encyclopedia of medical concepts
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trichostatin A

under Hydroxamic Acids
More information in Books or onNLM PubMed
More on Hydroxamic Acids Definition: A class of weak acids with the general formula R-CONHOH.      Other names Acids, Hydroxamic; Acid, Hydroxamic; Hydroxamic Acid
SubstanceCAS Registry & nameCategoriesSourceDrugs*
trichostatin A [ A 300,TSA antibioitc,tricostatin A,trychostatin A ]
  chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein 		58880-19-6 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide  *Hydroxamic Acids
Pharma Action Antifungal Agents; Protein Synthesis Inhibitors; Histone Deacetylase Inhibitors 		J Antibiot (Tokyo) 29(1):1;1976; J Antibiot (Tokyo) 31(10):939;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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