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Diphenhydramine

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Definition: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.     
Pharmacological Action Anesthetics, Local; Anti-Allergic Agents; Antiemetics; Histamine H1 Antagonists; Hypnotics and Sedatives
Examples Dimenhydrinate 		Other names Diphenylhydramin; Benhydramin; Hydrochloride, Diphenhydramine; Citrate, Diphenhydramine; Diphenylhydramine; Diphenhydramine Hydrochloride; Diphenhydramine Citrate (1:1); Diphenhydramine Citrate; Dimedrol; Benzhydramine; Benylin; Benadryl; Allerdryl; 2-Diphenylmethoxy-N,N-dimethylethylamineDrugs* : ADVIL PM; DIPHENHYDRAMINE HYDROCHLORIDE; SILPHEN; IBUPROFEN AND DIPHENHYDRAMINE HYDROCHLORIDE; BENADRYL PRESERVATIVE FREE; DIBENIL; BENYLIN; HYDRAMINE; BENADRYL; VICKS FORMULA 44; ANTITUSSIVE; IBUPROFEN AND DIPHENHYDRAMINE CITRATE; BELDIN; DIPHENHYDRAMINE HYDROCHLORIDE PRESERVATIVE FREE; DIPHEN; BELIX
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
desmethyldiphenhydramine  0   Diphenhydramine/*analogs & derivatives. Forensic Sci Int 2006 Sep 12;161(2-3):189-97
Somnium  119177-41-2   *Diphenhydramine *Lorazepam Drug Combinations. Schweiz Rundsch Med Prax 1992 Jun 16;81(25):838-40
Poly-5  0   *Cimetidine *Diphenhydramine *Ibuprofen *Ketanserin *Methylprednisolone Drug Combinations. J Trauma 1987;27(12):1313
monodesmethyldiphenhydramine  17471-10-2   Diphenhydramine/*analogs & derivatives. J Clin Pharmcol 1986;26(7):529
Propain  138230-30-5   *Acetaminophen *Caffeine *Codeine *Diphenhydramine Drug Combinations. Br J Clin Pract 1985;39(1):21
Sedyn-A-forte  87413-60-3 Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt, mixt. with 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one and 2-(diphenylmethoxy)-N,N-dimethylethanamine  *Diazepam *Diphenhydramine *Dipyrone Drug Combinations. Indian J Ophthalmol 1982;30(4):271
Pellit  84750-08-3 1,2-Benzenedicarboxylic acid, dimethyl ester, mixt. with N,N-diethyl-3-methylbenzamide and 2-(diphenylmethoxy)-N,N-dimethylethanamine  *DEET *Diphenhydramine *Phthalic Acids Drug Combinations. Arzneimittelforsch 1983;33(1):169
aminophylline, cycloclenbutrerol, diphenydramine, phenobarbital drug combination  0   *Aminophylline *Diphenhydramine *Phenobarbital Clenbuterol/*analogs & derivatives Drug Combinations Asthma/drug therapy. Chung Hua Chieh Ho Ho Hu Hsi Hsi Chi Ping Tsa Chih 1982;4(6):333
despa-kowa  82824-05-3 Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-, mixt. with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide and 2-(diphenylmethoxy)-N,N-dimethylethanamine 2-hydroxybenzoate (1:1)  *Benzalkonium Compounds *Chlorhexidine Diphenhydramine/*analogs & derivatives Drug Combinations Hydrocortisone/*analogs & derivatives. Dental Outlook (Jpn) 1982;59(3):619
Neo-fluvaleas  79682-27-2 Benzenepropanaminium, gamma-(aminocarbonyl)-N-methyl-N,N-bis(1-methylethyl)-gamma-phenyl-, iodide, mixt. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione, (S-(R*,S*))-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinoli  *Acetaminophen *Quaternary Ammonium Compounds *Diphenhydramine *Noscapine Drug Combinations. Arch Sci Med (Torino) 1980;137(2):321
dolo visano  76404-04-1 Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-, phosphate (1:1) (salt), mixt. with 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one, 2-(diphenylmethoxy)-N,N-dimethylethanamine hydrochloride, 2-methyl-2  *Aspirin *Codeine *Diphenhydramine *Meprobamate *Nicotinic Acids Drug Combinations. Fortschr Med 97(16):791;1979
diphenhydramine, meprobamate, nicotinic acid, pentaerythritol tetranitrate, drug combination  0   *Diphenhydramine *Meprobamate *Nicotinic Acids *Pentaerythritol Tetranitrate Drug Combinations. Fortschr Med 1981;99(41):1714
antigrippen  76721-94-3 L-Ascorbic acid, mixt. with 2-(acetyloxy)benzoic acid, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one, 2-(diphenylmethoxy)-N,N-dimethylethanamine hydrochloride and 2-hydroxy  *Ascorbic Acid *Aspirin *Diphenhydramine *Rutin Drug Combinations. Farmatsiia 24(1):66;1975
bromodiphenhydramine  118-23-0   Diphenhydramine/*analogs & derivatives. J Chromatogr Sci 13(12):563;1975AMBENYL; AMBODRYL; BROMANYL; BROMODIPHENHYDRAMINE HYDROCHLORIDE AND CODEINE PHOSPHATE
sagittacin  79329-86-5 Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride, mixt. with (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphth  *Diphenhydramine *Guaifenesin *Tetracycline *Thiamine Drug Combinations. Z Allgemeinmed 49(21):1011;1973
prothidryl  8075-77-2   Diphenhydramine/*analogs & derivatives.
peroben  78371-63-8 2,4(1H,3H)-Pyridinedione, 3,3-diethyl-, mixt. with 2-(diphenylmethoxy)-N,N-dimethylethanamine  *Diphenhydramine *Pyridones Drug Combinations. Dermatologica 158(6):417;1979; Praxis 63(6):157;1974
moxastine theoclate  21661-62-1   Diphenhydramine/*analogs & derivatives Theophylline/*analogs & derivatives. Am J Clin Pathol 62(1):82;1974
embraminteoclat  25454-97-1 2-(p-bromo-alpha-methyl-alpha-phenylbenzyloxy)-N,N-dimethylethylamine cpd with 8-chloro theophylline  Diphenhydramine/*analogs & derivatives Theophylline/*analogs & derivatives. Cesk Gastroenterol 25(5):204;1971
embramine  3565-72-8 2-(p-bromo-alpha-methyl-alpha-phenylbenzyloxy)-N,N-dimethylethyl amine  Diphenhydramine/*analogs & derivatives.
Mandrax  8076-99-1   *Diphenhydramine *Methaqualone Drug Combinations.
Lomapect  0   *Diphenhydramine *Oxadiazoles Drug Combinations. Med Welt 46:1855;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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