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Fibrinogen

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Definition: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.  a blood coag factor: do not confuse X ref FACTOR I with COMPLEMENT FACTOR I   
See Also Coagulants; Hemostatics
Examples Fibrinogens, Abnormal 		Other names Factor I; Coagulation Factor I; gamma Fibrinogen; I, Coagulation Factor; Factor I, Coagulation; gamma-Fibrinogen; Blood Coagulation Factor IDrugs* : IBRIN; RADIONUCLIDE-LABELED (125 I) FIBRINOGEN (HUMAN) SENSOR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
polyhemoglobin-fibrinogen  0   *Hemoglobins Fibrinogen/*analogs & derivatives Blood Substitutes. Artif Cells Blood Substit Immobil Biotechnol 2007;35(5):481-9
fibrinogen gamma 399 truncated  0   *Fibrinogen *Peptide Fragments. Cancer Res 2006 Oct 1;66(19):9691-7
fibrinogen gamma (151-411)  0   *Fibrinogen *Peptide Fragments. Cancer Res 2006 Oct 1;66(19):9691-7
TachoSil  0   *Thrombin *Fibrinogen Drug Combinations Surgical Sponges. J Chir (Paris). 2007 Jan-Feb;144(1):82-3
alphastatin  0   *Fibrinogen. World J Gastroenterol. 2006 Jul 14;12(26):4130-6
Fgl2 protein, mouse  0   *Fibrinogen T-Lymphocytes.
FbsB protein, Streptococcus agalactiae  0   *Carrier Proteins *Fibrinogen. Infect Immun. 2004 Jun;72(6):3495-504
Fgl1 protein, mouse  0   *Fibrinogen. Cell Res 2002 Dec;12(5-6);353-61
fibrinogen Aalpha  0   *Fibrinogen. Thromb Haemost 2002 Feb;87(2):354-5
P2-C protein, fibrinogen  0   *Fibrinogen *Peptide Fragments. J Biol Chem 2001 Apr 27;276(17):13995-4003
desA-profibrin  0   *Fibrinogen *Peptide Fragments. Blood 2000 Oct 15;96(8):2793-802
BBeta fibrinogen  0   *Fibrinogen. Blood 1998 Nov 1;92(9):3286-93
urokinase-fibrinogen conjugate  0   *Urokinase-Type Plasminogen Activator Fibrinogen/*analogs & derivatives. Bioorg Khim 1998 May;24(5):376-8
G17psi peptide  0   *Fibrinogen *Peptide Fragments. Biochemistry 1996 Oct 8;35(40):13030-9
fibrinogen Aalpha (529-39)  0   *Fibrinogen *Peptide Fragments Epitopes. Blood Coagul Fibrinolysis 1996 Jan;7(1):85-92
fibrinogen alphaC  0   *Fibrinogen *Peptide Fragments. J Biol Chem 1996 Feb 2;271(5):2523-30
FGL2 protein, human  0   *Fibrinogen T-Lymphocytes. Gene 1995 Jul 28;160(2):257-62
tachocomb  0   *Fibrinogen *Aprotinin *Thrombin Drug Combinations Hemostasis, Surgical. J Cardiovasc Surg (Torino) 1994 Dec;35(6 Suppl 1):169-70
fibrinogen Aalpha (148-160)  0   *Fibrinogen *Peptide Fragments. Blood Coagul Fibrinolysis 1990 Oct;1(4-5):521
fibrinogen Aalpha (1-50)  0   *Fibrinogen *Peptide Fragments. Blood Coagul Fibrinolysis 1990 Oct;1(4-5):461-3
bio-adhesio-chemo protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Factor XIII Fibrinogen Thrombin. Am J Clin Oncol 1989;12(2):156
gallium(67)-deferoxamine-dialdehyde starch-fibrinogen conjugate  0   *Deferoxamine *Fibrinogen Starch/*analogs & derivatives Gallium Radioisotopes. Eur J Nucl Med 1988;14(2):60
FTCH hemostatic  0   *Collagen *Fibrinogen *Aprotinin *Thrombin Drug Combinations. Ann Surg 1987;205(4):432
aglycofibrinogen  0   Fibrinogen/*analogs & derivatives. Biochim Biophys Acta 1986;883(3):552
fibrinogen-methotrexate conjugate  0   Fibrinogen/*analogs & derivatives Methotrexate/*analogs & derivatives Immunotoxins. Neoplasma 1986;33(4):401
arginyl-glycyl-aspartyl-serine  91037-65-9   *Oligopeptides Fibrinogen Fibronectins.
Pharma Action Platelet Aggregation Inhibitors 		J Biol Chem 1985;260(22):11891
glycosylated fibrinogen  0   Fibrinogen/*analogs & derivatives Glycosylation. Biochemistry 1984;23(24):5888
technetium Tc 99m fibrinogen  0   *Fibrinogen *Organotechnetium Compounds. Rhinsho Hoshasen 1982;27(6):683
asialofibrinogen  0   *Asialoglycoproteins *Fibrinogen. Biochim Biophys Acta 1981;677(3-4):381
fibrinopeptides gamma  0   *Fibrinogen.
Pharma Action Platelet Aggregation Inhibitors 		Biochem Biophys Res Commun 1980;96(3):1032
cryoprecipitate coagulum  0   *Factor VIII *Fibrinogen Fibronectins. J Urol 1980;123(5):621
fibrinogen synthesis stimulator  0   *Fibrinogen. Thromb Res 15(5/6):651;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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