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Dihydropyridines

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Definition: Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.     
Examples Amlodipine; Dicarbethoxydihydrocollidine; Felodipine; Isradipine; Nicardipine; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4,5-diethyl-3-(2-methoxyethylthio)-2-methyl-6-phenyl-1,4-dihydropyridine-3,5-dicarboxylate  0   *Dihydropyridines TRPV Cation Channels/agonists. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60
1-butyl-4-(1H-inden-1-ylidene)-1,4-dihydropyridine  0   *Dihydropyridines *Indenes. J Phys Chem A. 2010 Oct 7;114(39):10563-74
4-(4-hydroxy-3,5-bis(morpholin-4-ylmethyl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester  0   *Dihydropyridines *Morpholines. Eur J Med Chem 2010 Oct;45(10):4622-30
K-2-11 compound  0   *Dihydropyridines. Anticancer Res. 2010 Oct;30(10):4063-9
2,6-dimethyl-4-(3-O-benzyl-1,2-O-isopropylidene-beta-L-threo-pentofuranos-4-y)-1-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester  0   *Dihydropyridines *Glycosides. Exp Parasitol. 2009 Nov;123(3):258-64
diethyl 4-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarboxylate  0   *Dihydropyridines. Mycoses 2009 May;52(3):223-7
OSI-2954  0   *Dihydropyridines. Cell Biochem Funct 2004 Jul-Aug;22(4):219-24
OSI-1190  0   *Dihydropyridines. Cell Biochem Funct 2004 Jul-Aug;22(4):219-24
OSI 3802  0   *Dihydropyridines. Chem Biol Interact 2008 Jun 17;173(3):195-204
etaftoron  0   *Dihydropyridines. Chem Biol Interact 2008 Jun 17;173(3):195-204
OSI 1210  0   *Dihydropyridines. Chem Biol Interact 2008 Jun 17;173(3):195-204
3-(1-(2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl)-3,6-dihydro-2H-pyridin-4-yl)-6-chloro-1H-indole  0   *Dihydropyridines *Indoles Receptors, Dopamine D4/antagonists & inhibitors. Eur J Pharmacol 2007 Nov 14;573(1-3):148-60
Bay w 9798  0   *Dihydropyridines. J Int Med Res 2007 Nov-Dec;35(6):886-91
N-methyl-3-(tert-butyl)sulfinyl-1,4-dihydropyridine  0   *Dihydropyridines *Sulfoxides. Molecules 2007;12(3):415-22
3,5-dicyano-4-(5'-nitro-2'-furyl)-2,6-dimethyl-1,4-dihydropyridine  0   *Dihydropyridines *Nitrofurans. Bioelectrochemistry 2006 Sep;69(1):104-12
ethyl 4-(5'-nitro-2'-furyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate  0   *Dihydropyridines *Nitrofurans. Bioelectrochemistry 2006 Sep;69(1):104-12
monomethyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-2,5-dicarboxylate  0   *Dihydropyridines. Drug Metab Dispos 2006 May;34(5):734-7
DHP-014  0   *Dihydropyridines. Biopharm Drug Dispos 2005 Oct;26(7):279-85
sodium 3,5-bis-ethoxycarbonyl-2,6,dimethyl-1,4-dihydropyridine-4-carboxylate  0   *Dihydropyridines. Mutat Res 2005 Nov 10;587(1-2):52-8
9-(3-iodo-4-methylphenyl)-5,9-dihydro-3H-furo(3,4-b)pyrano(4,3-e)pyridine-1,8(4H,7H)-dione  0   *Dihydropyridines *Pyrones. J Cardiovasc Pharmacol 2005 Aug;46(2):232-40
(N-(4-(2-hydroxy-3-(1-(2-chlorophenyl)piperazinyl)propoxy)-3-methoxy)benzyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine  0   *Dihydropyridines *Piperazines. J Cardiovasc Pharmacol 2005 Aug;46(2):130-40
aspernigrin A  0   *Dihydropyridines. J Nat Prod 2005 Jul;68(7):1106-8
labedipinedilol A  0   *Anisoles *Dihydropyridines. J Cardiovasc Pharmacol 2004 Nov;44(5):539-51
3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine  0   *Dihydropyridines. Br J Pharmacol. 2004 Feb;141(3):415-22
LAU 0901  0   *Dihydropyridines. J Cataract Refract Surg 2004 Apr;30(4);884-91
desazadesferrithiocin  0   *Dihydropyridines *Thiazoles. Chirality. 2003 Aug;15(7):593-9
2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester  0   *Dihydropyridines. J Org Chem 2002 May 17;67(10):3499-501
ZD0947  0   *Dihydropyridines. J Urol 2002 Aug;168(2):837-42
BMS 193885  0   *Dihydropyridines *Phenylurea Compounds Receptors, Neuropeptide Y/antagonists & inhibitors. Bioorg Med Chem Lett 2002 Feb 11;12(3):379-82
dimethyl-4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate  0   *Dicarboxylic Acids *Dihydropyridines. J Appl Physiol 2002 Mar;92(3):997-1003
3-methyl 5-isopropyl 2-methoxyiminomethyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  0   *Dihydropyridines *Nitro Compounds. Acta Crystallogr C 2001 Sep;57(Pt 9):1073-4
N-(tert-butoxycarbonyl)-N-(4-(dimethylazaniumylidene)-1,4-dihydropyridin-1-ylsulfonyl)azanide  0   *Dihydropyridines. Org Lett 2001 Jul 12;3(14):2241-3
methylpentyl-1,4-dihydro-2,6-dimehtyl-4-(3-nitrophenyl)-3,5-pydridinedicarboxylate  0   *Dihydropyridines *Nitrobenzenes. Acta Pharmacol Sin 2000 Jul;21(7):623-6
BAY R3401  0   *Dihydropyridines *Furans. Diabetes 2000 Sep;49(9):1419-26
vanidipinedilol  0   *Dihydropyridines Receptors, Adrenergic, beta-2/agonists. J Cardiovasc Pharmacol 2000 Jan;35(1):51-63
dimethyl-1,4-dihydro-2,6-dimethyl-4-(4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl)-3,5-pyridine dicarboxylate  0   *Dihydropyridines. Farmaco 1999 Oct 30;54(10):660-5
diethyl 2,6-dimethyl-4-(5-(1-naphthylethyl)-3-methylisoxazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate  0   *Dihydropyridines *Isoxazoles. J Med Chem 1999 Aug 12;42(16):3087-93
FR 172516  0   *Dihydropyridines. J Cardiovasc Pharmacol 1999 Apr;33(4):587-94
fluodipine  0   *Dicarboxylic Acids *Dihydropyridines. Eur J Pharmacol 1998 Oct 23;359(2-3):161-70
SNAP 5540  0   *Dihydropyridines *Piperidines. J Med Chem 1998 Dec 17;41(26):5320-33
Sch 00013  0   *Dihydropyridines *Pyridazines. J Pharmacol Exp Ther 1998 Oct;287(1):214-22
PCA 50922  0   *Dihydropyridines. Brain Res 1998 Jun 15;796(1-2):311-4
L 762459  0   *Amidines *Dihydropyridines. Eur J Pharmacol 1998 May 8;348(2-3):287-95
N-methylammodendrine  0   *Dihydropyridines. J Nat Toxins 1998 Jun;7(2):131-40
N-acetylhystrine  0   *Dihydropyridines. J Nat Toxins 1998 Jun;7(2):131-40
desmethyldesferrithiocin  0   *Dihydropyridines *Thiazoles. Ann N Y Acad Sci 1998 Jun 30;850:202-16
CP 220629  0   *Pyrazoles *Dihydropyridines. J Med Chem 1998 Jun 18;41(13):2268-77
PCA 50938  0   *Dihydropyridines. Brain Res 1997 Oct 24;772(1-2):57-62
BAY 10-6735  0   *Dihydropyridines *Tetrazoles. Int J Clin Pharmacol Ther 1997 Oct;35(10):434-41
1-methyl-4-pentyl-1,4-dihydropyridine-3,5-dicarbaldehyde  0   *Aldehydes *Dihydropyridines. Biochemistry 1997 Dec 16;36(50):15765-71
BAY y 5959  0   *Dihydropyridines. J Am Coll Cardiol 1997 Dec;30(7):1751-7
embusartan  156001-18-2   *Dihydropyridines *Tetrazoles Receptor, Angiotensin, Type 1/antagonists & inhibitors Angiotensin II Type 1 Receptor Blockers. Arzneimittelforschung 1997 Sep;47(9):1016-23
MRS 1191  0   *Dihydropyridines. J Med Chem 1997 Aug 1;40(16):2596-608
2-hydroxypropylmethyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate  0   *Dihydropyridines. Naunyn Schmiedebergs Arch Pharmacol 1997 Jan;355(1):119-25
CGP-IOS  0   *Dihydropyridines. Gen Physiol Biophys 1996 Feb;15(1):37-50
AN 1043  0   *Dihydropyridines. J Biol Chem 1996 Sep 13;271(37):22358-67
AN 406  0   *Dihydropyridines. J Biol Chem 1996 Sep 13;271(37):22358-67
Z 6568  0   *Dihydropyridines *Phenoxypropanolamines. J Mass Spectrom 1996 Jan;31(1):37-46
AC 394  0   *Dihydropyridines. Cancer Chemother Pharmacol 1996;38(5):446-52
MRS 1097  0   *Dihydropyridines Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1996 Jul 19;39(15):2980-9
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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