives. Anal Biochem. 2008 Mar 1;374(1):25-30
glutathione C(60)-fullerene complex  0   *Fullerenes Glutathione/*analogs & derivatives. Neurosci Lett 2007 Dec 18;429(2-3):81-6
glutathionyl-1,4-dihydroxynonane  0   Glutathione/*analogs & derivatives. Cancer Res 2006 Oct 1;66(19):9705-13
glutathionyl 4-hydroxy-2-nonenal conjugate  0   Glutathione/*analogs & derivatives. Cancer Res 2006 Oct 1;66(19):9705-13
N-tBoc L-glutathione di-tert-butyl ester  0   Glutathione/*analogs & derivatives. Bioorg Med Chem. 2007 Jan 15;15(2):1062-6
N-tBoc L-glutathione dimethyl ester  0   Glutathione/*analogs & derivatives. Bioorg Med Chem. 2007 Jan 15;15(2):1062-6
S-(dimethylarsino)-glutathione  0   *Arsenicals Glutathione/*analogs & derivatives. Toxicology 2006 Oct 3;227(1-2):45-52
dehydroglutathione  0   Glutathione/*analogs & derivatives. Biochem J 2006 Oct 1;399(1):161-8
gamma-(gamma-oxa)glutamyl-(9-fluorenylmethyl)-cysteinyl-glycine  0   *Fluorenes Glutathione/*analogs & derivatives Glutathione Transferase/antagonists & inhibitors. Amino Acids 2005 Nov;29(3):255-61
gamma-glutamyl-(9-fluorenylmethyl)-cysteinyl-glycine  0   *Fluorenes Glutathione/*analogs & derivatives Glutathione Transferase/antagonists & inhibitors. Amino Acids 2005 Nov;29(3):255-61
methylenediphenyl diisocyanate-glutathione adduct  0   *Benzhydryl Compounds Glutathione/*analogs & derivatives Biological Markers. Toxicology 2006 May 15;222(3):202-12
glutathione sulfinamide  0   Glutathione/*analogs & derivatives. Chem Biol Interact 2003 Feb 1;143-44:175-81
N-1-deoxyfructos-1-yl glutathione  0   Fructose/*analogs & derivatives Glutathione/*analogs & derivatives. Biochim Biophys Acta 2005 Jun 20;1724(1-2):181-93
4'-hydroxy-2'-glutathion-deschloro-diclofenac  0   Diclofenac/*analogs & derivatives Glutathione/*analogs & derivatives. Drug Metab Dispos. 2005 Apr;33(4):484-8
(glutathion-S-yl)-1,4-benzoquinone  0   Glutathione/*analogs & derivatives. Chem Res Toxicol 2005 Jan;18(1):41-50
RayGel  0   *Anthocyanins *Glutathione Drug Combinations. Am J Surg 2005 May;189(5):627-30; discussion 630-1
menadione-S-glutathione conjugate  0   Glutathione/*analogs & derivatives Vitamin K 3/*analogs & derivatives. Proc Natl Acad Sci U S A 2004 Dec 21;101(51):17582-7
diclofenac-S-acyl-glutathione  0   Diclofenac/*analogs & derivatives Glutathione/*analogs & derivatives. Chem Res Toxicol 2003 Nov;16(11):1410-7
S-(2,3-dichlorotriazinyl)glutathione  0   Glutathione/*analogs & derivatives. Eur J Biochem. 2004 Sep;271(17):3503-11
PELF protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Glutathione Epirubicin Levoleucovorin. Br J Cancer 2004 Apr 19;90(8):1521-5
1,4-phenylenebis(methylene)selenocyanate, glutathione conjugate  0   *Organoselenium Compounds Glutathione/*analogs & derivatives. Carcinogenesis 2003 Sep;24(9):1505-14
dinitrosotrypanothione  0   *Nitroso Compounds Glutathione/*analogs & derivatives. Biochem J 2003 Apr 1;371(Pt 1):49-59
glutathionesulfonic acid sodium salt  0   Glutathione/*analogs & derivatives. Biol Pharm Bull 2002 Jun;25(6):761-5
S-decylglutathione  0   Glutathione/*analogs & derivatives. Eur J Biochem 2002 Jul;269(14):3470-8
S-3-(hexan-1-ol)gluathione  0   Glutathione/*analogs & derivatives. J Agric Food Chem 2002 Jul 3;50(14):4076-9
S-(4-chlorophenylcarbamoyl)glutathione  0   *Sulfonylurea Compounds Glutathione/*analogs & derivatives Glutathione Reductase/antagonists & inhibitors. Drug Metab Dispos 2002 Mar;30(3):331-5
clofibryl-acyl-glutathione  0   Glutathione/*analogs & derivatives. Chem Res Toxicol 2001 Aug;14(8):1033-40
glutathione-doxorubicin conjugate  0   Doxorubicin/*analogs & derivatives Glutathione/*analogs & derivatives. Anticancer Drugs 2001 Jul;12(6):549-54
S-(1-acetoxymethyl)glutathione  0   Glutathione/*analogs & derivatives. Chem Res Toxicol 2001 May;14(5):600-8
N'-(glutathion-S-yl)-N-acetylbenzidine S-oxide  0   *Benzidines Glutathione/*analogs & derivatives. Drug Metab Dispos 2001 Apr;29(4 Pt 1):401-6
glutathione sulfonamide  0   *Sulfones Glutathione/*analogs & derivatives. J Biol Chem 2001 Jun 22;276(25):22120-5
4-(N-(S-glutathionylacetyl)amino)phenylarsenoxide  0   *Arsenicals Glutathione/*analogs & derivatives. Protein Sci 2000 Dec;9(12):2436-45
glutathione mustard  0   Glutathione/*analogs & derivatives. Carcinogenesis 1980;1(12):1049-57
FOG7 chemotactic  0   *Glutathione *Arachidonic Acid. J Biol Chem 2000 Sep 29;275(39):29931-4
6-glutathionylquercetin  0   Quercetin/*analogs & derivatives Glutathione. Arch Biochem Biophys 2000 Jun 15;378(2):224-33
8-glutathionylquercetin  0   Quercetin/*analogs & derivatives Glutathione. Arch Biochem Biophys 2000 Jun 15;378(2):224-33
glutathione-1,4-dihydroxynonene conjugate  0   *Alkenes Glutathione. Toxicol Lett 2000 Apr 3;114(1-3):203-14
glutathionyl hemoglobin  0   *Glutathione *Hemoglobins. Clin Chem 2000 Jan;46(1):82-8
dinitrosylbis(glutathione)iron(II)  0   *Ferrous Compounds Glutathione/*analogs & derivatives. Free Radic Res 1999 Dec;31(6):525-34
homoglutathione  0   Glutathione/*analogs & derivatives. Plant Physiol 1999 Nov;121(3):753-61
S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione  0   Glutathione/*analogs & derivatives. Structure Fold Des 1999 Sep 15;7(9):1067-78
S-(N-hydroxy-N-p-iodophenylcarbamoyl)glutathione  0   Glutathione/analogs & derivatives Lactoylglutathione Lyase/antagonists & inhibitors. Biochemistry 1999 Oct 12;38(41):13480-90
S-(5-(4-benzoylphenyl)pentyl)glutathione  0   Glutathione/*analogs & derivatives. Bioorg Med Chem Lett 1999 Sep 20;9(18):2661-6
Recancostat compositum  0   *Anthocyanins *Cysteine *Glutathione Drug Combinations. Klin Padiatr 1999 Jul-Aug;211(4):353-5
adriamycin-glutathione adduct  0   *Doxorubicin *Glutathione. Anticancer Res 1999 May-Jun;19(3A):1909-18
glutathionyl-3-hydroxykynurenine glucoside  0   Glutathione Kynurenine. J Biol Chem 1999 Jul 23;274(30):20847-54
S-(N-4-chlorophenyl-N--hydroxycarbamoyl)glutathione dicyclopentyl ester  0   Glutathione/*analogs & derivatives.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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