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Pyridones

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Definition: Pyridine derivatives with one or more keto groups on the ring.     
Examples Bemegride; Iodopyridones; Mimosine; Trazodone 		Other names Pyridinones
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-pyridone-3-carboxamide-1-ribonucleoside monophosphate  0   *Nucleotides *Pyridones. J Ren Nutr. 2012 Jan;22(1):95-7.
methyl 3-(2-(3-chloro-4-fluorobenzyl)-7-hydroxy-5-isopropyl-1,3,6-trioxo-2,3,5,6-tetrahydro-1H-pyrrolo(3,4-c)pyridin-4-yl)propanoate  0   *Imides *Pyridones HIV Integrase Inhibitors. Chem Biol Drug Des. 2012 Feb;79(2):157-65.
2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one  0   *Pyridones *Pyrimidines HSP90 Heat-Shock Proteins/antagonists & inhibitors. Anticancer Res. 2012 Feb;32(2):453-62.
6-(4-chlorobutyl)-5-hydroxy-4-(phenylthio)-1-tosyl-5,6-dihydropyridine-2(1H)-one  0   *Pyridones *Tosyl Compounds. Pharmacology. 2011;88(1-2):26-32.
2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one  0   *Pyridones *Pyrimidines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Mol Cancer Ther. 2011 Nov;10(11):2189-99.
3-tert-butyl-1-(4-chlorophenyl)-4-(4-methoxyphenyl)indeno(1,2-b)pyrazolo(4,3-e)pyridin-5(1H)-one  0   *Pyrazoles *Pyridones. Acta Crystallogr C. 2011 Dec;67(Pt 12):o479-83
3-tert-butyl-1-(4-chlorophenyl)-4-phenylindeno(1,2-b)pyrazolo(4,3-e)pyridin-5(1H)-one  0   *Pyrazoles *Pyridones. Acta Crystallogr C. 2011 Dec;67(Pt 12):o479-83
5-ethyl-1-phenyl-2-(1H) pyridone  0   *Pyridones. Res Commun Mol Pathol Pharmacol. 2009-2010;122-123(1-6):27-50
N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide  0   *Pyridones *Sulfones Leukocyte Elastase/antagonists & inhibitors. J Pharmacol Exp Ther. 2011 Oct;339(1):313-20.
torrubiellone C  0   *Pyridones Alkaloids. Org Lett. 2011 Aug 19;13(16):4368-70
3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta(b)pyridin-7-one  0   *Pyridones. Arch Pharm Res. 2011 Jun;34(6):907-12
1-(2-hydroxyethoxy)methyl-2-methyl-3-hydroxyl-4-pyridinone  0   *Pyridones. Hemoglobin. 2011;35(3):291-300
GSK 1120212  0   *Pyridones *Pyrimidinones MAP Kinase Kinase 1/antagonists & inhibitors MAP Kinase Kinase 2/antagonists & inhibitors. JOP 2011;12(2):114-6
6-(3-hydroxy-4-oxo-2-methyl-4(1H)-pyridin-1-yl)norleucine  0   *Pyridones Norleucine/*analogs & derivatives. Eur J Pharm Biopharm 2011 May;78(1):75-82
TAK 733  0   *Pyridones *Pyrimidinones. Bioorg Med Chem Lett 2011 Mar 1;21(5):1315-9
6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido(2,3-d)pyrimidin-7(8H)-one  0   *Pyridones *Pyrimidines Mitogen-Activated Protein Kinase 14/antagonists & inhibitors. J Med Chem 2011 Apr 14;54(7):2433-46
5-(ethoxycarbonyl)-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one  0   *Pyridones. Colloids Surf B Biointerfaces. 2011 May 1;84(1):272-9
4-((4-fluorobenzyl)oxy)-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyridin-2(1H)-one  0   *Pyridones Receptors, Somatostatin/antagonists & inhibitors. Bioorg Med Chem. 2011 Jan 15;19(2):883-93
pyrano(3',4'-4,5)imidazo(1,2-a)pyridin-1-one  0   *Imidazoles *Pyridones. Org Biomol Chem. 2011 Feb 21;9(4):1212-8
5-(4-fluorophenyl)-2-hydroxypyridine  0   *Pyridones. J Photochem Photobiol B 2010 Dec 2;101(3):304-12
torrubiellone A  0   *Alkaloids *Pyridones. J Nat Prod. 2010 Dec 27;73(12);2057-60
4-pyridone-3-carboxamide-1-ribonucleoside  0   *Nucleosides *Pyridones. J Ren Nutr 2010 Sep;20(5 Suppl):S7-10
2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo(4,3-c)pyridine-3,6(2H,5H)-dione  0   *Pyrazoles *Pyridones NADPH Oxidase/antagonists & inhibitors. Am J Physiol Renal Physiol 2010 Dec;299(6):F1348-58
1,2-HOPO-2 cpd  0   *Pyridones. Angew Chem Int Ed Engl. 2010 Sep 10;49(38):6795-7
5-methyl-1-(4-hydroxylphenyl)-2-(1H)-pyridone  0   *Phenols *Pyridones. J Chromatogr B Analyt Technol Biomed Life Sci 2010 Sep 15;878(26):2442-8
PD 173956  0   *Pyridones *Pyrimidines src-Family Kinases/antagonists & inhibitors. Br J Pharmacol 2010 Jun;160(4):958-70
6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo(4,5-c)pyridin-4(5H)-one  0   *Pyridones Receptors, Metabotropic Glutamate/antagonists & inhibitors. Eur J Pharmacol 2010 Aug 10;639(1-3):106-14
N-cyclopropyl-3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido(3,2-d)pyridazin-3-yl)-4-methylbenzamide  0   *Pyridazines *Pyridones p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2010 Sep 9;53(17):6398-411
1,4-dimethyl-2-pyridinone  0   *Pyridones. J Phys Chem A. 2010 Jul 15;114(27):7377-81
perampanel  0   *Pyridones Receptors, AMPA/antagonists & inhibitors. Mov Disord 2010 May 15;25(7):896-905
lycoposerramine R  0   *Pyridones. Org Lett. 2010 Jun 4;12(11):2551-3
PF 68742  0   *Pyridones *Sulfonamides. J Virol 2010 Jul;84(14):7288-99
BMS 577098  0   *Benzimidazoles *Pyridones. Bioorg Med Chem Lett 2010 May 15;20(10):3182-5
imidazo(4,5-b)pyridin-7-one  0   *Imidazoles *Pyridones. Eur J Med Chem. 2010 Jun;45(6):2480-8
2-(hexahydrocyclopenta(c)pyrrol-2-ylamino)-8-methyl-6-o-tolyl-8H-pyrido(2,3-d)pyrimidine-7-one  0   *Pyridones *Pyrimidines. Int Immunopharmacol 2010 Apr;10(4):467-73
N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide  0   *Aminopyridines *Pyridones. J Med Chem 2009 Mar 12;52(5):1251-4
3-isobutyl-tetrahydro-imidazo(1,2-a)pyridine-2,5-dione  0   *Pyridones. J Asian Nat Prod Res. 2010 Apr;12(4):331-3
4-(benzyloxy)-1-(4-(2-pyrrolidin-1-ylethoxy)phenyl)pyridin-2(3H)-one  0   *Pyridones *Pyrrolidines. Br J Pharmacol 2010 Jan 1;159(2):374-83
1-hydroxy-2(1H)-pyridinone  0   *Pyridones. Inorg Chem 2009 Nov 16;48(22):769-79
bis(3-hydroxy-n-methylpyridin-2-one)  0   *Pyridones. Inorg Chem. 2009 Dec 21;48(24):11489-91
2-(4-iodophenylamino)pyrido(2,3-d)pyrimidin-7-one  0   *Pyridones *Pyrimidines Iodine Radioisotopes. Nucl Med Biol 2005 May;32(4):313-21
1,2,3,4-tetrahydro-2,2-dimethyl-6-(trifluoromethyl)-8-pyridono(5,6-g)quinoline  0   *Pyridones *Quinolines. Photochem Photobiol. 2009 Sep-Oct;85(5):1225-32
6-chloro-5-hydroxy-2-pyridone  0   *Pyridones. Acta Crystallogr C. 2009 Oct;65(Pt 10):o529-33
1-(difluoromethyl)-5-((4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2(1H)-one  0   *Pyridones. Bioorg Med Chem. 2009 Aug 15;17(16):6106-22
4-acetyl-1,3-dihydroimidazo(4,5-c)pyridin-2-one  0   *Imidazoles *Pyridones. Nt Prod Commun. 2009 Jul;4(7):971-6
bolaamphiphile  0   *Furans *Pyridones. Chem Commun (Camb). 2008 Nov 30;(44):5770-2
2-(3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl)-N-(3'',4''-dichlorobenzyl)acetamide  0   *Pyridones Glycogen Phosphorylase/antagonists & inhibitors. Bioorg Med Chem 2009 Jul 1;17(13):4724-33
homoclausenamide  0   *Pyridones. Org Biomol Chem 2009 Jun 21;7(12):2628-34
PH 797804  0   *Benzamides *Pyridones p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. Biochemistry 2009 Jul 14;48(27):6402-11
2-(N-difluoromethyl-1,2-dihydropyridin-2-one)  0   *Pyridones. Bioorg Med Chem Lett. 2009 Feb 1;19(3):584-8
nygerone A  0   *Benzyl Compounds *Pyridones. Org Biomol Chem. 2009 Feb 7;7(3):435-8
1,3,5-tris(4-(3-hydroxy-2-methyl-4-oxo-4H-pyridin-1-yl)butylcarbamoyl)-1,3,5-trimethylcyclohexane  0   *Cyclohexanes *Pyridones. J Inorg Biochem 2009 Feb;103(2):262-73
1,3,5-tris(3-(3-hydroxy-2-methyl-4-oxo-4H-pyridin-1-yl)propylcarbamoyl)-1,3,5-trimethylcyclohexane  0   *Cyclohexanes *Pyridones. J Inorg Biochem 2009 Feb;103(2):262-73
PSN 375963  0   *Oxadiazoles *Pyridones. Br J Pharmacol 2008 Dec;155(7):1056-65
4-pyridone  0   *Pyridones. Acta Crystallogr C 2008 Dec;64(Pt 12):o661-4
pamapimod  0   *Pyridones *Pyrimidines p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2008 Dec;327(3):610-9
N,N'-bis(guanidinoethyl)-2,6-pyridinedicarboxamide  0   *Pyridones Guanidine/*analogs & derivatives. Bioconjug Chem. 2008 Sep;19(9):1840-8
4-oxo-4,7-dihydrofuro(2,3-b)pyridine-5-carboxamide  0   *Furans *Pyridones. Bioorg Med Chem Lett 2008 Jul 15;18(14):3856-9
1-(pyridin-2-yl)-enone  0   *Pyridones. J Org Chem. 2008 Sep 19;73(18):7088-95
4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo(d)imidazol-2-yl)pyridin-2(1H)-one  0   *Benzimidazoles *Pyridones. J Med Chem 2008 Oct 9;51(19):5897-900
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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