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Cimetidine

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Definition: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRINS output. It also blocks the activity of CYTOCHROME P-450 which might explain proposals for use in NEOADJUVANT THERAPY.     
Pharmacological Action Anti-Ulcer Agents; Enzyme Inhibitors; Histamine H2 Antagonists 		Other names SKF92334; SKF 92334; SK&F92334; SK&F 92334; Hydrochloride, Cimetidine; HCl, Cimetidine; Tagamet; SKF-92334; SK&F-92334; N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4; Histodil; Eureceptor; Cimetidine Hydrochloride; Cimetidine HCl; Biomet400; Altramet; BiometDrugs* : CIMETIDINE HYDROCHLORIDE; CIMETIDINE HYDROCHLORIDE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER; TAGAMET HB 200; TAGAMET; CIMETIDINE; TAGAMET HB; TAGAMET HYDROCHLORIDE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
VUF5420  0   Cimetidine/*analogs & derivatives. Neuropharmacology 2006 Sep;51(3):447-56
SKF 92374  0   Cimetidine/*analogs & derivatives. J Pharmacol Exp Ther 1996 Feb;276(2):500
Poly-5  0   *Cimetidine *Diphenhydramine *Ibuprofen *Ketanserin *Methylprednisolone Drug Combinations. J Trauma 1987;27(12):1313
copper(II)-cimetidine complex  0   *Cimetidine *Organometallic Compounds Copper. Acta Physiol Pharmacol Bulg 1987;13(2):48
copper(II)-cimetidine-alanine complex  115586-22-6   *Alanine Cimetidine Copper. J Inorg Biochem 1987;29(2):119
isocimetidine  104057-02-5   Cimetidine/*analogs & derivatives. Arzneimittelforschung 1985;35(8):1223
hydroxymethyl cimetidine  59359-50-1   Cimetidine/*analogs & derivatives. J Chromatogr 1985;339(1):139
guanylurea cimetidine  77076-18-7   Cimetidine/*analogs & derivatives. J Chromatogr 1985;339(1):139
N-desmethylcimetidine  52378-43-5   Cimetidine/*analogs & derivatives. Biopharm Drug Dispos 1984;5(4):415
aluminum hydroxide, cimetidine, cocaine, hydroxyzine, morphine drug combination  0   *Aluminum Hydroxide *Cimetidine *Cocaine *Hydroxyzine *Morphine Drug Combinations. Compr Ther 1984;10(5):48
cimetidine sulfoxide  54237-72-8   Cimetidine/*analogs & derivatives. Drug Metab Dispos 1982;10(3):289
tiotidine  69014-14-8 N-(2-(((2-((aminoiminomethyl)amino)-4-thiazoyl) methyl)thio)ethyl)-N'-cyano-N''-methylguanidine  Cimetidine/*analogs & derivatives.
Pharma Action Histamine H2 Antagonists 		Life Sci 25(23):2001;1979
nitrosocimetidine  73785-40-7 Guanidine, N'-cyano-N-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-N-nitroso  Cimetidine/*analogs & derivatives. Lancet 1(8124):1005;1979; Toxicology 1979;15(1):69

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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