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Thiotepa

More information in Books or onNLM PubMed
Definition: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).     
Pharmacological Action Antineoplastic Agents, Alkylating; Myeloablative Agonists 		Other names Triethylenethiophosphoramide; Thiophosphamide; Thio-Tepa; Thio Tepa; NSC6396; NSC 6396; AI324916; AI3 24916; Tris(1-aziridinyl)phosphine Sulfide; Tespamin; NSC-6396; Girostan; AI3-24916; TespaDrugs* : THIOTEPA; THIOPLEX
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TVTG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Deoxycytidine/analogs & derivatives Dexamethasone Thiotepa Vinblastine/analogs & derivatives Topotecan. Haematologica 2005 Dec;90(12):1701-3
MATILDE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Methotrexate Thiotepa Idarubicin. Neurology 2006 May 9;66(9):1435-8
STAMP V regimen  0   Thiotepa *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Carboplatin. Med Oncol 1998 Jul;15(2):89-95
TAVE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Thiotepa Vinblastine. Ann N Y Acad Sci 1995 Dec 29;770:305-14
TNT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitoxantrone Thiotepa Taxoids. Ann N Y Acad Sci 1995 Dec 29;770:288-304
MITT protocol  0   Mitoxantrone *Antineoplastic Combined Chemotherapy Protocols Thiotepa. Ann N Y Acad Sci 1995 Dec 29;770:288-304
thiotepa-glutathione conjugate  0   *Glutathione *Thiotepa. Cancer Res 1995 Apr 15;55(8):1701-6
T-NOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitoxantrone Prednisone Thiotepa Vincristine. Semin Oncol 1995 Feb;22(1 Suppl 1):21-4
TMJ protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitoxantrone Thiotepa Carboplatin. J Med 1994;25(3-4):241-50
MiCaT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Mitoxantrone Thiotepa. Anticancer Res 1992 Nov-Dec;12(6B):2243-4
D-CECaT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Deferoxamine Etoposide Thiotepa Carboplatin. Am J Clin Oncol 1992 Aug;15(4):319-22
TBV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Thiotepa Vinblastine. Cancer 1992 Feb 15;69(4):1052-60
CTCb regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Thiotepa Carboplatin. J Clin Oncol 1992;10(1):102
MTV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Thiotepa Vindesine Mitomycin. Ann Oncol 1991;2(5):347
TMM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Methotrexate Mitoxantrone Thiotepa. Ann Oncol 1990;1(6):443
MVT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Mitoxantrone Thiotepa. J Clin Oncol 1990;8(11):1782
VTMFAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Prednisone Doxorubicin Fluorouracil Methotrexate Thiotepa Vinblastine. Cancer 1990;66(1):119
VTMFP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Methotrexate Prednisone Thiotepa Vinblastine. Cancer 1990;66(1):119
VTMF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Methotrexate Thiotepa Vinblastine. Recent Results Cancer Res 1989;115:36
AVTMF protocol  0   Fluorouracil *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate Thiotepa Vinblastine. Ann Med Interne (Paris) 1989;140(6):350
TAVH protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Fluoxymesterone Thiotepa Vinblastine. Cancer 1989;64(7):1393
1-oxyl-2,2,6,6-tetramethyl-4-piperidyl-N,N,N',N'-bis(ethylene)phosphorodiamidothioate  51526-59-1   Thiotepa/*analogs & derivatives Spin Labels. Cancer Chemother Pharmacol 1985;15(3):185
TMF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Methotrexate Thiotepa. Cancer 1894;53(9):1836

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