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Deferoxamine

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Definition: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.     
Pharmacological Action Siderophores 		Other names Desferrioxamine; Methanesulfonate, Deferoxamine; Mesylate, Desferrioxamine B; Mesylate, Deferoxamine; Mesilate, Deferoxamine; B, Desferrioxamine; B, Deferoxamine; Desferroxamine; Desferrioxamine B Mesylate; Desferrioxamine B; Desferioximine; Deferrioxamine B; Deferoximine; Deferoxamine Methanesulfonate; Deferoxamine Mesylate; Deferoxamine Mesilate; Deferoxamine B; DesferalDrugs* : DESFERAL; DEFEROXAMINE MESYLATE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-isothiocyanatobenzyl-desferrioxamine  0   *Isothiocyanates Deferoxamine/*analogs & derivatives. Eur J Nucl Med Mol Imaging 2010 Feb;37(2):250-9
40SD02  0   *Deferoxamine *Starch. Hemoglobin 2006;30(2):329-47
DfoA protein, Erwinia amylovora  0   *Bacterial Proteins *Deferoxamine. Mol Plant Microbe Interact 1998 Aug;11(8):734-42
mangan-desferrioxamin  0   *Deferoxamine *Organometallic Compounds Manganese. J R Coll Surg Edinb 1998 Feb;43(1):26-8
deferoxamineacetyl-cysteinylbiotin  0   Biotin/*analogs & derivatives Deferoxamine/*analogs & derivatives. Drug Metab Dispos 1995 Dec;23(12):1362-7
deferoxamine-gamma-folate conjugate  0   Deferoxamine/*analogs & derivatives Folic Acid/*analogs & derivatives Gadolinium. Bioconjug Chem 1996 Jan-Feb;7(1):56-62
deferoxamine G1  0   *Deferoxamine. J Infect Dis 1995 Aug;172(2):490-6
cobalt-desferal conjugate  0   *Deferoxamine *Organometallic Compounds Cobalt. Biochim Biophys Acta 1994 Dec 15;1201(3):454-60
copper-desferal complex  0   *Deferoxamine *Organometallic Compounds Copper. Biochim Biophys Acta 1994 Apr 21;1199(3):285-92
zinc-desferrioxamine  0   *Deferoxamine *Organometallic Compounds Zinc. Invest Ophthalmol Vis Sci 1994 Mar;35(3):1212-22
desferrioxamine B-succinyl-phenylalanine(1)-octreotide  151956-24-0   Deferoxamine/*analogs & derivatives Octreotide/*analogs & derivatives Gallium Radioisotopes. Horm Metab Res Suppl 1993;27:12-7
N-hydroxydesferrioxamine B  147912-59-2   Deferoxamine/*analogs & derivatives. J Antibiot (Tokyo) 1993 Feb;46(2):294-9
N-methylanthranilic-desferrioxamine  0   *Anthranilic Acids Deferoxamine/*analogs & derivatives. J Clin Invest 1993 Jan;91(1):218-24
D-CECaT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Deferoxamine Etoposide Thiotepa Carboplatin. Am J Clin Oncol 1992 Aug;15(4):319-22
7-nitrobenz-2-oxa-1,3-diazole desferrioxamine B  137756-28-6   Deferoxamine/*analogs & derivatives 4-Chloro-7-nitrobenzofurazan/*analogs & derivatives. Mol Pharmacol 1991;40(4):584
ferric-N-(3-phenylglutaryl)desferrioxamine B  134001-02-8   *Organometallic Compounds Deferoxamine/*analogs & derivatives Ferric Compounds. Magn Reson Med 1991;17(2):509
hydroxyethyl starch-deferoxamine conjugate  0   *Deferoxamine *Hetastarch.
Pharma Action Iron Chelating Agents 		J Cardiovasc Pharmacol 1991;17(1):166
manganese desferioxamine  125892-49-1   Deferoxamine/*analogs & derivatives Organometallic Compounds Manganese. J Photochem Photobiol B 1990;7(2-4):261
polyethylene glycol ferrioxamine  0   *Polyethylene Glycols Deferoxamine/*analogs & derivatives Magnetic Resonance Imaging. Invest Radiol 1990;25(Suppl 1):S48
hydroxyethylstarch-deferoxamine  0   *Deferoxamine *Hetastarch. Proc Natl Acad Sci USA 1989;86(24):10108
dextran-deferoxamine  0   *Deferoxamine *Dextrans. Proc Natl Acad Sci USA 1989;86(24):10108
desferrioxamine-human serum albumin conjugate  0   *Deferoxamine *Serum Albumin. J Nucl Med Allied Sci 1988;32(1):38
gallium(67)-deferoxamine-dialdehyde starch-fibrinogen conjugate  0   *Deferoxamine *Fibrinogen Starch/*analogs & derivatives Gallium Radioisotopes. Eur J Nucl Med 1988;14(2):60
aluminoxamine  97633-18-6 Aluminum, (N'-(5-((4-((5-(acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)hydroxyamino)pentyl)-N-(5-aminopentyl)-N-hydroxybutanediamidato(3-))  *Deferoxamine *Organometallic Compounds Aluminum. Clin Chim Acta 1986;157(1):115
N-acetyldeferrioxamine B  0   Deferoxamine/*analogs & derivatives. Biochem Pharmacol 1985;34(8):1175
N-methyldeferrioxamine B  90846-21-2   Deferoxamine/*analogs & derivatives. Biochem Pharmacol 1985;34(8):1175
N-succinyldesferrioxamine B  84211-47-2 3,9,14,20,25,31-Hexaazapentatriacontan-35-oic acid, 3,14,25-trihydroxy-2,10,13,21,24,32-hexaoxo-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))  Deferoxamine/*analogs & derivatives. Eur J Nucl Med 1984;9(11):508
N-stearoyldesferrioxamine  73033-97-3 Butanediamide, N'-(5-((8-(acetylhydroxyamino)-1-oxooctyl)hydroxyamino)pentyl)-N-hydroxy-N-(5-((1-oxooctadecyl)amino)pentyl)  Deferoxamine/*analogs & derivatives. Health Phys 1979;37(6):729
ferrioxamine B  14836-73-8 (N-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido)pentyl)-3-((5-(N-hydroxyacetamido)pentyl) carbamoyl)propionohydroxamato(3-))iron  *Deferoxamine *Ferric Compounds.
Pharma Action Contrast Media ; Iron Chelating Agents 		Ann Rev Med 27:144;1976; Arch Microbiol 88(1):49;1972; Br J Haematol 1979;42(4):547; J Am Chem Soc 98(1):82;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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