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Morpholines

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Definition:      
Examples Dextromoramide; Molsidomine; Moricizine; Morpholinos; Phenmetrazine; Timolol; Viloxazine; Xamoterol 		Other names Tetrahydro-1,4-Oxazines; Tetrahydro 1,4 Oxazines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MPI-0479605  0   *Morpholines Adenine/*analogs & derivatives. Mol Cancer Ther. 2011 Dec;10(12):2267-75.
3-(2,3-dihydro-1H-inden-2-yl)-1-(1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl)-6-(1-methylpropyl)-2,5-piperazinedione  0   *Morpholines *Diketopiperazines Oxytocin/antagonists & inhibitors. J Med Chem. 2012 Jan 26;55(2):783-96.
NVP-BKM120  0   *Aminopyridines *Morpholines Phosphatidylinositol 3-Kinase/antagonists & inhibitors. Sci Transl Med. 2010 Sep 29;2(51):51ra70.
GEBR-7b  0   *Imines *Morpholines Phosphodiesterase Inhibitors Cyclic Nucleotide Phosphodiesterases, Type 4. Br J Pharmacol. 2011 Dec;164(8):2054-63.
tas41 compound  0   *Alkaloids *Morpholines Antineoplastic Agents, Phytogenic. Environ Toxicol Pharmacol. 2011 May;31(3); 406-15
SHR116958  0   *Benzamides *Morpholines Gastrointestinal Agents. Pharmazie. 2011 Nov;66(11):826-30
preoxazinin-7  0   *Morpholines. Org Biomol Chem. 2011 Dec 7;9(23):7990-2
oxazinin-5  0   *Morpholines. Org Biomol Chem. 2011 Dec 7;9(23):7990-2
oxazinin-6  0   *Morpholines. Org Biomol Chem. 2011 Dec 7;9(23):7990-2
N3-(4-(4-morpholinocyclohexyl)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine  0   *Morpholines *Triazoles Proto-Oncogene Proteins c-kit/antagonists & inhibitors. J Med Chem. 2011 Oct 27;54(20):7184-92.
alpha-((5-fluoro-2-methoxyphenyl)methyl)-alpha-(tetrahydro-2H-pyran-4-yl)-2-morpholinemethanol  0   *Morpholines Phenylethyl Alcohol/*analogs & derivatives Adrenergic Uptake Inhibitors. J Psychiatr Res. 2011 Jun;45(6):748-55.
CDy1 compound  0   *Anthracenes *Morpholines Fluorescent Dyes. Nat Protoc. 2011 Jul;6(7):1044-5
N-(3-hydroxy-1-morpholino-4-(3-octylphenyl)butan-2-yl)tetradecanamide  0   *Morpholines *Myristates. Biochem Biophys Res Commun. 2011 Sep 23;413(2):159-63.
N-(4-(4-(morpholine-4-carbonyl)piperidine-1-yl)phenyl)-2-phenoxypyrimidine-5-carboxamide  0   *Morpholines *Pyrimidines. Prostaglandins Other Lipid Mediat. 2011 Aug;95(1-4):27-34.
2'-O-(1,1-dioxo-1lamda(6)-thiomorpholine-4-carbothioate)  0   *Morpholines *Sulfur Compounds. J Am Chem Soc. 2011 Aug 3;133(30):11540-56
4-morpholinecarboxaldehyde  0   *Morpholines. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1395-401
2-morpholin-7-(pyridin-2-ylmethoxy)-4H-naphth(2,1-e)-1,3-oxazin-4-one  0   *Morpholines *Oxazines. Bioorg Med Chem 2011 Jul 1;19(13):3983-94
3-(4-hydroxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one  0   *Morpholines 4-Butyrolactone/*analogs & derivatives Tyrosine-tRNA Ligase/antagonists & inhibitors. Bioorg Med Chem 2011 Jul 1;19(13):3884-91
((N-morpholine)metylene)daunorubicin  0   *Morpholines Daunorubicin/*analogs & derivatives Antibiotics, Antineoplastic. Acta Pol Pharm. 2011 Sep-Oct;68(5):759-63
N-(4-methylphenyl)-N',N'-bis(morpholinyl) phosphoric triamide  0   *Morpholines *Organophosphorus Compounds. Acta Crystallogr B. 2011 Jun;67(Pt 3):238-43
4-(4,6-di(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)-4-methylomorpholinium tetrafluoroborate  0   *Borates *Morpholines. J Org Chem. 2011 Jun 3;76(11):4506-13
3-((2-morpholinoethylimino)methyl)benzene-1,2-diol  0   *Morpholines. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jun;79(1):263-71
2-((2-iodophenoxy)phenylmethyl)morpholine  0   *Iodobenzenes *Morpholines Iodine Radioisotopes. Synapse 2011 Jul;65(7):658-67
N-(4-aminosulfonylphenyl)-2-morpholino-9H-purin-6-amine  0   *Morpholines *Purines. Bioorg Med Chem. 2010 Jul 1;18(13):4615-24
1-(2-(morpholin-4-yl)ethyl)-3-(4-(-3-(6-(morpholin-4-yl)pyridin- 2-yl)prop-2-enoyl)phenyl)urea dihydrochloride  0   *Morpholines *Pyridines Urea/*analogs & derivatives. Neuropharmacology. 2011 May;60(6):991-9
1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid morpholineamide  0   *Indoleacetic Acids *Morpholines Receptor, Cannabinoid, CB2/agonists. Prostaglandins Other Lipid Mediat 2011 Feb;94(1-2):17-24
2-(2-(3-hydroxymorpholin-4-yl)ethylthio)-5-ethoxybenzimidazole  0   *Benzimidazoles *Morpholines. Bull Exp Biol Med 2010 Sep;149(3):318-9
(2R)-6-methoxy-8-(4-methylpiperazin-1-yl)-N-(4-morpholin-4-ylphenyl)chromane-2-carboxamide  0   *Benzopyrans *Morpholines. Psychopharmacology (Berl). 2011 Feb;213(2-3):533-45
N-(3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1,4-benzoxazin-6-yl)-N-ethyl-N'-methylurea  0   *Methylurea Compounds *Morpholines Receptors, Adrenergic, alpha-2. J Pharmacol Exp Ther 2011 Apr;337(1):256-66
N-(morpholinyl)-1-(3-(trifluoromethyl)phenylamino)isoquinoline-4-carboxamide  0   *Isoquinolines *Morpholines Receptor, Cannabinoid, CB2/agonists. Bioorg Med Chem. 2011 Jan 15;19(2):939-50
3-(2-morpholino-6-(2-(pyridin-4-yl)ethylamino)pyrimidin-4-yl)phenol  0   *Morpholines *Phenols. Bioorg Med Chem. 2011 Jan 15;19(2):836-51
3-(4-morpholino-6-(pyridin-2-yl)pyrimidin-2-yl)phenol  0   *Morpholines *Phenols. Bioorg Med Chem. 2011 Jan 15;19(2):836-51
1-(1-(4-methylphenyl) (cyclohexyl)) morpholine  0   *Morpholines. Arzneimittelforschung. 2011;61(2):92-7
MRT67307  0   *Cyclobutanes *Morpholines. Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G253-63
4-(3,4-dichlorophenyl)-2-(2-(4-methylpiperazin-1-yl)benzylidene)thiomorpholin-3-one  0   *Morpholines *Piperazines Receptor, Serotonin, 5-HT1B. Drug Metab Dispos 2010 Nov;38(11):1984-99
RS-1269  0   *Benzamides *Morpholines Edema/drug therapy. Basic Clin Pharmacol Toxicol. 2010 Oct;107(4):793-7
N-(4'-dihydro)piperoylthiomorpholine  0   *Morpholines *Benzodioxoles. J Cardiovasc Pharmacol 2010 Sep;56(3):293-9
PF 592379  0   *Aminopyridines *Morpholines Receptors, Dopamine D3/agonists. Xenobiotica 2010 Nov;40(11):730-42
4-(4-hydroxy-3,5-bis(morpholin-4-ylmethyl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester  0   *Dihydropyridines *Morpholines. Eur J Med Chem 2010 Oct;45(10):4622-30
SSR 241586  0   *Morpholines. Org Lett. 2010 Aug 20;12(16):3693-5
5-(4-butoxy-3-chlorophenyl)-N-((2-morpholinopyridin-3-yl)methyl)nicotinamide  0   *Morpholines Niacinamide/*analogs & derivatives. Neuropharmacology 2010 Sep;59(3):201-7
2-methyl-4'-(methylthio)-2-morpholinopropiophenone  0   *Morpholines *Propiophenones. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2010 Jul;27(7):1040-9
4-(2-(dimethylamino)vinyl)-2-(3-hydroxyphenyl)-6-morpholinopyrimidine-5-carbonitrile  0   *Morpholines *Pyrimidines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Sep 1;334(3):830-8
AM6545  0   *Morpholines *Pyrazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Clin Invest. 2010 Aug 2;120(8):2953-66
KW-2478  0   *Morpholines HSP90 Heat-Shock Proteins/antagonists & inhibitors. Clin Cancer Res. 2010 May 15;16(10):2792-802
N-(4-nitrobenzoyl)-N',N'-bis(morpholino)phosphoric triamide  0   *Morpholines *Nitrobenzenes. Acta Crystallogr B. 2010 Aug;66(Pt 4):441-50
pyrimorph  0   *Acrylamides *Morpholines. J Agric Food Chem 2010 Mar 10;58(5):2720-5
3-O-(morpholino-beta-oxopropanoyl)-12beta-acetoxy-3alpha,25-dihydroxy-(20S,24R)-epoxydammarane  0   *Morpholines *Triterpenes. Bioorg Med Chem. 2010 Apr 15;18(8):2964-75
acortatarin B  0   *Morpholines *Spiro Compounds Alkaloids. Org Lett. 2010 Apr 16;12(8):1844-7
acortatarin A  0   *Morpholines *Spiro Compounds Alkaloids. Org Lett. 2010 Apr 16;12(8):1844-7
N-(imino(4-morpholyl)methyl)guanidine  0   *Guanidines *Morpholines. Bull Exp Biol Med 2009 Oct;148(4):619-22
5-tert-butyl-N-cyclopropyl-2-methoxy-3-(2-(4-(2-morpholin-4-ylethoxy)naphthalen-1-yl)-2-oxoacetylamino)benzamide  0   *Benzamides *Morpholines. Eur J Pharmacol 2010 Apr 25;632(1-3):93-102
3-isopropyloxy-6-morpholino-2-phenylphenalen-1-one  0   *Morpholines *Phenalenes. Appl Biochem Biotechnol 2010 Mar;160(6):1744-51
2-(4-dimethylaminophenyl)-5-fluoro-6-(morpholin-4-yl)-1H-benzimidazole  0   *Benzimidazoles *Morpholines. Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Oct;25(10):1618-21
1-(4-(4-(3-oxa-8-azabicyclo(3.2.1)octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea  0   *Morpholines Urea/*analogs & derivatives. J Org Chem. 2010 Mar 5;75(5):1643-51
LY 290042  0   *Chromones *Morpholines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Biochem Biophys Res Commun 2010 Apr 9;394(3):476-81
1-(4-((4-(Dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea  0   *Morpholines *Triazines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2010 Mar 25;53(6):2636-45
bis(morpholinium 2,4,6-trinitrocyclohexanolate)  0   *Cyclohexanes *Morpholines. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Feb;75(2):745-52
3-(2-(2-phenyl-4-(4-pyridin-4-ylbenzyl)morpholin-2-yl)ethyl)quinazoline-2,4(1H,3H)-dione  0   *Morpholines *Quinazolinones Receptors, CCR4/antagonists & inhibitors. Eur J Pharmacol 2009 Dec 10;624(1-3):38-44
(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol  0   *Morpholines. Cancer Res. 2010 Jan 1;70(1):288-98
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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