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Receptor, Muscarinic M3

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Definition: A subclass of muscarinic receptor that mediates cholinergic-induced contraction in a variety of SMOOTH MUSCLES.      Other names Receptors M3, Muscarinic; Receptor M3, Muscarinic; Muscarinic M3 Receptors; Muscarinic M3 Receptor; M3, Muscarinic Receptors; M3, Muscarinic Receptor; M3 Receptors, Muscarinic; M3 Receptor, Muscarinic; Receptors, Muscarinic M3; Muscarinic Receptors M3; Muscarinic Receptor M3Drugs* : VESICARE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AZD9164  0   *Piperidines *Quinuclidines Receptor, Muscarinic M3/antagonists & inhibitors. Bioorg Med Chem Lett. Dec 15;21(24):7440-6.
5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide  0   *Azetidines *Diphenylacetic Acids Receptor, Muscarinic M3/antagonists & inhibitors. J Med Chem. 2011 Oct 13;54(19):6888-904.
3-((((3-fluorophenyl)((3,4,5-trifluorophenyl)methyl)amino)carbonyl)oxy)-1-(2-oxo-2-(2-thienyl)ethyl)-1-azoniabicyclo(2.2.2)octane  0   *Carbamates *Quinuclidines Receptor, Muscarinic M3/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Dec;335(3):622-35
(3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo( 3.2.1)octane bromide  0   *Biphenyl Compounds *Bicyclo Compounds, Heterocyclic Receptor, Muscarinic M3/antagonists & inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4560-2
4-(hydroxy(diphenyl)methyl)-1-(2-((phenylmethyl)oxy)ethyl)-1-azoniabicyclo(2.2.2)octane  0   *Benzhydryl Compounds *Quinuclidines Receptor, Muscarinic M3/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2493-505
1-(4-hydroxy-1-(3,3,3-tris(4-fluorophenyl)propanoyl)pyrrolidine-2-yl)carbonyl-N-(4-piperidinylmethyl)pyrrolidine-2-carboxamide  0   *Dipeptides *Trityl Compounds Receptor, Muscarinic M3/antagonists & inhibitors. J Med Chem 2006 Sep 21;49(19):5653-63
nocardimicin I  0   *Hydroxamic Acids *Oxazoles Receptor, Muscarinic M3/antagonists & inhibitors. J Antibiot (Tokyo) 2005 Sep;58(9):566-72
nocardimicin G  0   *Hydroxamic Acids *Oxazoles Receptor, Muscarinic M3/antagonists & inhibitors. J Antibiot (Tokyo) 2005 Sep;58(9):566-72
nocardimicin H  0   *Hydroxamic Acids *Oxazoles Receptor, Muscarinic M3/antagonists & inhibitors. J Antibiot (Tokyo) 2005 Sep;58(9):566-72
darifenacin  133099-04-4   *Benzofurans *Pyrrolidines Urinary Incontinence Receptor, Muscarinic M3.
Pharma Action Muscarinic Antagonists 		Anal Chem 1996 May 1;68(9):1658-60ENABLEX

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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