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DNA-Activated Protein Kinase

More information in Books or onNLM PubMed
Definition: A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR PROTEIN P53 and a variety of TRANSCRIPTION FACTORS.      Other names Protein Kinase, DNA-Dependent; Protein Kinase, DNA-Activated; Kinase, DNA-Dependent Protein; Kinase, DNA-Activated Protein; DNA Dependent Protein Serine Threonine Kinase; DNA Dependent Protein Kinase; DNA Activated Protein Kinase; DNA-Dependent Protein Serine-Threonine Kinase; DNA-Dependent Protein Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4,5-dimethoxy-2-nitrobenzaldehyde  0   *Benzaldehydes DNA-Activated Protein Kinase/antagonists & inhibitors. Mol Cancer. 2011;10() (dup#48):46
2-(4-methoxyphenyl)-6-(morpholin-4-yl)pyran-4-one  0   *Morpholines *Pyrones DNA-Activated Protein Kinase/antagonists & inhibitors. J Med Chem 2007 Apr 19;50(8):1958-72
2-N-morpholino-8-dibenzofuranylchromen-4-one  0   *Chromones *Thiophenes DNA-Activated Protein Kinase/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7829-46
8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one  0   *Chromones *Morpholines DNA-Activated Protein Kinase/antagonists & inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7
Prkdc protein, mouse  EC 2.7.1.37   *DNA-Binding Proteins *Nuclear Proteins *DNA-Activated Protein Kinase.
PRKDC protein, human  EC 2.7.1.37   *Nuclear Proteins *DNA-Activated Protein Kinase.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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