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Tyrosine-tRNA Ligase

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Definition: An enzyme that activates tyrosine with its specific transfer RNA. EC 6.1.1.1.      Other names Tyrosyl tRNA Synthetase; Tyrosine tRNA Ligase; Tyr tRNA Ligase; Synthetase, Tyrosyl-tRNA; Ligase, Tyrosine-tRNA; Ligase, Tyr-tRNA; Tyrosyl-tRNA Synthetase; Tyr-tRNA Ligase; Tyrosyl T RNA Synthetase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(4-hydroxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one  0   *Morpholines 4-Butyrolactone/*analogs & derivatives Tyrosine-tRNA Ligase/antagonists & inhibitors. Bioorg Med Chem 2011 Jul 1;19(13):3884-91
mini-TyrRS, human  EC 6.1.1.1   *Peptide Fragments *Tyrosine-tRNA Ligase. Proc Natl Acad Sci U S A 2002 NNov 26;99(24):15369-74
SB 243545  0   *Dipeptides *Piperidines Tyrosine-tRNA Ligase/antagonists & inhibitors. Protein Sci 2001 Oct;10(10):2008-16
SB 239629  0   *Dipeptides *Piperidines Tyrosine-tRNA Ligase/antagonists & inhibitors. Protein Sci 2001 Oct;10(10):2008-16
SB 227871  0   *Furans *Bicyclo Compounds, Heterocyclic Tyrosine-tRNA Ligase/antagonists & inhibitors. J Antibiot (Tokyo) 200 Apr;53(4):351-6
SB 219383  0   *Furans *Bicyclo Compounds, Heterocyclic Tyrosine-tRNA Ligase/antagonists & inhibitors. J Antibiot (Tokyo) 200 Apr;53(4):351-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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