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DNA Topoisomerase IV

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Definition: A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.      Other names Topoisomerase IV, DNA; parE Gene Product, Topo IV; parE Gene Product; parC Gene Product, Topo IV; parC Gene Product; Topoisomerase IV Subunit B; Topoisomerase IV Subunit A; Topoisomerase IV; Topo IV; parE Protein; parC Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(3',4'-dihydroxyphenyl)-5,7-dihydroxy-3-(2'',6''-di-O-(3'''-(4-fluorophenylpropanoyl)))galactosyl-4H-chromen-4-one  0   *Galactosides Quercetin/*analogs & derivatives DNA Gyrase/antagonists & inhibitors DNA Topoisomerase IV/antagonists & inhibitors. J Med Chem 2011 Jun 9;54(11):3686-703
7-(3-(1-aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione  0   *Pyrrolidines *Quinazolinones DNA Gyrase/antagonists & inhibitors DNA Topoisomerase IV/antagonists & inhibitors. Antimicrob Agents Chemother 2007 Apr;51(4):1191-201
3-amino-7-(3-(1-aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione  0   *Pyrrolidines *Quinazolinones DNA Gyrase/antagonists & inhibitors DNA Topoisomerase IV/antagonists & inhibitors. Antimicrob Agents Chemother 2007 Apr;51(4):1191-201

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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