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Acute-Phase Proteins

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Definition: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.  blood proteins; /biosyn /drug eff /physiol permitted   
Examples alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; alpha-Macroglobulins; C-Reactive Protein; Ceruloplasmin; Complement C3; Fibrinogen; Haptoglobins; Hemopexin; Orosomucoid; Serum Albumin; Serum Amyloid A Protein; Serum Amyloid P-Component; Transferrin; Trypsin Inhibitor, Kazal Pancreatic 		Other names Reactants, Acute-Phase; Proteins, Acute-Phase; Acute-Phase Reactants; Reactants, Acute Phase; Proteins, Acute Phase; Protein, Acute-Phase; Glycoproteins, Acute-Phase; Acute Phase Reactants; Acute Phase Proteins; Acute Phase Protein; Acute Phase Glycoproteins; Acute-Phase Protein; Acute-Phase Glycoproteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Serpina3n protein, mouse  0   *Acute-Phase Proteins *Serpins. J Immunol 2006 Oct 15;177(8):5051-8
neutrophil gelatinase-associated lipocalin protein, rat  0   *Acute-Phase Proteins *Proto-Oncogene Proteins *Lipocalins. Am J Pathol 2006 Dec;169(6):2245-53
LCN2 protein, human  0   *Acute-Phase Proteins *Proto-Oncogene Proteins *Lipocalins.
mucosal pentraxin protein, rat  0   *Acute-Phase Proteins. FASEB J 2003 Jul;17(10):1277-85
Serpina3n protein, rat  0   *Acute-Phase Proteins *Serpins. Cytokine 1999 Nov;11(11):856-62
IHRP protein, pig  0   *Acute-Phase Proteins *Glycoproteins. J Biochem (Tokyo) 1996 Mar;119(3):577-84
MAP protein, Sus scrofa  0   *Acute-Phase Proteins. FEBS Lett 1995 Sep 11;371(3):227-30
PTX3 protein  148591-49-5   *Serum Amyloid P-Component *C-Reactive Protein Acute-Phase Proteins. J Biol Chem 1992 Nov 5;267(31):22190-7
Lcn2 protein, mouse  126469-30-5   *Acute-Phase Proteins *Oncogene Proteins *Lipocalins. Biochem Biophys Res Commun 1991;180(1):69
mannose binding protein A  143107-68-0   *Mannose-Binding Lectin Acute-Phase Proteins Mannose. J Immunol 1991;147(2):692
lipopolysaccharide-binding protein  0   *Acute-Phase Proteins *Carrier Proteins *Membrane Glycoproteins Lipopolysaccharides. J Exp Med 1989;170(4):1231
rheumatoid arthritis specific protein, human  0   *Acute-Phase Proteins. Nippon Seikeigeka Gakkai Zasshi 1985;59(11):907
acute-phase phosphoprotein pp63  0   *Acute-Phase Proteins *Phosphoproteins Glycoproteins. Biochem J 1985;230(3):603
alpha 1-inhibitor 3  0   *Acute-Phase Proteins Macroglobulins.
Pharma Action Protease Inhibitors 		Biochim Biophys Acta 526(1):218;1978
histidine-rich proteins  0 HRG  *Proteins Acute-Phase Proteins Anti-Bacterial Agents Antifungal Agents Blood Proteins. Proc Soc Exp Biol Med 158(4):647;1978
acute-phase protein rho  0   *Acute-Phase Proteins Antigens. Am J Obset Gynecol 122(8):955;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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