encyclopedia of medical concepts
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Leukocyte Elastase
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Definition
: An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
Other names
Leukocyte Elastase, Polymorphonuclear; Elastase, Polymorphonuclear Leukocyte; Elastase, PMN; Elastase, Neutrophil; Elastase, Lysosomal; Elastase, Leukocyte; Elastase, Granulocyte; Granulocyte Elastase; Polymorphonuclear Leukocyte Elastase; PMN Elastase; Neutrophil Elastase; Lysosomal Elastase
Substance
CAS Registry & name
Categories
Source
Drugs
*
KRP-
109
0
*Pyrrolidines
*Benzoxazines
Leukocyte Elastase/antagonists & inhibitors.
Pulm Pharmacol Ther. 2011 Dec;24(6):660-5.
cereoaldomine
0
*Polyketides
Leukocyte Elastase/antagonists & inhibitors.
J Nat Prod. 2011 Oct 28;74(10):2282-5
trypethelone
0
*Polyketides
Leukocyte Elastase/antagonists & inhibitors.
J Nat Prod. 2011 Oct 28;74(10):2282-5
cereolactam
0
*Polyketides
Leukocyte Elastase/antagonists & inhibitors.
J Nat Prod. 2011 Oct 28;74(10):2282-5
pterolinus L
0
*Chalcones
Leukocyte Elastase/antagonists & inhibitors.
Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5630-2.
pterolinus K
0
*Phenanthrenes
Leukocyte Elastase/antagonists & inhibitors.
Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5630-2.
N-
((5-
(methanesulfonyl)pyridin-
2-
yl)methyl)-
6-
methyl-
5-
(1-
methyl-
1H-
pyrazol-
5-
yl)-
2-
oxo-
1-
(3-
(trifluoromethyl)phenyl)-
1,2-
dihydropyridine-
3-
carboxamide
0
*Pyridones
*Sulfones
Leukocyte Elastase/antagonists & inhibitors.
J Pharmacol Exp Ther. 2011 Oct;339(1):313-20.
6-
O-
p-
methoxycinnamoyl scandoside methyl ester
0
*Iridoids
Leukocyte Elastase/antagonists & inhibitors.
Bioorg Med Chem Lett 2010 Jan 15;20(2):512-5
isodeoxyhelicobasidin
0
*Cyclopentanes
*Benzoquinones
Leukocyte Elastase/antagonists & inhibitors.
J Antibiot (Tokyo) 2009 Jun;62(6):333-4
Iris protein, Ixodes ricinus
0
*Serpins
Leukocyte Elastase/antagonists & inhibitors.
J Biol Chem 2006 Sep 8;281(36):26361-9
depelestat
0
*Peptides
Leukocyte Elastase/antagonists & inhibitors.
J Pharmacol Exp Ther 2006 Aug;318(2):803-9
ONO 6818
0
*Oxadiazoles
Pyrimidinones
Leukocyte Elastase/antagonists & inhibitors.
J Med Chem 2000 Dec 28;43(26):4927-9
SYN 1390
0
*Cephalosporins
Leukocyte Elastase/antagonists & inhibitors.
Steroids 2000 Apr;65(4):697-703
SYN 1396
0
*Cephalosporins
Leukocyte Elastase/antagonists & inhibitors.
Steroids 2000 Apr;65(4):697-703
2-
(6'-
methoxy-
3',4'-
dihydro-
1'-
naphthyl)-
4H-
3,1-
benzoxazin-
4-
one
0
*Benzoxazines
Leukocyte Elastase.
Bioorg Med Chem Lett 1999 May 3;9(9):1291-4
FR 901277
0
*Amides
Leukocyte Elastase.
Inflamm Res 1999 Mar;48(3):160-7
GW 311616
0
*Piperidines
Leukocyte Elastase/antagonists & inhibitors.
Rapid Commun Mass Spectrom 1999;13(5):456-63
2-
(3-
methylsulfonylamino-
2-
oxo-
6-
phenyl-
1,2-
dihydro-
1-
pyridyl)-
N-
(3,3,3-
trifluoro-
1-
isopropyl-
2-
oxopropyl)acetamide
0
*Pyridones
*Sulfonamides
Leukocyte Elastase/antagonists & inhibitors.
Naunyn Schmiedebergs Arch Pharmacol 1998 Aug;358(2):253-63
NX 21909
0
*Oligonucleotides
Valine/*analogs & derivatives
Leukocyte Elastase/antagonists & inhibitors.
Curr Biol 1997 Nov 1;7(11):877-80
FK 706
0
*Benzoates
*Pyrrolidines
Pancreatic Elastase/antagonists & inhibitors
Leukocyte Elastase/antagonists & inhibitors.
Eur J Pharmacol 1997 Oct 15;337(1):63-71
ZD 8321
0
*Oligopeptides
Leukocyte Elastase/antagonists & inhibitors.
J Med Chem 1997 Sep 26;40(20):3173-81
4-
((((4-
chloro-
3-
(((((4-
hydroxy-
3,5-
di-
tert-
butylphenyl)thio)acetyl)amino)sulfonyl)phenyl)carbonyl)amino)sulfonyl)benzoyl-
valyl-
(perhydroindole-
2-
carbonyl)-
valine trifluoromethyl ketone
0
*Oligopeptides
Leukocyte Elastase/antagonists & inhibitors.
J Med Chem 1997 Jun 6;40(12):1906-18
((4-
methoxyphenyl)carbonyl)-
valyl-
N-
(3-
(1,1,1-
trifluoro-
2-
hydroxy-
4-
methylpentyl))prolinamide
105080-60-2
*Dipeptides
Leukocyte Elastase/antagonists & inhibitors.
J Med Chem 1997 Jun 6;40(12):1876-85
4-
chloro-
7-
(iodoacetyl)amino-
3-
methoxyisocoumarin
0
*Coumarins
Leukocyte Elastase/antagonists & inhibitors.
Acta Crystallogr C 1996 Feb 15;52 Pt 2:451-3
ONO 5046
127373-66-4 Glycine, N-
(2-
(((4-
(2,2-
dimethyl-
1-
oxopropoxy)phenyl)sulfonyl)amino)benzoyl)
*Sulfonamides
Glycine/*analogs & derivatives
Stereoisomerism
Leukocyte Elastase/antagonists & inhibitors.
Pharma Action
Serine Proteinase Inhibitors
Biochem Biophys Res Commun 1991;177(2):814
flurithromycin
82664-20-8
Erythromycin/analogs & derivatives
Leukocyte Elastase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
Chemioterapia 1985;4(2):156
alpha 1-
antitrypsin-
leukocyte elastase complex
0
*alpha 1-Antitrypsin
*Leukocyte Elastase.
Blood 1983;61(5):842