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Epothilones
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Definition
: A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).
Pharmacological Action
Tubulin Modulators
Other names
Epothilone; Epothilon
Substance
CAS Registry & name
Categories
Source
Drugs
*
KOS-
1584
0
*Epothilones
Antineoplastic Agents.
Cancer Chemother Pharmacol. 2012 Feb;69(2):523-31
12,13-
cyclopropyl-
epothilone B
0
*Epothilones.
Org Lett. 2011 Mar 18;13(6):1436-9
C26-
hydroxyepothilone D
0
*Epothilones.
J Org Chem. 2010 Jan 1;75(1):86-94
10,14-
dihydroxy-
9,11,13,13-
tetramethyl-
2-
(1-
methyl-
2-
(2-
methyl-
thiazol-
4-
yl)-
vinyl)-
5-
(7-
nitro-
benzo(1,2,5)oxadiazol-
4-
yl)-
1-
oxa-
5-
aza-
cyclohexadecane-
12,16-
dione
0
*Epothilones
4-Chloro-7-nitrobenzofurazan/*analogs & derivatives.
Chembiochem 2009 Oct 12;10(15):2513-21
(S)-
14-
methoxyepothilone
0
*Epothilones.
Org Lett. 2009 Aug 6;11(15):3186-9
AV-
EPO-
106
0
*Epothilones.
Biomed Chromatogr. 2009 Mar;23(3):302-7
sagopilone
0
*Epothilones
*Benzothiazoles.
Cancer Res 2008 Jul 1;68(13):5301-8
cryptothilone 1
0
*Epothilones.
Org Lett 2006 Aug 31;8(18):3947-50
fludelone
0
*Epothilones.
Cancer Res. 2005 Oct 15;65(20):9445-54
26-
trifluoro-
(E)-
9,10-
dehydro-
12,13-
desoxyepothilone B
0
*Epothilones.
J Am Chem Soc. 2004 Sep 8;126(35):10913-22
BMS 310705
0
*Epothilones.
Gynecol Oncol. 2003 Oct;91(1):173-8
epothilone 490
0
*Thiazoles
*Epothilones.
J Am Chem Soc 2002 Aug 21;124(33):9825-32
10,11-
didehydroepothilone D
0
*Thiazoles
*Epothilones.
J Nat Prod 2002 Jul;65(7):1061-4
9,10-
dehydroepothilone D
0
*Epothilones.
J Am Chem Soc 2001 Jun 13;123(23):5407-13
epothilone I
0
*Epothilones.
J Nat Prod 2001 Jul;64(7):847-56
epothilone K
0
*Epothilones.
J Nat Prod 2001 Jul;64(7):847-56
ixabepilone
219989-84-1
*Epothilones
Tubulin Modulators.
Clin Cancer Res 2001 May;7(5):1429-37
IXEMPRA KIT
epothilone F
0
*Epothilones.
Chemistry 2001 Apr 17;7(8):1691-702
epothilone C
0
*Epothilones.
Chemistry 2001 Apr 17;7(8):1691-702
epothilone C-
D monooxygenase
EC 1.13.12.-
*Oxygenases
Epothilones.
J Antibiot (Tokyo) 2001 Feb;54(2):144-8
12,13-
desoxyepothilone F
0
*Epothilones.
J Org Chem 2000 Oct 6;65(20):6525-33
15-
aza-
12,13-
desoxyepothilone B
0
*Epothilones.
Org Lett 2000 Jan 1;2(11):1637-9
epothilone E
0
*Epothilones.
Bioorg Med Chem1999 May;7(5):665-97
desoxyepothilone B
0
*Epothilones
Tubulin Modulators.
Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9642-7
C12,13-
cyclopropylepothilone A
0
*Epothilones.
Chem Biol 1998 Jul;5(7):365-72
desoxyepothilone A
0
*Epothilones.
Proc Natl Acad Sci U S A 1998 Feb 17;95(4):1369-74
epothilone B
0
*Epothilones.
Pharma Action
Antineoplastic Agents
;
Tubulin Modulators
Cancer Res 1995 Jun 1;55(11):2325-33
epothilone A
0
*Epothilones.
Pharma Action
Antineoplastic Agents
;
Tubulin Modulators
Cancer Res 1995 Jun 1;55(11):2325-33