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HSP90 Heat-Shock Proteins

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Definition: A class of MOLECULAR CHAPERONES whose members act in the mechanism of SIGNAL TRANSDUCTION by STEROID RECEPTORS.      Other names Heat-Shock Proteins, HSP90; Heat Shock Proteins 90; HSP90 Heat Shock Proteins; Heat-Shock Proteins 90
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one  0   *Pyridones *Pyrimidines HSP90 Heat-Shock Proteins/antagonists & inhibitors. Anticancer Res. 2012 Feb;32(2):453-62.
CH5164840  0   *Benzoquinones *Lactams, Macrocyclic Biotin HSP90 Heat-Shock Proteins/antagonists & inhibitors. Cancer Sci. 2012 Feb;103(2):342-9
5-(2,4-dihydroxy-5-isopropylphenyl)-4-(5-(morpholinomethyl)isoxazole-3-carbonylamino)isoxazole-3-carboxylic acid ethylamide  0   *Isoxazoles *Resorcinols HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem. 2011 Dec 22;54(24):8592-604.
N-(4-(3H-imidazo(4,5-c)pyridin-2-yl)-9H-fluoren-9-yl)-1H-pyrrolo(2,3-b)pyridine-4-carboxamide  0   *Fluorenes *Imidazoles HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem. 2011 Oct 27;54(20):7206-19.
2-amino-4-(4-chloro-2-(2-(4-fluoro-1H-pyrazol-1-yl)ethoxy)-6-methylphenyl)-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo(3,4-d)pyrimidine-6-carboxamide  0   *Pyrazoles *Pyrimidines HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2011 May 12;54(9):3368-85
2-(4-acetyloxycyclohexylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-benzamide  0   *Benzamides *Indazoles HSP90 Heat-Shock Proteins/antagonists & inhibitors. Bioorg Med Chem Lett 2011 Mar 15;21(6):1675-7
XL 888  0   *Phthalic Acids *Azabicyclo Compounds HSP90 Heat-Shock Proteins/antagonists & inhibitors. PLoS One 2011;6(3):e17692
hsp90alpha protein, Xenopus  0   *HSP90 Heat-Shock Proteins *Xenopus Proteins. Iran Biomed J. 2010 Oct;14(4):127-35
pochoxime A  0   *Lactones *Oximes HSP90 Heat-Shock Proteins/antagonists & inhibitors. Chembiochem 2009 Nov 23;10(17):2753-9
EC 144  0   *Pyrimidines *Pyrroles HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Immunol 2011 Jan 1;186(1):563-75
(4-(5-furan-2-yl-3-methyl-1H-pyrazol-4-yl)-butyl)methyl-(7H-purin-6-yl)amine  0   *Pyrazoles Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. ChemMedChem 2010 Oct 4;5(10):1697-700
(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone  0   *Benzamides *Isoindoles HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2010 Aug 26;53(16):5956-69
KW-2478  0   *Morpholines HSP90 Heat-Shock Proteins/antagonists & inhibitors. Clin Cancer Res. 2010 May 15;16(10):2792-802
TRAP1 protein, rat  0   *HSP90 Heat-Shock Proteins. FEBS J. 2010 Apr;277(8):1929-38
2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide  0   *Anthranilic Acids *Indoles HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Mar;332(3):849-57
TRAP-1 protein, mouse  0   *HSP90 Heat-Shock Proteins. Am J Pathol 2010 Jan;176(1):393-401
NVP-BEP800  0   *Pyrimidines HSP90 Heat-Shock Proteins/antagonists & inhibitors. Br J Haematol. 2009 Nov;147(3):319-27
STA-1474  0   *Triazoles HSP90 Heat-Shock Proteins/antagonists & inhibitors. Int J Cancer. 2009 Dec 15;125(12):2792-801
Hsp90-7 protein, Arabidopsis  0   *HSP90 Heat-Shock Proteins *Arabidopsis Proteins. Planta. 2009 Mar;229(4):955-64
Hsp90-5 protein, Arabidopsis  0   *HSP90 Heat-Shock Proteins *Arabidopsis Proteins. Planta. 2009 Mar;229(4):955-64
Hsp90-2 protein, Arabidopsis  0   *HSP90 Heat-Shock Proteins *Arabidopsis Proteins. Planta. 2009 Mar;229(4):955-64
SNX-7081  0   *Benzamides HSP90 Heat-Shock Proteins/antagonists & inhibitors. Arthritis Rheum 2008 Dec;58(12):3765-75
SNX 2112  0   *Heterocyclic Compounds with 4 or More Rings HSP90 Heat-Shock Proteins/antagonists & inhibitors. Blood 2009 Jan 22;113(4):846-55
HSP90alpha protein, human  0   *HSP90 Heat-Shock Proteins. Cancer Invest 2008 Nov;26(9):900-4
STA 9090  0   *Triazoles HSP90 Heat-Shock Proteins/antagonists & inhibitors. Exp Hematol 2008 Oct;36(10):1266-77
5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide  0   *Isoxazoles *Resorcinols HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2008 Jan 24;51(2):196-218
PU H71  0   *Purines *Benzodioxoles HSP90 Heat-Shock Proteins/antagonists & inhibitors. Cancer Res 2008 Jan 1;68(1):216-26
6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine  0   *Pyridines Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2767-78
6-chloro-9-(5-methoxy-4,6-dimethylpyridin-3-ylmethyl)-9H-purin-2-ylamine  0   *Pyridines Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2767-78
2-amino-6-chloro-9-(4-iodo-3,5-dimethylpyridin-2-ylmethyl)purine  0   *Pyridines Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2767-78
efungumab  0   *Antibodies, Monoclonal HSP90 Heat-Shock Proteins. Curr Opin Investig Drugs 2001 Apr;2(4):472-6
DAF-21 protein, C elegans  0   *HSP90 Heat-Shock Proteins *Caenorhabditis elegans Proteins Cell Cycle Proteins. Genetics 2000 May;155(1):85-104
9-(2-(2,2-dimethylpropylamino)ethyl)-8-(2-iodo-5-methoxyphenylsulfanyl)-9H-purin-6-ylamine  0   Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):817-28
8-(2-iodo-5-methoxyphenylsulfanyl)-9-(3-isopropylaminiopropyl)-9H-purin-6-ylamine  0   Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):817-28
9-(3-sec-butylaminopropyl)-8-(2-iodo-5-methoxyphenylsulfanyl)-9H-purin-6-ylamine  0   Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):817-28
EC5 compound  0   Rifabutin/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. Clin Cancer Res 2005 May 15;11(10):3889-96
8-demethylgeldanamycin  0   *Quinones HSP90 Heat-Shock Proteins. J Nat Prod 2005 Apr;68(4):607-10
9-(pent-4-ynyl)-8-(6-bromobenzo(1,3)dioxol-5-ylsulfanyl)adenine  0   Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2892-905
Hsp86 protein, human  0   *HSP90 Heat-Shock Proteins. Ann Pathol 2004 Oct;24(5):473-5
Hsp90-3 protein, Arabidopsis  0   *HSP90 Heat-Shock Proteins *Arabidopsis Proteins. J Exp Bot 2005 Feb;56(412):633-44
2-fluoro-8-((2-chloro-3,4,5,-trimethoxyphenyl)methyl)-9-pentyladenine  0   *Anisoles Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. Chem Biol 2004 Jun;11(6):787-97
9-(n-butyl)-8-((3,4,5-trimethoxyphenyl)methyl)adenine  0   *Anisoles Adenine/*analogs & derivatives Adenosine Triphosphatases/antagonists & inhibitors HSP90 Heat-Shock Proteins/antagonists & inhibitors. Chem Biol 2004 Jun;11(6):775-85
HSP90AB1 protein, human  0   *HSP90 Heat-Shock Proteins. J Biol Chem 2004 Oct 8;279(41):42545-51
Hsp90b1 protein, mouse  0   *HSP90 Heat-Shock Proteins.
HtpG protein, E coli  0   *HSP90 Heat-Shock Proteins *Escherichia coli Proteins.
HSP84 protein, mouse  0   *HSP90 Heat-Shock Proteins. FEBS Lett 2004 Jul 16;570(1-3):69-72
17-(3-aminopropylamino)-17-demethoxygeldanamycin  0   *Benzoquinones *Lactams, Macrocyclic HSP90 Heat-Shock Proteins. Cancer Res 2003 Nov 15;63(22):7876-82
Hsp90-1 protein, Arabidopsis  0   *HSP90 Heat-Shock Proteins *Arabidopsis Proteins. Plant Physiol 2002 Jul;129(3):1138-49
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin  0 ((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(2-dimethylaminoethylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo(16.3.1)docosa-4,6,10,18,21-pentaen-9-yl) carbamate  *Benzoquinones *Lactams, Macrocyclic HSP90 Heat-Shock Proteins. Cancer Chemother Pharmacol 2002 Jan;49(1):7-19
tacrolimus binding protein 5  EC 5.2.1.8   *Tacrolimus Binding Proteins HSP90 Heat-Shock Proteins.
tacrolimus binding protein 4  EC 5.2.1.-   *Tacrolimus Binding Proteins HSP90 Heat-Shock Proteins.
HSP90AA1 protein, human  0   *HSP90 Heat-Shock Proteins. Biochim Biophys Acta 1998 May 29;1398(1):18-24
17-(allylamino)-17-demethoxygeldanamycin  0 ((4E,6E,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo(16.3.1)docosa-4,6,10,18,21-pentaen-9-yl) carbamate  *Benzoquinones *Lactams, Macrocyclic Protein-Serine-Threonine Kinases/antagonists & inhibitors HSP90 Heat-Shock Proteins/antagonists & inhibitors. Cancer Res 1998 Jun 1;58(11):2385-96
MOD-E protein, Podospora anserina  0   *Fungal Proteins *HSP90 Heat-Shock Proteins. Genetics 1997 Oct;147(2):581-8
Hspca protein, mouse  0   *HSP90 Heat-Shock Proteins. Cell Stress Chaperones 1997 Jun;2(2):87-93
HSP81-3 protein, Arabidopsis  0   *HSP90 Heat-Shock Proteins *Arabidopsis Proteins. Plant Cell Physiol 1994 Dec;35(8):1207-19
TRAP1 protein, human  0   *HSP90 Heat-Shock Proteins. J Biol Chem 1995 Feb 24;270(8):3574-81; Mol Cell Biol. 1996 Sep;16(9):4691-9
Swo1 protein, S pombe  0   *HSP90 Heat-Shock Proteins *Schizosaccharomyces pombe Proteins. EMBO J 1994 Dec 15;13(24):6099-106
heat-shock protein 98  0   *DNA-Binding Proteins *HSP90 Heat-Shock Proteins. Biochim Biophys Acta 1992 Dec 8;1156(1):1-6
HSP82 protein, S cerevisiae  0   *HSP90 Heat-Shock Proteins *Saccharomyces cerevisiae Proteins. Biochim Biophys Acta 1992 May 7;1131(1):103-7
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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