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Procollagen-Proline Dioxygenase

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Definition: A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.     
See Also Protein Disulfide-Isomerases 		Other names Protocollagen Prolyl Hydroxylase; Proline,2-Oxoglutarate 4-Dioxygenase; Proline Hydroxylase; Prolyl Hydroxylase, Protocollagen; Prolyl Hydroxylase, Peptidyl; Prolyl 4-Hydroxylase, Procollagen; Prolyl 4 Hydroxylase; Proline,2 Oxoglutarate 4 Dioxygenase; Procollagen Prolyl 4 Hydroxylase; Procollagen Proline Dioxygenase; Hydroxylase, Protocollagen Prolyl; Hydroxylase, Prolyl; Hydroxylase, Proline; Hydroxylase, Peptidyl Prolyl; Dioxygenase, Procollagen-Proline; 4-Hydroxylase, Prolyl; 4-Hydroxylase, Procollagen Prolyl; 4-Dioxygenase, Proline,2-Oxoglutarate; Prolyl Hydroxylase; Prolyl 4-Hydroxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LEPREL1 protein, human  EC 1.14.11.-   *Procollagen-Proline Dioxygenase. Am J Hum Genet 2011 Sep 9;89(3):438-45
1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid  0   *Benzimidazoles *Pyrazoles Procollagen-Proline Dioxygenase/antagonists & inhibitors. Mol Pharmacol 2011 Jun;79(6):910-20
FG 0041  0   *Phenanthrolines Procollagen-Proline Dioxygenase/antagonists & inhibitors. Biochem Biophys Res Commun 2008 Dec 12;377(2):400-6
2-amino-4-methylsulfanylbutyric acid 4-methoxy-6-(4-methoxybenzylamino)-2,2-dimethylchroman-3-yl ester  0   *Aminobutyric Acids *Benzopyrans Procollagen-Proline Dioxygenase. Br J Pharmacol 2008 May;154(1):114-25
P4hb protein, rat  EC 5.3.4.1   *Procollagen-Proline Dioxygenase *Protein Disulfide-Isomerases.
P4hb protein, mouse  EC 5.3.4.1   *Procollagen-Proline Dioxygenase *Protein Disulfide-Isomerases.
P4HB protein, human  EC 5.3.4.1   *Procollagen-Proline Dioxygenase *Protein Disulfide-Isomerases.
PHD3 protein, mouse  EC 1.14.11.2   *Procollagen-Proline Dioxygenase. Gene 2001 Sep 5;275(1):125-32
PHD1 protein, mouse  EC 1.14.11.2   *Procollagen-Proline Dioxygenase. Gene 2001 Sep 5;275(1):125-32
PHD2 protein, rat  EC 1.14.11.2   *Procollagen-Proline Dioxygenase. J Mol Cell Cardiol 2006 Jul;41(1):68-77
P4HA1 protein, human  EC 1.14.11.2   *Procollagen-Proline Dioxygenase. J Biol Chem 2006 Apr 21;281(16):10849-55
Hif prolyl hydroxylase, Drosophila  EC 1.14.11.2   *Procollagen-Proline Dioxygenase. Cell Cycle 2004 May;3(5):558-60
EGLN1 protein, human  EC 1.14.11.2   *Procollagen-Proline Dioxygenase.
Egln1 protein, mouse  EC 1.14.11.2   *Procollagen-Proline Dioxygenase.
P4HA3 protein, human  EC 1.14.11.2   *Procollagen-Proline Dioxygenase. Circulation 2003 Aug 5;108(5):508-11
Phy-1 protein, Brugia malayi  0   *Procollagen-Proline Dioxygenase. J Biol Chem 2003 Jan 24;278(4):2554-62
(2,2'-bipyridine)-5,5'-dicarboxylic acid  1802-30-8 (2,2'-Bipyridine)-5,5'-dicarboxylic acid  *Nicotinic Acids 2,2'-Dipyridyl/*analogs & derivatives Procollagen-Proline Dioxygenase/antagonists & inhibitors. J Med Chem 1993 Nov 26;36(24):3853-8
(2,2'-bipyridine)-5-carboxylic acid  1970-80-5 (2,2'-Bipyridine)-5-carboxylic acid  *Nicotinic Acids 2,2'-Dipyridyl/*analogs & derivatives Procollagen-Proline Dioxygenase/antagonists & inhibitors. J Med Chem 1993 Nov 26;36(24):3853-8
lufironil  128075-79-6 2,4-Pyridinedicarboxamide, N,N'-bis(2-methoxyethyl)  *Pyridines Procollagen-Proline Dioxygenase/antagonists & inhibitors. J Hepatol 1991;13 Suppl 3:S26-34
diethyl 2,4-pyridinedicarboxylic acid  41438-38-4   *Pyridines Procollagen-Proline Dioxygenase/antagonists & inhibitors. Biochem J 1991;275(Pt 2):469
ribosyl-ribosyladenine  28269-89-8   *Mixed Function Oxygenases Adenosine/*analogs & derivatives Procollagen-Proline Dioxygenase/antagonists & inhibitors. J Biol Chem 1989;264(14):7850
fibrostatin C  91776-47-5 L-Cysteine, N-acetyl-S-((5,8-dihydro-1-hydroxy-3,6-dimethoxy-5,8-dioxo-2-naphthalenyl)methyl)  *Naphthoquinones Cysteine/*analogs & derivatives Procollagen-Proline Dioxygenase/antagonists & inhibitors. J Antibiot (Tokyo) 1988;41(11):1668
coumalic acid  500-05-0   *Pyrones Procollagen-Proline Dioxygenase/antagonists & inhibitors. Biochem J 1987;242(1):163
5-azidopyridine-2-carboxylic acid  108885-79-6   *Azides *Picolinic Acids Procollagen-Proline Dioxygenase/antagonists & inhibitors. Biochim Biophys Acta 1987;912(1):151
2,7,8-trihydroxyanthraquinone  82-29-1   *Anthraquinones Procollagen-Proline Dioxygenase/antagonists & inhibitors. Biochem J 1986;239(2):311
vineomycin A1  78164-00-8 Benz(a)anthracene-1,7,12(2H)-trione, 9-(2,6-dideoxy-4-O-(5-((5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)-beta-arabino-hexopyranosyl)-3-((5-((5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl)oxy)tetrahydro-6-methyl-2H-pyran-2-y  *Anthraquinones Procollagen-Proline Dioxygenase/antagonists & inhibitors. J Antibiot (Tokyo) 1981;34(10):1355; J Antibiot (Tokyo) 1981;34(11):1517
proline, 2-oxoglutarate 3-dioxygenase  EC 1.14.11.7   *Procollagen-Proline Dioxygenase. Biochim Biophys Acta 1981;674(2):238
dipicolinic acid  499-83-2   *Picolinic Acids Procollagen-Proline Dioxygenase/antagonists & inhibitors.
Pharma Action Chelating Agents ; Enzyme Inhibitors 		Am J Clin Pathol 1980;73(1):121; J Biochem (Tokyo) 83(2):507;1978

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