encyclopedia of medical concepts
ψ
ψ
ψ
PPAR alpha
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Definition
: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
Other names
PPARalpha; Peroxisome Proliferator Activated Receptor alpha; Peroxisome Proliferator-
Activated Receptor alpha
Substance
CAS Registry & name
Categories
Source
Drugs
*
(S)-
2-
(2,4-
hexadienoyl)-
7-
(2-
(5-
methyl-
2-
phenyloxazol-
4-
yl)ethoxy)-
1,2,3,4-
tetrahydroisoquinoline-
3-
carboxylic acid
0
*Tetrahydroisoquinolines
PPAR alpha/agonists
PPAR gamma/agonists.
Chem Pharm Bull (Tokyo). 2011;59(7):876-9
2-
(((4-
methoxyphenoxy)carbonyl)(1-
(4-
(2-
(5-
methyl-
2-
phenyloxazol-
4-
yl)ethoxy)phenyl)ethyl)amino)acetic acid
0
*Oxazoles
Glycine/*analogs & derivatives
PPAR alpha/agonists
PPAR gamma/agonists.
Drug Metab Dispos 2011 Feb;39(2):228-38
CG 301269
0
*Oxazoles
*Thiazolidines
PPAR alpha/agonists
PPAR gamma/agonists.
Diabetes 2011 Feb;60(2):496-506
1-
(4-
(2-
(5-
methyl-
2-
p-
tolyloxazol-
4-
yl)ethoxy)benzyl)piperidine-
2-
carboxylic acid
0
*Oxazoles
*Pipecolic Acids
PPAR alpha/agonists
PPAR gamma/agonists.
Mol Pharmacol 2010 Nov;78(5):877-85
3-
(3-
(1-
carboxy-
1-
methylethoxy)phenyl)piperidine-
1-
carboxylic acid 4-
trifluoromethylbenzyl ester
0
*Piperidines
*Propionic Acids
PPAR alpha/agonists.
J Pharmacol Exp Ther 2010 Jun;333(3):844-53
2-
((3-
((2-
(4-
chlorophenyl)-
5-
methyloxazol-
4-
yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid
0
*Oxazoles
Glycine/*analogs & derivatives
PPAR alpha/agonists.
J Med Chem 2010 Apr 8;53(7):2854-64
lobeglitazone
0
*Pyrimidines
*Thiazolidinediones
PPAR alpha/agonists
PPAR gamma/agonists.
J Pharm Biomed Anal 2009 Dec 5;50(5):872-7
2-
methyl-
6-
(3-
(2-
phenyloxazol-
4-
ylmethoxy)propoxymethyl)benzoic acid
0
*Oxazoles
*Benzoic Acids
PPAR alpha/agonists.
Acta Pharmacol Sin 2009 Jul;30(7):935-46
2-
(4-
(2-
Fluoro-
benzenesulphonyl)-
piperazin-
1-
yl)-
3-
(4-
(2-
(5-
methyl-
2-
phenyl-
oxazol-
4-
yl)-
ethoxy)phenyl)propionic acid
0
*Phenylpropionates
*Sulfonamides
PPAR alpha/agonists
PPAR gamma/agonists.
Br J Pharmacol 2009 Jul;157(5):724-35
2-
methyl-
2-
((1-
(3-
phenyl-
7-
propylbenzo(d)isoxazol-
6-
yl)oxy)propyl)-
1H-
4-
indolyloxypropanoic acid
0
*Indoles
*Propionic Acids
DNA Topoisomerases, Type II/antagonists & inhibitors
PPAR alpha/agonists
PPAR gamma/agonists.
Anticancer Drugs 2008 Feb;19(2):151-8
methyl 7-
(2-
(5-
methyl-
2-
phenyloxazol-
4-
yl)ethoxy)coumarin-
7-
carboxylate
0
*Coumarins
*Oxazoles
PPAR alpha/agonists
PPAR gamma/agonists.
Bioorg Med Chem Lett 2003 Oct 20;13(20):3437-40
2-
methyl-
2-
(4-
(((4-
methyl-
2-
(4-
trifluoromethylphenyl)-
thiazol-
5-
ylcarbonyl)amino)methyl)phenoxy)propionic acid
0
*Propionic Acids
*Thiazoles
PPAR alpha/agonists.
J Med Chem 2007 Feb 22;50(4):685-95
naveglitazar
0
*Phenylpropionates
PPAR alpha/agonists
PPAR gamma/agonists.
Drug Metab Dispos 2007 Jan;35(1):51-61
N-
octadecyl-
N'-
propylsulfamide
0
*Sulfonamides
PPAR alpha/agonists.
J Med Chem 2007 Jan 25;50(2):389-93
3-
(4-
(2-
(5-
methyl-
2-
phenyloxazol-
4-
yl)ethoxy)phenyl)-
2-
(2-
(2-
nitrophenoxy)acetylamino)propionic acid
0
*Oxazoles
Tyrosine/*analogs & derivatives
PPAR alpha/agonists
PPAR gamma/agonists.
Biotechnol Lett 2006 Jun;28(12):863-8
2-
ethyl-
5-
(3-
(2-
chloro-
4-
(trifluoromethoxy)phenoxy)propoxy)-
2,3-
dihydro-
1-
benzofuran-
2-
carboxylic acid
0
*Benzofurans
PPAR alpha/agonists.
J Med Chem 2005 Aug 25;48(17):5589-99
2-
(4-
chlorophenoxy)-
3-
phenylpropanoic acid
0
*Phenylpropionates
PPAR alpha/agonists
PPAR gamma/agonists.
J Med Chem 2005 Aug 25;48(17):5509-19
2-
ethoxy-
3-
(4-
((4-
(methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid
0
*Alkanesulfonates
*Phenylpropionates
PPAR alpha/agonists
PPAR gamma/agonists.
Drug Metab Dispos 2004 Sep;32(9):923-9
2-
((5,7-
dipropyl-
3-
trifluoromethyl)benzisoxazol-
6-
yloxy)-
2-
methylpropionic acid
0
*Isoxazoles
*Propionic Acids
PPAR alpha/agonists
PPAR gamma/agonists.
J Med Chem 2005 Apr 7;48(7):2262-5
muraglitazar
0 2-
((4-
methoxyphenoxy)carbonyl-
((4-
(2-
(5-
methyl-
2-
phenyl-
1,3-
oxazol-
4-
yl)ethoxy)phenyl)methyl)amino)acetic acid
*Oxazoles
Glycine/*analogs & derivatives
Phenoxybenzamine
PPAR alpha/agonists
PPAR gamma/agonists.
J Med Chem 2005 Mar 24;48(6):2148-50
L 663536
118414-82-7 1H-
Indole-
2-
propanoic acid, 1-
((4-
chlorophenyl)methyl)-
3-
((1,1-
dimethylethyl)thio)-
alpha,alpha-
dimethyl-
5-
(1-
methylethyl)
*Indoles
PPAR alpha/antagonists & inhibitors.
Pharma Action
Lipoxygenase Inhibitors
Can J Physiol Pharmacol 1989;67(5):456