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Serpins

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Definition: A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.  "a family of SERine Proteinase INhibitors", thus the source of the name   
Pharmacological Action Serine Proteinase Inhibitors
Examples Angiotensinogen; alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; alpha-2-Antiplasmin; Antithrombin Proteins; Complement C1 Inactivator Proteins; Plasminogen Inactivators 		Other names Serpin Superfamily; Superfamily, Serpin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SERPINA13 protein, human  0   *Serpins. Neurosci Lett. 2011 Oct 17;504(1):32-4
serine protease inhibitor Kazal-type 2, mouse  0   *Serpins. J Biol Chem 2011 Aug 19;286(33):29108-17
Spn1 protein, Drosophila  0   *Serpins *Drosophila Proteins. Mol Cell Biol 2011 Jul;31(14):2960-72
Serpin1 protein, Arabidopsis  0   *Serpins *Arabidopsis Proteins. J Biol Chem 2010 Apr 30;285(18):13550-60
SERPINA11 protein, human  0   *Serpins.
Spn5 protein, Drosophila  0   *Serpins *Drosophila Proteins. Int J Dev Biol 2008;52(7):933-42
serpin-28D protein, Drosophila  0   *Serpins *Drosophila Proteins. Dev Biol 2008 Nov 15;323(2):189-96
Serpinb13 protein, mouse  0   *Serpins.
SERPINB13 protein, human  0   *Serpins.
Serpinb6e protein, mouse  0   *Serpins.
Serpinb6d protein, mouse  0   *Serpins.
Serpinb6c protein, mouse  0   *Serpins.
Serpinb6b protein, mouse  0   *Serpins.
serpin 6 protein, C elegans  0   *Serpins *Caenorhabditis elegans Proteins. Cell 2007 Sep 21;130(6):1108-19
SERPINB11 protein, human  0   *Serpins. J Biol Chem 2007 Aug 24;282(34):24948-60
SERPINB11 protein, mouse  0   *Serpins. J Biol Chem 2007 Aug 24;282(34):24948-60
Serpinb1a protein, mouse  0   *Serpins. J Exp Med 2007 Aug 6;204(8):1901-9
BLI-5 protein, C elegans  0   *Serpins *Caenorhabditis elegans Proteins. Int J Parasitol 2006 May 31;36(6):681-9
Serpina3n protein, mouse  0   *Acute-Phase Proteins *Serpins. J Immunol 2006 Oct 15;177(8):5051-8
SERPINA3 protein, human  0   *Serpins Biological Markers. Hypertension 2007 Jan;49(1):76-83
Iris protein, Ixodes ricinus  0   *Serpins Leukocyte Elastase/antagonists & inhibitors. J Biol Chem 2006 Sep 8;281(36):26361-9
SRP-3 protein, C elegans  0   *Serpins *Caenorhabditis elegans Proteins Muscle Proteins. Biochemistry 2006 Apr 11;45(14):4474-80
Serpini2 protein, mouse  0   *Serpins. PLoS Genet 2005 Sep;1(3):e38
Mcr protein, Drosophila  0   *Serpins *Cytokines. PLoS Biol 2006 Jan;4(1):e4
SERPINA12 protein, human  0   *Serpins. Biochem Biophys Res Commun 2006 Jan 6;339(1):430-6
vaspin protein, rat  0   *Serpins. Proc Natl Acad Sci U S A 2005 Jul 26;102(30):10610-5
SPI-CI protein, mouse  0   *Serpins. Blood 2005 Feb 1;105(3):1153-61
Spink5 protein, mouse  0   *Serpins. Nat Genet 2005 Jan;37(1):56-65
Serpinb3b protein, mouse  0   *Serpins. Biochem Biophys Res Commun 2004 Nov 26;324(4):1340-5
Serpinb7 protein, mouse  0   *Serpins.
Serpinb7 protein, rat  0   *Serpins.
Serpina3k protein, mouse  0   *Serpins.
Spn4 protein, Drosophila  0   *Serpins *Drosophila Proteins. FEBS Lett 2000 Feb 25;468(2-3):194-8
Serpina10 protein, mouse  0   *Serpins.
SRP-2 protein, C elegans  0   *Serpins *Caenorhabditis elegans Proteins. J Biol Chem 2004 Apr 9;279(15):15448-59
SERPINA9 protein, human  0   *Neoplasm Proteins *Serpins. Am J Pathol. 2003 Jul;163(1);135-44
HongrES1 protein, rat  0   *Serpins. Cell Res 2002 Dec;12(5-6):407-10
Spn27A protein, Drosophila  0   *Serpins *Drosophila Proteins. Dev Cell 2002 Oct;3(4):581-92
trespin protein, rat  0   *Serpins. J Biol Chem 2002 Jul 19;277(29):26412-21
SERPINB12 protein, human  0   *Serpins. J Biol Chem 2001 Dec 28;276(52):49320-30
serpin-2  0   *Serpins. Insect Biochem Mol Biol 2001 Jul 26;31(9):887-98
nec protein, Drosophila  0   *Serpins *Drosophila Proteins. Genetics 2000 Nov;156(3):1117-27
phloem serpin 1  0   *Serpins. J Biol Chem 2000 Nov 10;275(45):35122-8
SERPINA10 protein, human  0   *Serpins. Biochemistry 1999 Aug 24;38(34):11073-8
endopin 2  0   *Serpins. Biochemistry 2000 Aug 1;39(30):8944-52
SERPINBP1 pseudogene, human  0   *Serpins. Genomics 1999 Dec 15;62(3):490-9
Serpina3n protein, rat  0   *Acute-Phase Proteins *Serpins. Cytokine 1999 Nov;11(11):856-62
SERPINA3 protein, Bos taurus  0   *Serpins. J Biol Chem 1999 Nov 26;274(48):34164-73
EP45 protein, Xenopus  0   *Serpins *Xenopus Proteins. J Biol Chem 1999 Sep 17;274(38):26843-9
Bm-SPN-2 protein, Brugia malayi  0   *Helminth Proteins *Serpins. Blood 1999 Aug 15;94(4):1418-2
SERPINI2 protein, human  0   *Neoplasm Proteins *Serpins. Genes Chromosome Cancer 1998 Jul; 22(3):179-85; Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3700-5
raPit5a protein, rat  0   *Serpins. FEBS Lett 1998 Dec 4;440(3):361-4
SERPINB7 protein, human  0   *Serpins. J Clin Invest 1998 Aug 15;102(4):828-36
Caspin  0   *Serpins. J Biol Chem 1998 Jun 12;273(24):15125-30
SERPINB8 protein, human  0   *Serpins. J Biol Chem 1995 Dec 15;270(50):29854-61
Serpinb9 protein, mouse  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases *Serpins. J Biol Chem 1997 Jun 13;272(24):15434-41; J Gen Physiol 2002 Aug;120(2):191-201
SERPINB9 protein, human  0   *Serpins. J Biol Chem 1996 Nov 1;271(44):27802-9
BSZx protein, Hordeum vulgare  0   *Plant Proteins *Serpins. Plant Mol Biol 1996 Feb;30(3):673-783-8
PAZ1 protein, Hordeum vulgare  0   *Plant Proteins *Serpins. Plant Mol biol 1996 Feb 30(3):673-7
LICI-3 protein, Tachypleus tridentatus  0   *Serpins *Arthropod Proteins. J Biol Chem 1996 Sep 27;271(39):23768-74
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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