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Guanidine

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Definition: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.      Other names Sulfate, Guanidine; Phosphate, Guanidine; Nitrate, Guanidine; Monohydroiodine, Guanidine; Monohydrochloride, Guanidine; Monohydrobromide, Guanidine; Monohydrate, Guanidine; Hydrochloride, Guanidine; Chloride, Guanidium; Chloride, Guanidinium; Guanidium Chloride; Guanidine Sulfite (1:1); Guanidine Sulfate (2:1); Guanidine Sulfate (1:1); Guanidine Sulfate; Guanidine Phosphate; Guanidine Nitrate; Guanidine Monohydroiodine; Guanidine Monohydrochloride; Guanidine MonohydrobromideDrugs* : GUANIDINE HYDROCHLORIDE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
synoxazolidinone B  0   *Oxazolidinones Guanidine/*analogs & derivatives. Org Lett. 2010 Nov 5;12(21):4752-5
synoxazolidinone A  0   *Oxazolidinones Guanidine/*analogs & derivatives. Org Lett. 2010 Nov 5;12(21):4752-5
monanchocidin  0   Guanidine/*analogs & derivatives Alkaloids. Org Lett. 2010 Oct 1;12(19):4292-5
4,5-biphenyl-2-pyrimidinylguanidine  0   *Biphenyl Compounds Guanidine/*analogs & derivatives. J Comb Chem. 2009 Sep-Oct;11(5):880-5
1,1'-((1S,3R,4S,6R)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl)diguanidinium sulfate monohydrate  0   *Cyclohexanes Guanidine/*analogs & derivatives. Acta Crystallogr C. 2009 Jun;65(Pt 6):o290-2
canarosine  0   Guanidine/*analogs & derivatives Alkaloids. J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):915-8
N,N'-bis(guanidinoethyl)-2,6-pyridinedicarboxamide  0   *Pyridones Guanidine/*analogs & derivatives. Bioconjug Chem. 2008 Sep;19(9):1840-8
(1-((5-methyl-3-(2-methylsulfonylphenylsulfonyloxy)phenoxyl)methyl) cyclopropylmethoxy)guanidine hydrochloride  0   Guanidine/*analogs & derivatives. Biopharm Drug Dispos 2008 Apr;29(3):127-38
diguanidine  0   *Furans Guanidine/*analogs & derivatives. Biochem Pharmacol 2007 Jun 15;73(12):1939-46
meta-((211)At)astatobenzylguanidine  0   Guanidine/*analogs & derivatives Astatine. Bioorg Med Chem. 2007 May 15;15(10):3430-6
crambidine  0   *Spiro Compounds Guanidine/*analogs & derivatives. J Am Chem Soc. 2005 Nov 9;127(44):15394-6
neonicotinoid nitroguanidine  0   Guanidine/*analogs & derivatives Anabasine. Chem Res Toxicol. 2005 Sep;18(9):1479-84
N,N-diethyl-N-(4-hydroxy-6-methylpyridin-2-yl)guanidine  0   Guanidine/*analogs & derivatives. Anal Sci. 2004 Oct;20(10):1427-31
crambescin A  0   Guanidine/*analogs & derivatives Alkaloids. Org Biomol Chem. 2004 Jul 21;2(14):2003-11
batzelladine B  0   Guanidine/*analogs & derivatives Alkaloids. Org Biomol Chem. 2004 Jul 21;2(14):2003-11
crambescidin 800  0   *Spiro Compounds Guanidine/*analogs & derivatives Alkaloids. Anticancer Res. 2004 Jul-Aug;24(4):2325-30
4-(4-methylbenzyl)-4'-(guanidinomethylbenzoyloxy) biphenyl-4-carboxylate hydrochloride  0   *Biphenyl Compounds Guanidine/*analogs & derivatives. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2703-7
chlorophenylguanidine  0   Guanidine/*analogs & derivatives. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1119-23
butyl-1,1,3,3-tetramethylguanidine  0   Guanidine/*analogs & derivatives. Org Lett. 2003 Apr 3;5(7):1155-8
Cocospropylenediamine-guanidinium diacetate  0   Guanidine/*analogs & derivatives. Contact Dermatitis 2002 Mar;46(3):176
N-cyano-N'-(tert-pentyl)-N''-(3-pyridinyl) guanidine  0   *Guanidine. J Urol 2002 Jun;167(6):2618-23
N-(2-amino-5-chloro-4-nitrobenzoyl)-N'-(1-naphtylmethyl)guanidine  0   Guanidine/*analogs & derivatives. Eur J Med Chem 2001 Jul-Aug;36(7-8):597-614
batzelladine F  0   *Alkaloids Guanidine/*analogs & derivatives. J Am Chem Soc 2001 Oct 31;123(43):10782-3
N-succinimidyl 4-guanidinomethyl-3-iodobenzoate  0   *Benzoates Guanidine/*analogs & derivatives.
sulfonylguanidine  0   Guanidine/*analogs & derivatives. J Med Chem 2000 May 4;43(9):1793-806
dihydrated bis(aminoguanidinium(1+))hexafluorosilicate  0   Guanidine/*analogs & derivatives. Acta Crystallogr B 1999 Apr 1;55(Pt 2):246-54
ferroelectric ammonioguanidinium(2+)hexafluorozirconate  0   Guanidine/*analogs & derivatives. Acta Crystallogr B 1999 Apr 1;55(Pt 2):246-54
anhydrous ammonioguanidinium(2+)  0   Guanidine/*analogs & derivatives. Acta Crystallogr B 1999 Apr 1;55(Pt 2)
guanidine carboxamide  141-83-3   Urea/*analogs & derivatives Guanidine/*analogs & derivatives. Arzneim Forsch 1981;31(2):288

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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