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Dizocilpine Maleate

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Definition: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.  DF: note short X   
Pharmacological Action Excitatory Amino Acid Antagonists; Neuroprotective Agents 		Other names Dizocilpine; MK801; MK 801; MK-801
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cyano-diczocilpine  0   *Nitriles Dizocilpine Maleate/*analogs & derivatives. J Neurochem 2001 Aug;78(3):417-23
3-iododizocilpine  119508-63-3   Dizocilpine Maleate/*analogs & derivatives Iodine Radioisotopes. Nucl Med Commun 1997 Feb;18(2):149-58
3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine  149818-12-2   Dizocilpine Maleate/*analogs & derivatives. J Med Chem 1993 Aug 20;36(17):2499-507
2-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine  149715-73-1   Dizocilpine Maleate/*analogs & derivatives. J Med Chem 1993 Aug 20;36(17):2499-507
5-aminocarbonyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine  124070-15-1   Dizocilpine Maleate/*analogs & derivatives. J Pharmacol Exp Ther 1991;259(1):30
5-fluoromethyl MK 801  119493-73-1   Dizocilpine Maleate/*analogs & derivatives. Neurosci Lett 1991;121(1-2):183
3-azido-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine  127627-58-1   *Azides Dizocilpine Maleate/*analogs & derivatives Receptors, N-Methyl-D-Aspartate. J Biol Chem 1990;265(12):6776
1-iodo-MK 801  119493-70-8   Dizocilpine Maleate/*analogs & derivatives. Pharm Res 1989;6(6):474
N-cyclopropylmethyl-10,11-dihydro-5H-dibenzo-(a,d)-cyclohepten-5-imine  59864-46-9 Cyclopropanemethanamine, N-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)  Dizocilpine Maleate/*analogs & derivatives. Brit J Pharmacol 63:183;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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