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Manganese

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Definition: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)  Mn-55; Mn-50-54, 56-58   
Pharmacological Action Trace Elements
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,2,6,6-tetraethylpiperidine nitroxide  0   *Cyclic N-Oxides *Piperidines Manganese. Free Radic Res. 2011 Nov;45(11-12):1325-32.
manganese(II)-1-oxa-4,7-diazacyclononane  0   *Organometallic Compounds Manganese. Dalton Trans. 2011 Oct 21;40(39):10131-46
(Mn(3)CaO(4))(6+) cubane  0   *Bridged Compounds *Organometallic Compounds Calcium Manganese. Science. 2011 Aug 5;333(6043):733-6
(eta(6)-arene)Mn(CO)3  0   *Organometallic Compounds Manganese. Dalton Trans. 2011 Feb 21;40(7):1567-75
(eta(5)-cyclohexadienyl)Mn(CO)3  0   *Organometallic Compounds Manganese. Dalton Trans. 2011 Feb 21;40(7):1567-75
hexakis(prop-2-enamide)manganese(II) bis(perchlorate)  0   *Organometallic Compounds Manganese. Acta Crystallogr C. 2010 Nov;66(Pt 11):m358-62
Mn-(DPA-C(2))(2)-TPPS(3)  0   *Metalloporphyrins Manganese. Chem Biol. 2010 Jun 25;17(6):665-73
bis(mu3-1,8-bis(triisopropylsilylamido)naphthalene)bis(tetrahydrofuran)di-mu3-oxidodimanganese(III)  0   *Organosilicon Compounds *Coordination Complexes Manganese. Acta Crystallogr C 2010 Aug;66(Pt 8):m204-6
manganese(II) 4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diacetate  0   *Organometallic Compounds Manganese. Free Radic Biol Med 2010 Jun 1;48(11):1525-34
((H2O)(terpy)Mn(mu-O)2Mn(terpy)(OH2))(NO3)3  0   *Organometallic Compounds Manganese. Dalton Trans. 2010 Apr 28;39(16):3985-9
poly((aqua(2,2'-bipyridine-2N,N')manganese(II))-mu-croconato-(4)O,O'-O'',O''')  0   *Organometallic Compounds *Polymers Manganese. Acta Crystallogr C 2010 Apr;66(Pt 4):m97-100
poly((bis(acetonitrile-kappaN)manganese(II))-bis(mu-trifluoromethanesulfonato-kappa2O,O'))  0   *Organometallic Compounds Manganese. Acta Crystallogr C. 2010 Jan;66(Pt 1):m9-12
Mn(III) tetrakis(N,N'-diethylimidazolium-2-yl)porphyrin  0   *Metalloporphyrins Manganese. Free Radic Biol Med. 2009 Oct 1;47(7):917-23
tricarbonyl(eta(5)-1-iodocyclopentadienyl)manganese  0   *Organometallic Compounds Manganese. Acta Crystallogr C. 2009 Nov;65(Pt 11):m431-5
diaquadichloridobis(1H-imidazole)manganese(II)  0   *Organometallic Compounds Manganese. Acta Crystallogr C. 2009 Jun;65(Pt 6):m215-8
Mn-salen  0   *Organometallic Compounds Manganese. Chemistry. 2009 Jul 27;15(30):7481-9
cymantrene keto carboxylic acid  0   *Organometallic Compounds Manganese. J Inorg Biochem 2008 Dec;102(12):2114-9
Na(8)H(2)L(H(2)enMe)(4)(Mn(H(2)O)(2)((W(4)Mn(4)O(12))(P(2)W(14)O(54))(2))).17H(2)O,  0   *Organometallic Compounds Manganese Sodium Tungsten. Dalton Trans 2009 Mar 14;(10):1786-91
manganese silicide  0   *Manganese *Silicon Compounds. J Am Chem Soc. 2008 Nov 26;130(47):16086-94
tetracarboxy manganese(II) phthalocyanine  0   *Indoles *Organometallic Compounds Manganese. Spectrochim Acta A Mol Biomol Spectrosc 2008 Dec 15;71(4):1246-9
Mn(3+)-octabromotetrakis(1-methyl-pyridinium-4yl)porphine  0   *Metalloporphyrins Manganese. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1364-6
(2-(2-pyridyl)-1H-benzimidazole-kappa2N2,N3)bis(p-toluato-kappa2O,O')manganese(II)  0   *Organometallic Compounds Manganese. Acta Crystallogr C 2007 Dec;63(Pt 12):m618-21
(dipicolinato-kappa(3)O,N,O')(1H-imidazole-kappaN(3))(1,10-phenanthroline-N,N')manganese(II)  0   *Organometallic Compounds Manganese. Acta Crystallogr C. 2007 Oct;63(Pt 10):m469-72
Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin  0   *Metalloporphyrins Manganese. Free Radic Biol Med 2007 May 15;42(10):1571-8
manganese(III) acetate dihydrate  0   *Acetates *Organometallic Compounds Manganese. J Nanosci Nanotechnol 2007 Apr-May;7(4-5):1162-75
manganese 5,10,15,20-tetra (N-methyl4-pyridyl) porphinato (2-) tetraiodide salt  0   *Metalloporphyrins Manganese. Zhonghua Nan Ke Xue 2005 Feb;11(2):124-6,129
bis(kojic acid)manganese(II)  0   *Organometallic Compounds Manganese. Bioorg Med Chem Lett 2007 Jan 1;17(1):45-8
manganese(V)-oxo corrolazine  0   *Metalloporphyrins Manganese. Inorg Chem. 2006 Jun 26;45(13):5119-25
diaquabis(5-(pyrazin-2-yl-kappaN(1))-1H-tetrazolato-kappaN(1))manganese(II)  0   *Organometallic Compounds Manganese. Acta Crystallogr C 2006 Dec;62(Pt 12):m614-6
nitrosyl(N,N'-bis(2-pyridylmethyl)amine-N-ethyl-2-pyridine-2-carboxamide)manganese(II)  0   *Organometallic Compounds Manganese. Inorg Chem 2004 May 3;43(9):2988-97
mu-oxo-bis(5,10,15,20-tetra(p-methylphenyl)porphinatomanganese(III))  0   *Metalloporphyrins Manganese. Anal Sci. 2006 Jul;22(7):949-53
manganese-hydroxypropyl-tetraacetic acid  0   *Organometallic Compounds Contrast Media Manganese. J Magn Reson Imaging 2006 Oct;24(4):858-63
aquabromo(mu-acetato)(mu-methoxo)(1,5-bis(5-methylsalicylidenamino)pentan-3-ol)dimanganese(III)  0   *Organometallic Compounds Manganese. Dalton Trans 2006 Nov 21;(43):5156-66
(mu-acetato)(mu-methoxo)bis(methanol)(1,5-bis(3-methylsalicylidenamino)pentan-3-ol)dimanganese(III)  0   *Organometallic Compounds Manganese. Dalton Trans 2006 Nov 21;(43):5156-66
CMC-001  0   *Manganese. Acad Radiol 2005 May;12 Suppl 1:S21-3
Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin  0   *Metalloporphyrins Manganese. Free Radic Res 2005 Jan;39(1):81-8
(MnIV4O5(terpy)4(H2O)2)(ClO4)6  0   *Organometallic Compounds Manganese. J Am Chem Soc 2004 Jun 16;126(23):7206-11
lithium manganese oxide  0   *Lithium *Manganese *Oxides. J Nanosci Nanotechnol 2004 Jan-Feb;4(1-2):162-6
EVP 1001-1  0   *Manganese. Invest Radiol 2003 Oct;38(10):642-52
bis(3,5-di-t-butyl-1,2-benzoquinone 1-oximato)manganese(II)  0   *Organometallic Compounds *Benzoquinones Manganese. Spectrochim Acta A Mol Biomol Spectrosc. 2003 Apr;59(6):1151-60
EUK 207  0   *Organometallic Compounds Manganese. Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8526-31
6,7-dicycanodipyridoquinoxaline manganese(II) complex  0   *Organometallic Compounds *Quinoxalines Manganese. Inorg Biochem 2002 Nov 25;92(3-4):149-55
manganese(III)-tetra(4-carboxyphenyl)porphine  0   *Metalloporphyrins Manganese. Anal Sci 2003 Apr;19(4):569-73
Mn(IV)-Me4DTNE  0   *Organometallic Compounds Manganese. J Agric Food Chem 2003 Mar 26;51(7):1932-41
2-hydroxy-1-naphthaldehyde-2-amino-5-phenylthiazole manganese  0   *Organometallic Compounds Manganese. J Agric Food Chem 2003 Mar 26;51(7):1761-4
EVP-ABD  0   *Manganese. J Magn Reson Imaging 2002 Dec;16(6):668-75
(Fe(III)Mn(II)(BPBPMP)(OAc)(2))ClO(4)  0   *Ferric Compounds Manganese. Inorg Chem 2002 Sep 9;41(18):4624-6
manganese ethylenebis(dithiocarbamate)  0   *Ethylenebis(dithiocarbamates) *Organometallic Compounds Manganese. J Neurochem 2003 Jan;84(2):336-46
(8,12-diethyl-2,3,7,13,17,18-hexamethylcorrolato)manganese(III)  0   *Organometallic Compounds Manganese. Spectrochim Acta A Mol Biomol Spectrosc 2002 Apr;58(6):1113-27
manganese(III) tris(hexafluoroacetylacetonate)  0   *Organometallic Compounds Manganese. Inorg Chem 2002 May 20;41(10) (2769-76)
poly(binaphthyl salen manganese complex)  0   *Organometallic Compounds Antioxidants Manganese. Chirality 2002 Jul;14(7):587-90
Mn(II)2H-5-hydroxy-1,2,5-oxadiazo(3,4-f)1,10-phenanthroline  0   *Organometallic Compounds Manganese. J Inorg Biochem 2002 Jun 7;90(3-4):79-84
triaqua(2,2'-bipyridine-N,N')(nitrato-O)manganese(II) nitrate  0   *Organometallic Compounds Manganese. Acta Crystallogr C 2002 Apr;58(Pt 4):m268-9
tetrakis((4-aminopyridinio)acetato-kappaO)diaquamanganese(II)  0   *Aminopyridines *Organometallic Compounds Manganese. Acta Crystallogr C 2002 Mar;58( Pt 3):m188-9
HOP-8P  0   *Metalloporphyrins Manganese. Magn Reson Med 2002 Mar;47(3):549-53
acetatobis((bis(2-benzimidazolylmethyl)amino)ethanol)manganese(III)acetatomanganese(III)  0   *Organometallic Compounds Manganese. J Inorg Biochem 2001 Sep;86(2-3):573-9
AEOL11201  0   *Metalloporphyrins Manganese. Dig Dis Sci 2001 Oct;46(10):2222-30
bis(mu-benzoato-O:O')bis(3-(3-methoxysalicydeneamino)propanolato-O,N,O':O')dimanganese(III)  0   *Organometallic Compounds Manganese. Acta Crystallogr C 2001 Jun;57(Pt 6):719-20
HOP-9P  0   *Metalloporphyrins Manganese. Br J Cancer 2001 Jun 15;84(12):1681-5
manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin  0   *Metalloporphyrins Antioxidants Manganese. J Neurosci 2001 Jul 1;21(13):4582-92
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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