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Parkinson Disease

More information in Books or onNLM PubMed
Definition: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)  drug ther: consider also ANTIPARKINSON AGENTS; /chem ind   
See Also Lewy Bodies 		Other names Primary Parkinsonism; Paralysis Agitans; Lewy Body Parkinson Disease; Idiopathic Parkinson Disease; Parkinson's Disease, Lewy Body; Parkinson's Disease, Idiopathic; Parkinson's Disease; Parkinson Disease, Idiopathic; Lewy Body Parkinson's Disease; Idiopathic Parkinson's Disease; Parkinsonism, Primary
 
SubstanceCAS Registry & nameCategoriesSource
TRIM9 protein, human  EC 6.3.2.19   *Nerve Tissue Proteins *Ubiquitin-Protein Ligases Parkinson Disease. Neurobiol Dis. 2010 May;38(2):210-8
LRRK2 protein, rat  EC 2.7.1.37   *Protein-Serine-Threonine Kinases Parkinson Disease. Neurosci Lett. 2010 Jan 4;468(2):120-4
Parkinsonism, early onset with mental retardation  0   *Basal Ganglia Diseases *Intellectual Disability *Parkinson Disease *Genetic Diseases, X-Linked.
Parkinson disease, juvenile, autosomal recessive  0   *Parkinson Disease.
Parkinson disease 3  0   *Parkinson Disease.
USP24 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Parkinson Disease. Hum Mutat 2006 Oct;27(10):1017-23
USP40 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Parkinson Disease. Hum Mutat 2006 Oct;27(10):1017-23
LRRK2 protein, human  EC 2.7.1.37   *Protein-Serine-Threonine Kinases Parkinson Disease. Neuron 2004 Nov 18;44(4):601-7
GPR37 receptor, human  0   *Receptors, G-Protein-Coupled Parkinson Disease. J Neurol. 2003 Oct;250 Suppl 3:III25-9
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone  0   *Acetophenones Catechol O-Methyltransferase/antagonists & inhibitors Parkinson Disease/drug therapy. Eur J Pharmacol 2001 May 18;420(1):27-32
parkin protein  EC 6.3.2.19   *Ubiquitin-Protein Ligases Parkinson Disease. Nature 1998 Apr 9;392(6676):605-8; Science 1998 Apr 10;280(5361):203
dopamine-releasing factor, rat  0   *Glycoproteins Parkinson Disease/therapy. Brain Res 1988;463(2):385

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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