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Diazepam

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Definition: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.     
Pharmacological Action Adjuvants, Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anticonvulsants; Antiemetics; GABA Modulators; Hypnotics and Sedatives; Muscle Relaxants, Central
See Also Receptors, GABA-A
Examples Nordazepam 		Other names Valium; Stesolid; Sibazon; Seduxen; Relanium; Faustan; Diazemuls; Apaurin; 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzDrugs* : VALIUM; DIZAC; DIASTAT; Q-PAM; DIASTAT ACUDIAL; VALRELEASE; DIAZEPAM; DIAZEPAM INTENSOL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SH-053-2'F-R-CH3  0   *Imidazoles Diazepam/*analogs & derivatives. Neuropharmacology. 2010 Dec;59(7-8):612-8.
8-hydroxyetizolam  0   Diazepam/*analogs & derivatives. Forensic Sci Int 2008 Nov 20;182(1-3):e1-6
4'-chlordiazepam  0   Diazepam/*analogs & derivatives. Indian J Physiol Pharmacol 2003 Jul;47(3):288-96
2'-iododiazepam  123847-23-4   Diazepam/*analogs & derivatives Iodine Radioisotopes. J Nucl Med 1993 Jun;34(6):932-7
alpha-hydroxyetizolam  64546-10-7   Diazepam/*analogs & derivatives. Eur J Clin Pharmacol 1991;40(2):181
pro-diazepam  65617-86-9   *Dipeptides Diazepam. J Pharm Pharmacol 1990;42(4):247
4'-hydroxydiazepam  17311-35-2 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl  Temazepam Diazepam/*analogs & derivatives. Life Sci 1986;39(1):17
4'-hydroxydesmethyldiazepam  17270-12-1 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)  Diazepam/*analogs & derivatives. Life Sci 1986;39(1):17
etizolam  40054-69-1   Diazepam/*analogs & derivatives.
Pharma Action Tranquilizing Agents 		Jpn J Pharmacol (Suppl)24:113; 1974; Minerva Psichiatr 1984;25(4):269; Psychopharmacologia 44(2):165;1975
4-carbamoyl-4,5-dihydrodiazepam  86636-97-7 4H-1,4-Benzodiazepine-4-carboxamide, 7-chloro-1,2,3,5-tetrahydro-1-methyl-2-oxo-5-phenyl-, (+-)  Diazepam/*analogs & derivatives. Experientia 1983;39(6):591
Sedyn-A-forte  87413-60-3 Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt, mixt. with 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one and 2-(diphenylmethoxy)-N,N-dimethylethanamine  *Diazepam *Diphenhydramine *Dipyrone Drug Combinations. Indian J Ophthalmol 1982;30(4):271
Seda-Presomen  81296-87-9 Seda-presomen  *Diazepam *Estrogens, Conjugated (USP) Drug Combinations. Acta Univ Palacki Olomuc Fac Med 1981;101:139
4,5-dihydrodiazepam  2619-57-0   Diazepam/*analogs & derivatives. Experientia 1980;36(9):1031
reladorm  71789-18-9 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohexen-1-yl)-5-ethyl-, calcium salt (2:1), mixt. with 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one  *Barbiturates *Diazepam Drug Combinations. Mater Med Pol 11(2):173;1979
2-chlorodiazepam  2894-68-0 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl  *Benzodiazepines Diazepam/*analogs & derivatives. Life Sci 25(1):15;1979
Silentan  79084-81-4 Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha,10alpha)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (2:1) (salt), mixt. with 2-(acetyloxy)benzoic acid, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2  *Aspirin *Caffeine *Diazepam *Dihydroergotamine Drug Combinations. MMW 121(10):355;1979
fosazepam  35322-07-7 7-chloro-1-(dimethylphosphinmethyl)-5-phenyl-1,3- dihydro-2H-1,4-benzodiazepin-2-one  Diazepam/*analogs & derivatives. Br J Clin Pharm 4(4):494;1977; Br J Pharmacol 55(2):262P;1975; Europ J Clin Pharmacol 12:105;1977
valpinax  78891-89-1 8-Azoniabicyclo(3.2.1)octane, 8,8-dimethyl-3-((1-oxo-2-propylpentyl)oxy)-, bromide, endo-, mixt. with 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one  *Diazepam *Tropanes Drug Combinations. Minerva Gastroenterol 20(1):27;1974
gefarnax  77416-72-9 4,8,12-Tetradecatrienoic acid, 5,9,13-trimethyl-, 3,7-dimethyl-2,6-octadienyl ester, (E,E,E)-, mixt. with 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one  *Diazepam *Gefarnate Drug Combinations. Minerva Med 64(87):4583;1973
fludiazepam  3900-31-0 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one  *Benzodiazepines Diazepam/*analogs & derivatives. Arzneim Forsch 24(10):1563;1974; Arzneim Forsch 25(5):755;1975; J Pharm Pharmacol 30(1):56;1978; J Pharm Pharmacol 30(4):254;1978; Jpn J Pharm 27:905;1977; Jpn J Pharmacol 26:411;1976; Jpn J Pharmacol 27:517;1977; Psychopharmacology 58(3):217;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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