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p38 Mitogen-Activated Protein Kinases

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Definition: A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.      Other names p38 Mitogen Activated Protein Kinases; Protein Kinase, p38; Mitogen Activated Protein Kinase p38; MAPK, p38; MAP Kinase, p38; p38 SAPK; p38 Protein Kinase; p38 MAP Kinase; p38 MAPK; Mitogen-Activated Protein Kinase p38
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PF 03715455  0   *Methylurea Compounds *Azabicyclo Compounds p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem. 2011 Nov 24;54(22):7797-814.
A 304000  0   *Indoles *Pyridines p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Biol Chem 2002 Dec 27;277(52):50386-95
DP 802  0   *Phenylurea Compounds *Pyrazoles p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Oct 1;20(19):5793-8
(1,3-dihydroxyprop-2-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl)imidazole  0   *Imidazoles *Pyrimidines p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Dec;307(3):932-8
N-cyclopropyl-3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido(3,2-d)pyridazin-3-yl)-4-methylbenzamide  0   *Pyridazines *Pyridones p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2010 Sep 9;53(17):6398-411
PHA 666859  0   *Pyrazoles *Pyrimidines p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. Invest Ophthalmol Vis Sci 2010 Apr;51(4):2158-64
PH 797804  0   *Benzamides *Pyridones p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. Biochemistry 2009 Jul 14;48(27):6402-11
N-cyano-N'-(2-((8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido(2,3-d)pyrimidin-2-yl)amino)ethyl)guanidine  0   *Guanidines *Pyrimidinones p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2009 Feb;328(2):458-68
pamapimod  0   *Pyridones *Pyrimidines p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2008 Dec;327(3):610-9
Org 48762-0  0   *Pyridines p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2007 Jan 25;50(2):283-93
1-(5-(4-chlorophenyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl)-4-methylpiperazine  0   *Piperazines *Pyrazoles p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2007 Nov 15;50(23):5712-9
3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one  0   *Quinolones p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2007 Mar 22;50(6):1213-21
7-amino-5-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-1,6-naphthyridin-1H-2-one  0   *Naphthyridines p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. Bioorg Med Chem Lett 2006 Oct 15;16(20):5468-71
indole-5-carboxamide  0   *Indoles p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. Proc Natl Acad Sci U S A 2002 Feb 5;99(3):1610-5
N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide  0   *Benzamides *Thiazoles Tumor Necrosis Factor-alpha/antagonists & inhibitors p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. Proc Natl Acad Sci U S A 2005 Sep 20;102(38):5966-79
N-(4-(5-(4-fluorophenyl)-3-(2-methoxyethyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)acetamide  0   *Aminopyridines *Imidazoles p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2004 Dec 2;47(25):6311-25
N-methoxy-4-methyl-3-(4-(methyl(neopentyl)amino)-6-(4-methyl-1,4-diazepan-1-yl)-1,3,5-triazin-2-ylamino)benzamide  0   *Benzamides *Triazines p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2004 Dec 2;47(25):6283-91

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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