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Protein-Serine-Threonine Kinases

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Definition: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.     
Examples Activin Receptors; AMP-Activated Protein Kinases; Bone Morphogenetic Protein Receptors; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Cyclic Nucleotide-Regulated Protein Kinases; Cyclin-Dependent Kinases; DNA-Activated Protein Kinase; eIF-2 Kinase; G-Protein-Coupled Receptor Kinases; Glycogen Synthase Kinases; I-kappa B Kinase; Interleukin-1 Receptor-Associated Kinases; Lim Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Oncogene Protein v-akt; p21-Activated Kinases; Phytochrome A; Positive Transcriptional Elongation Factor B; Proline-Directed Protein Kinases; Protein Kinase C; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcr; Proto-Oncogene Proteins c-pim-1; Receptor-Interacting Protein Serine-Threonine Kinases; rho-Associated Kinases; Ribosomal Protein S6 Kinases; TOR Serine-Threonine Kinases; Vacuolar Sorting Protein VPS15 		Other names Serine-Threonine Protein Kinases; Serine Threonine Protein Kinases; Serine Threonine Kinases; Serine Threonine Kinase; Protein Threonine Kinase; Protein Serine Threonine Kinases; Protein Serine Threonine Kinase; Protein Serine Kinase; Protein Kinases, Serine-Threonine; Kinases, Serine-Threonine Protein; Kinases, Serine-Threonine; Kinases, Protein-Serine-Threonine; Kinase, Threonine; Kinase, Serine-Threonine; Kinase, Serine; Kinase, Protein-Threonine; Kinase, Protein-Serine-Threonine; Kinase, Protein-Serine; Threonine Kinase; Serine-Threonine Kinases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ATM protein, Drosophila  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Drosophila Proteins Cell Cycle Proteins. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):E656-64.
Rio1 protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. FEBS Lett. 2002 Jul 31;524(1-3):31-6.
SIK3 protein, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Mol Cell Endocrinol. 2004 Mar 31;217(1-2):109-12.
BIR1 protein, Arabidopsis  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Arabidopsis Proteins. Plant J. 2011 Sep;67(6):1081-93.
Ulk4 protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Nat Genet. 2012 Jan;44(1):58-61.
polo-like kinase 2, C elegans  EC 2.7.1.37   *Protein-Serine-Threonine Kinases *Caenorhabditis elegans Proteins. Dev Cell. 2011 Nov 15;21(5):934-47
Goodpasture antigen-binding protein-1, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. J Biol Chem. 2011 Oct 7;286(40):35030-43.
EIP1 protein, Arabidopsis  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Arabidopsis Proteins. Plant Cell Physiol. 2011 Aug;52(8):1376-88.
CAST AWAY protein, Arabidopsis  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Arabidopsis Proteins. Plant Physiol 2011 Aug;156(4):1837-50
DCLK protein, Xenopus  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Xenopus Proteins Microtubule-Associated Proteins. Endocrinology 2011 Jun;152(6):2321-9
AAK1 protein, rat  EC 2.7.1.37   *Protein-Serine-Threonine Kinases. Chem Biol. 2011 Jul 29;18(7):891-906
DYF-18 protein, C elegans  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Caenorhabditis elegans Proteins. Dev Biol 2011 Sep 1;357(1):235-47
CoPK32 protein, Coprinopsis cinerea  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Biochim Biophys Acta. 2011 Jun;1810(6):620-9
LMTK3 protein, human  EC 2.7.11.1   *Membrane Proteins *Protein-Serine-Threonine Kinases. Nat Med. 2011 Jun;17(6):660-1
salt-inducible kinase 3, Drosophila  EC 2.7.1.-   *Protein-Serine-Threonine Kinases *Drosophila Proteins. Cell. 2011 May 13;145(4):596-606
polo-like kinase 4, Xenopus  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Xenopus Proteins. J Cell Biol 2010 Nov 15;191(4):721-9
Pto-interacting 1-4 kinase, Arabidopsis  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Arabidopsis Proteins. FEBS J 2011 Apr;278(7):1126-36
Pink1 protein, zebrafish  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. J Neurosci 2008 Aug 13;28(33):8199-207
CtkA protein, Helicobacter pylori  EC 2.7.11.1   *Bacterial Proteins *Protein-Serine-Threonine Kinases. Proc Natl Acad Sci U S A 2010 Dec 14;107(50):21418-23
KSR2 protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Mol Cell 2009 Jun 26;34(6):652-62
Hipk2 protein, zebrafish  EC 2.7.1.-   *Carrier Proteins *Protein-Serine-Threonine Kinases. Mol Cell Biol. 2011 Mar;31(5):955-70
ROP18 protein, Toxoplasma gondii  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. PLoS Biol 2010;8(12):e1000576
CG14217 protein, Drosophila  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Drosophila Proteins. J Neurosci. 2011 Jan 19;31(3):1139-48
Drak protein, Drosophila  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Drosophila Proteins. Mol Biol Cell 2010 Aug 15;21(16):2869-79
Nek10 protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Mol Cell Biol 2011 Jan;31(1):30-42
MASTL protein, human  EC 2.7.11.1   *Microtubule-Associated Proteins *Protein-Serine-Threonine Kinases. Cell Cycle 2010 Sep;9(17):3591-601
SRF3 protein, Arabidopsis  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Arabidopsis Proteins. Nat Genet 2010 Dec;42(12):1135-9
DDK protein, S pombe  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Schizosaccharomyces pombe Proteins. Mol Cell 2010 Nov 24;40(4):606-18
Pknk protein, Mycobacterium tuberculosis  EC 2.7.11.1   *Bacterial Proteins *Protein-Serine-Threonine Kinases. Microbiology 2010 Sep;156(Pt 9):2829-41
TNIK protein, rat  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. J Neurosci 2010 Nov 3;30(44):14786-94
FASTKD3 protein, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Biochem Biophys Res Commun. 2010 Oct 22;401(3):440-6
FASTKD3 protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Biochem Biophys Res Commun. 2010 Oct 22;401(3):440-6
CDKL3 protein, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Neurobiol Dis 2010 Sep;39(3):242-51
SNARK protein, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15541-6
Hrk1 protein, S pombe  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Schizosaccharomyces pombe Proteins. Science. 2010 Oct 8;330(6001):239-43
haspin protein, Xenopus laevis  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Xenopus Proteins. Science. 2010 Oct 8;330(6001):235-9
NDR2 protein kinase, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. J Biol Chem 2004 May 28;279(22):23806-12
NDR1 protein kinase, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Sci Signal 2010;3(126):ra47
WAG1 protein, Arabidopsis  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Arabidopsis Proteins. Development 2010 Oct;137(19):3245-55
STK32B protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Eur J Hum Genet 2010 Jun;18(6):726-32
salt-inducible kinase-2, human  EC 2.7.1.-   *Protein-Serine-Threonine Kinases. Cancer Cell. 2010 Aug 9;18(2):109-21
Smg1 protein, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Proc Natl Acad Sci U S A 2010 Jul 6;107(27):12186-91
CDKL5 protein, rat  EC 2.7.11.22   *Protein-Serine-Threonine Kinases. Neurobiol Dis. 2010 Jun;38(3):414-24
MAP4K3 protein, Drosophila  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Drosophila Proteins. Dev Biol. 2010 Aug 1;344(1):150-7
LRRK2 protein, zebrafish  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Zebrafish Proteins. PLoS Genet 2010;6(4):e1000914
Atg2 protein, Drosophila  EC 2.7.1.37   *Protein-Serine-Threonine Kinases *Drosophila Proteins. Nature. 2010 Jun 24;465(7301):1093-6
Oca2 protein, S pombe  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Schizosaccharomyces pombe Proteins. Mol Cell Biol 2010 Jul;30(13):3396-410
FAST protein, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. J Immunol 2010 May 1;184(9):5325-32
polo-like kinase 5, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Nucleic Acids Res 2010 May;38(9):2931-43
polo-like kinase 5, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Nucleic Acids Res 2010 May;38(9):2931-43
HUNK protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Proc Natl Acad Sci U S A 2010 Feb 9;107(6):2622-7
GAK protein, zebrafish  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Zebrafish Proteins. BMC Dev Biol 2010;10:7
CORYNE protein, Arabidopsis  EC 2.7.11.1   *Receptors, Cell Surface *Protein-Serine-Threonine Kinases. Plant Physiol 2010 Jan;152(1):166-76
Unc-82 protein, C elegans  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Caenorhabditis elegans Proteins. Genetics 2010 Jan;184(1):79-90
Stk40 protein, mouse  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Proc Natl Acad Sci U S A 2010 Jan 26;107(4):1402-7
Nek4 protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Cancer Res 2010 Feb 1;70(3):1033-41
LRRK2 protein, rat  EC 2.7.1.37   *Protein-Serine-Threonine Kinases Parkinson Disease. Neurosci Lett. 2010 Jan 4;468(2):120-4
ULK3 protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases. Exp Cell Res 2010 Feb 15;316(4):627-37
Stk1 protein, Staphylococcus aureus  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Virulence Factors. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Nov 1;65(Pt 11):1187-9
STRAD protein, C elegans  0   *Caenorhabditis elegans Proteins Protein-Serine-Threonine Kinases. Development 2010 Jan;137(1):93-102
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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