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Histone Deacetylase Inhibitors
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Definition
: Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.
Other names
Inhibitors, Histone Deacetylase; Inhibitors, HDAC; Inhibitor, Histone Deacetylase; Deacetylase Inhibitors, Histone; Deacetylase Inhibitor, Histone; Histone Deacetylase Inhibitor; HDAC Inhibitors
Substances having this pharmacologic action:
trichostatin A
;
vorinostat
;
scriptaid
;
N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide
;
apicidin
Substance
CAS Registry & name
Categories
Source
Drugs
*
5-
(6-
dimethylamino-
2-
methyl-
3-
oxo-
2,3-
dihydro-
benzofuran-
2-
yl)-
4-
methyl-
penta-
2,4-
dienoic acid hydroxamide
0
*Benzofurans
Histone Deacetylase Inhibitors.
Curr Cancer Drug Targets. 2011 Oct;11(8):919-28
N1-
4-
((biphenylsulphonyl)amino)phenyl-
2-
amino-
3-
phenyl-
propionamide
0
*Biphenyl Compounds
*Phenylpropionates
Antineoplastic Agents
Histone Deacetylase Inhibitors.
Yao Xue Xue Bao. 2010 Jun;45(6):735-41
kendine 92
0
*Pyrroles
Histone Deacetylase Inhibitors.
Epigenetics. 2011 Oct 1;6(10):1228-35
N8-
hydroxy-
2-
(1H-
indole-
2-
carboxamido)-
N1-
(quinolin-
8-
yl)octanediamide
0
*Aminoquinolines
*Hydroxamic Acids
Histone Deacetylase Inhibitors.
J Periodontal Res. 2011 Dec;46(6):697-703.
6-
(3-
hydroxy-
3-
methylbutyl)-
2'-
(7-
hydroxy-
3,7-
dimethyloct-
3-
enyl)-
3',4',7-
trimethoxyflavanone
0
*Monoterpenes
*Flavanones
Histone Deacetylase Inhibitors.
J Ethnopharmacol. 2011 Jun 14;136(1):156-67.
6-
(4-
chlorophenylsulfanyl)-
2,4-
hexadienoic acid hydroxyamide
0
*Hydroxamic Acids
*Sulfides
Histone Deacetylase Inhibitors.
Apoptosis. 2011 Sep;16(9):914-23.
refrofractamide A
0
*Amides
*Benzodioxoles
Histone Deacetylase Inhibitors.
Bioorg Med Chem Lett. 2011 Aug 15;21(16):4844-6.
2-
(2-
(3,3-
dimethylbutanamido)-
3-
methylpentanoyl)-
7-
(2-
(hydroxyamino)-
2-
oxoethoxy)-
N-
(4-
methoxyphenyl)-
1,2,3,4-
tetrahydroisoquinoline-
3-
carboxamide
0
*Hydroxamic Acids
*Isoquinolines
Histone Deacetylase Inhibitors.
J Med Chem 2011 Aug 11;54(15):5532-9
N-
hydroxy-
3-
(4-
((2-
(2-
methylpyrazolo(1,5-
a)pyridin-
3-
yl)ethylamino)methyl)phenyl)acrylamide
0
*Acrylamides
*Hydroxamic Acids
Histone Deacetylase Inhibitors.
J Med Chem 2011 Jul 14;54(13):4752-72
N-
hydroxy-
3-
(4-
(((2-
(2-
(1-
hydroxy-
1-
methylethyl)-
1H-
indol-
3-
yl)ethyl)isopropylamino)methyl)phenyl)acrylamide
0
*Acrylamides
*Hydroxamic Acids
Histone Deacetylase Inhibitors.
J Med Chem 2011 Jul 14;54(13):4752-72
octanedioic acid (1-
(3-
azido-
5-
azidomethylbenzyl)-
1H-
pyrazol-
4-
yl)amide hydroxyamide
0
*Azides
*Hydroxamic Acids
Histone Deacetylase Inhibitors.
J Med Chem 2011 Jul 14;54(13):4350-64
N-
hydroxy-
6-
(((adamantan-
1-
ylamino)carbonyl)amino)hexamide
0
*Hydroxamic Acids
Adamantane/*analogs & derivatives
Histone Deacetylase Inhibitors.
Int J Radiat Oncol Biol Phys 2011 Apr 1;79(5):1541-8
3-
(2-
(4-
quinolin-
3-
yl)benzyl-
1-
oxoisoindolin-
6-
yl)-
N-
hydroxy-
acrylamide
0
*Hydroxamic Acids
*Isoindoles
Histone Deacetylase Inhibitors.
PLoS One 2010;5(11):e13834
3-
(2-
(4-
pyridin-
4-
yl)benzyl-
1-
oxoisoindolin-
6-
yl)-
N-
hydroxyacrylamide
0
*Hydroxamic Acids
*Isoindoles
Histone Deacetylase Inhibitors.
PLoS One 2010;5(11):e13834
SB939 compound
0
*Benzimidazoles
Histone Deacetylase Inhibitors.
Br J Cancer. 2011 Mar 1;104(5):756-62
4-
(2,2-
dimethyl-
4-
phenylbutyrylamino)-
N-
hydroxybenzamide
0
*Benzamides
*Hydroxamic Acids
Histone Deacetylase Inhibitors.
PLoS One 2010;5(9):e12417
Ky-
2 cyclic peptide
0
*Peptides, Cyclic
Histone Deacetylase Inhibitors.
Bioorg Med Chem 2004 Nov 15;12(22):5777-84
2-
(6-
(((6-
fluoroquinolin-
2-
yl)methyl)amino)bicyclo(3.1.0)hex-
3-
yl)-
N-
hydroxypyrimidine-
5-
carboxamide
0
*Pyrimidines
*Azabicyclo Compounds
Histone Deacetylase Inhibitors.
J Med Chem 2010 Dec 23;53(24):8663-78
kendine 91
0
*Hydroxamic Acids
*Pyrroles
Histone Deacetylase Inhibitors.
Cancer Chemother Pharmacol 2009 Jun;64(1):153-9
N-
(2-
aminophenyl)-
4-
(N-
(pyridin-
3-
ylmethoxycarbonyl)aminomethyl)benzamide
0
*Benzamides
*Pyridines
Histone Deacetylase Inhibitors.
Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4592-7