encyclopedia of medical concepts
ψ 
ψ 
ψ 

Thiotepa

More information in Books or onNLM PubMed
Definition: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).     
Pharmacological Action Antineoplastic Agents, Alkylating; Myeloablative Agonists
Other names Triethylenethiophosphoramide; Thiophosphamide; Thio-Tepa; Thio Tepa; NSC6396; NSC 6396; AI324916; AI3 24916; Tris(1-aziridinyl)phosphine Sulfide; Tespamin; NSC-6396; Girostan; AI3-24916; TespaDrugs* : THIOTEPA; THIOPLEX
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TVTG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Deoxycytidine/analogs & derivatives Dexamethasone Thiotepa Vinblastine/analogs & derivatives Topotecan. Haematologica 2005 Dec;90(12):1701-3
MATILDE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Methotrexate Thiotepa Idarubicin. Neurology 2006 May 9;66(9):1435-8
STAMP V regimen  0   Thiotepa *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Carboplatin. Med Oncol 1998 Jul;15(2):89-95
TAVE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Thiotepa Vinblastine. Ann N Y Acad Sci 1995 Dec 29;770:305-14
TNT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitoxantrone Thiotepa Taxoids. Ann N Y Acad Sci 1995 Dec 29;770:288-304
MITT protocol  0   Mitoxantrone *Antineoplastic Combined Chemotherapy Protocols Thiotepa. Ann N Y Acad Sci 1995 Dec 29;770:288-304
thiotepa-glutathione conjugate  0   *Glutathione *Thiotepa. Cancer Res 1995 Apr 15;55(8):1701-6
T-NOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitoxantrone Prednisone Thiotepa Vincristine. Semin Oncol 1995 Feb;22(1 Suppl 1):21-4
TMJ protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitoxantrone Thiotepa Carboplatin. J Med 1994;25(3-4):241-50
MiCaT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Mitoxantrone Thiotepa. Anticancer Res 1992 Nov-Dec;12(6B):2243-4
D-CECaT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Deferoxamine Etoposide Thiotepa Carboplatin. Am J Clin Oncol 1992 Aug;15(4):319-22
TBV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Thiotepa Vinblastine. Cancer 1992 Feb 15;69(4):1052-60
CTCb regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Thiotepa Carboplatin. J Clin Oncol 1992;10(1):102
MTV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Thiotepa Vindesine Mitomycin. Ann Oncol 1991;2(5):347
TMM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Methotrexate Mitoxantrone Thiotepa. Ann Oncol 1990;1(6):443
MVT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Mitoxantrone Thiotepa. J Clin Oncol 1990;8(11):1782
VTMFAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Prednisone Doxorubicin Fluorouracil Methotrexate Thiotepa Vinblastine. Cancer 1990;66(1):119
VTMFP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Methotrexate Prednisone Thiotepa Vinblastine. Cancer 1990;66(1):119
VTMF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Methotrexate Thiotepa Vinblastine. Recent Results Cancer Res 1989;115:36
AVTMF protocol  0   Fluorouracil *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate Thiotepa Vinblastine. Ann Med Interne (Paris) 1989;140(6):350
TAVH protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Fluoxymesterone Thiotepa Vinblastine. Cancer 1989;64(7):1393
1-oxyl-2,2,6,6-tetramethyl-4-piperidyl-N,N,N',N'-bis(ethylene)phosphorodiamidothioate  51526-59-1   Thiotepa/*analogs & derivatives Spin Labels. Cancer Chemother Pharmacol 1985;15(3):185
TMF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Methotrexate Thiotepa. Cancer 1894;53(9):1836

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify.
We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy