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Colchicine
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Definition
: A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
Pharmacological Action
Gout Suppressants
;
Tubulin Modulators
Examples
Demecolcine
;
Lumicolchicines
Other names
Colchicine, (R)-
Isomer; Colchicine, (+-
)-
Isomer
Drugs
*
:
COLCRYS
Substance
CAS Registry & name
Categories
Source
Drugs
*
NSC 51046
0
Colchicine/*analogs & derivatives.
J Org Chem. 2010 Dec 3;75(23):8241-51
188Re(CO)3-
colchicine iminodiacetic acid
0
*Coordination Complexes
Colchicine/*analogs & derivatives
Rhenium.
Cancer Biother Radiopharm 2008 Dec;23(6):741-8
CT20126
0
Colchicine/*analogs & derivatives.
Exp Mol Med 2007 Apr 30;39(2):230-8
3-
desmethylthiocolchicine
0
Colchicine/*analogs & derivatives.
J Chromatogr A 2002 Mar 8;949(1-2):71-7
3-
O-
demethylcolchicine-
3-
O-
glucopyranoside
0
*Glucosides
Colchicine/*analogs & derivatives.
Nat Prod Lett 2001;15(4):217-9
colchicone
0
Colchicine/*analogs & derivatives.
Oncol Res 1999;11(3):145-52
THC 18
0
Colchicine/*analogs & derivatives.
Biochem Biophys Res Commun 1999 Jan 19;254(2):334-7
THC 5
0
Colchicine/*analogs & derivatives.
Biochem Biophys Res Commun 1999 Jan 19;254(2):334-7
1,2,3-
O-
acetyl-
1,2,3-
demethyl-
N-
(4'-
nitrobenzoyl)deacetylthiocolchicine
0
Colchicine/*analogs & derivatives
DNA Topoisomerases, Type II/antagonists & inhibitors.
J Med Chem 1998 May 21;41(11):1956-61
tridemethyl-
N-
(4'-
nitrobenzoyl)deacetylthiocolchicine
0
Colchicine/*analogs & derivatives
DNA Topoisomerases, Type II/antagonists & inhibitors.
J Med Chem 1998 May 21;41(11):1956-61
colchicide
518-15-0
Colchicine/*analogs & derivatives.
Biochem J 1997 Nov 1;327(Pt 3):685-8
4-
formylcolchicine
2730-82-7
Colchicine/*analogs & derivatives.
Biotechnol Appl Biochem 1995 Aug;22( Pt 1):15-22
N-
deacetyl-
N-
formylcolchicine
7411-12-3
Colchicine/*analogs & derivatives.
Eur J Drug Metab Pharmacokinet 1992 Oct-Dec;17(4):243-6
2,3-
didemethylcolchicine
57866-21-4 Acetamide, N-
(5,6,7,9-
tetrahydro-
2,3-
dihydroxy-
1,10-
dimethoxy-
9-
oxobenzo(a)heptalen-
7-
yl)-
, (S)
Colchicine/*analogs & derivatives.
Eur J Clin Invest 1992 Sep;22(9):630-4
3-
chloroacetyl-
3-
demethylthiocolchicine
148731-66-2
Colchicine/*analogs & derivatives.
Biochem Biophys Res Commun 1992 Sep 30;187(3):1350-8
2-
chloroacetyl-
2-
demethylthiocolchicine
148731-67-3
Colchicine/*analogs & derivatives.
Biochem Biophys Res Commun 1992 Sep 30;187(3):1350-8
N-
acetoacetyl-
N-
deacetylcolchicine
88437-23-4
Colchicine/*analogs & derivatives.
J Nat Prod 1990;53(4):1021
2-
demethylspeciosine
111509-13-8
Colchicine/*analogs & derivatives.
J Nat Prod 1990;53(4):1021
N-
acetylcolchinol O-
methyl ether
65967-01-3
Colchicine/*analogs & derivatives.
J Biol Chem 1990;265(18):10255
(2-
nitro-
4-
azidophenyl)deacetylcolchicine
111348-67-5
*Azides
Colchicine/*analogs & derivatives.
Biochemistry 1989;28(21):8515
isocolchicine
30771-10-9
*Colchicine
Isomerism.
J Biol Chem 1989;264(12):6682
cornigerine
6877-25-4
Colchicine/*analogs & derivatives.
Biochem Pharmacol 1988;37(12):2445
6'-
(4'-
azido-
2'-
nitrophenylamino)hexanoyldeacetylcolchicine
98987-40-7
*Azides
Colchicine/*analogs & derivatives.
J Biol Chem 1985;260(25):13794
3-
demethylthiocolchicine
87424-25-7
Colchicine/*analogs & derivatives.
J Med Chem 1985;28(9):1204
2-
demethylthiocolchicine
87424-26-8
Colchicine/*analogs & derivatives.
J Med Chem 1985;28(9):1204
colchifoline
74515-40-5
Colchicine/*analogs & derivatives
Spin Labels.
J Med Chem 1984;27(12):1729
4-
(hydroxymethyl)colchicine
3986-03-6
Colchicine/*analogs & derivatives
Spin Labels.
J Med Chem 1984;27(12):1729
allocolchicine
641-28-1
Colchicine/*analogs & derivatives
Spin Labels.
Acta Chem Scand (B) 1981;35(10):677
desacetamidocolchicine
1420-08-2
Colchicine/*analogs & derivatives.
J Biol Chem 1981;256(12):6241
N-
methylcolchiceinamide
63917-71-5
Colchicine/*analogs & derivatives.
Antimicrob Agents Chemother 1981;19(3):465
colchicine amide
0
Colchicine/*analogs & derivatives.
Chin Med J 1980;93(4):227
N,N-
dimethylcolchiceinamide
2731-13-7 Acetamide, N-
(10-
(dimethylamino)-
5,6,7,9-
tetrahydro-
1,2,3-
trimethoxy-
9-
oxobenzo(a)heptalen-
7-
yl)-
, (S)
Colchicine/*analogs & derivatives.
J Chromatogr 1981;219(2):321
colchicenamide
3123-89-5
Colchicine/*analogs & derivatives.
J Chromatogr 1981;219(2):321
N-
acetylcolchinol
38838-26-5
Colchicine/*analogs & derivatives.
Biochem Biophys Res Commun 83(2):472;1978
bromocolchicine
26195-69-7 Acetamide, 2-
bromo-
N-
(5,6,7,9-
tetrahydro-
1,2,3,10-
tetramethoxy-
9-
oxobenzo(a)heptalen-
7-
yl)-
, (S)
Colchicine/*analogs & derivatives.
Arch Int Physiol Biochim 86(1):212;1978
fluorescein colchicine
66091-34-7 Thiourea, N-
(3',6'-
dihydroxy-
3-
oxospiro(isobenzofuran-
1(3H),9'-
(9H)xanthen)-
5-
yl)-
N'-
(5,6,7,9-
tetrahydro-
1,2,3,10-
tetramethoxy-
9-
oxobenzo(a)heptalen-
7-
yl)
*Fluoresceins
Colchicine/*analogs & derivatives.
J Cell Biol 76(3):619;1978
demethylisothiocolchicine
0
Colchicine/*analogs & derivatives.
Biochem Biophys Res Comm 76(4):1293;1977
thiocholchicine
2730-71-4
Colchicine/*analogs & derivatives.
Cancer Treat Rep 61(2):259;1977
colchicoside
477-29-2
Colchicine/*analogs & derivatives.
J Chromatogr 131:444;1977
colchiceineamide-
L-
ephedrine phosphate
76109-92-7 Benzo(a)heptalen-
9(5H)-
one, 6,7-
dihydro-
1,2,3,10-
tetramethoxy-
7-
(methyl(1-
methyl-
2-
phenyl-
2-
(phosphonooxy)ethyl)amino)-
, disodium salt, (7S-
(7R*(1R*,2S*)))
Colchicine/*analogs & derivatives
Ephedrine/*analogs & derivatives.
Cancer Treat Rep 61(2):259;1977
colchiceine
477-27-0 O-
demethylcolchicine
Colchicine/*analogs & derivatives.
Acta Physiol Scand 1979;107(3):233; Experientia 1979;35(12):1572; Hoppe Seylers Z Physiol Chem 357(4):567;1976; Hoppe Seylers Z Physiol Chem 358:915;1977
trimethylcolchicinic acid
3482-37-9 (S)-
7-
amino-
6,7-
dihydro-
10-
hydroxy-
1,2,3-
trimethoxybenzo(a)heptalen-
9(5H)-
one
Colchicine/*analogs & derivatives.
Eur J Biochem 50(3):563;1975
3-
desmethylcolchicine
7336-33-6
Colchicine/*analogs & derivatives.
J Natural Prod 36(3):338;1973
chlorcolchicine
26279-89-0
Colchicine/*analogs & derivatives.
Schweiz Med Wochenschr 104(8):265;1974
thiocolchicoside
602-41-5
Colchicine/*analogs & derivatives.
Chir Dent France 48(50):51;1978; Gynecol Prat 23(4):197;1972
trimethylcolchicinic acid methyl ether
3476-50-4 (S)-
7-
amino-
6,7-
dihydro-
1,2,3,10-
tetramethoxybenzo(a)heptalen-
9(5H)-
one
Colchicine/*analogs & derivatives.
Cancer Chemother Rep 56(2):263;1972; Oncology 1980;37(1):62; Oncology 3(4):151;1976
androcymbine
2115-98-2
Colchicine/*analogs & derivatives.
J Chem Soc (Org) 14(0):1736;1972