encyclopedia of medical concepts
ψ 
ψ 
ψ 

2-Pyridinylmethylsulfinylbenzimidazoles

More information in Books or onNLM PubMed
Definition: Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.     
Examples Omeprazole 		Other names Sulfoxides, Benzimidazole Methylpyridine; Sulfoxides, 2-Methylpyridine 2-Benzimidazole; Methylpyridine Sulfoxides, Benzimidazole; 2-Benzimidazole Sulfoxides, 2-Methylpyridine; 2 Pyridinylmethylsulfinylbenzimidazoles; 2 Pyridinylmethylsulfinyl 2 Benzimidazoles; 2 Methylpyridine 2 Benzimidazole Sulfoxides; Benzimidazole Methylpyridine Sulfoxides; 2-Pyridinylmethylsulfinyl-2-Benzimidazoles; 2-Methylpyridine 2-Benzimidazole Sulfoxides
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
rabeprazole-thioether  0   *Sulfides *2-Pyridinylmethylsulfinylbenzimidazoles. Eur J Clin Pharmacol. 2006 Feb;62(2):113-7
5-hydroxylansoprazole  0   *2-Pyridinylmethylsulfinylbenzimidazoles. Eur J Clin Pharmacol. 2004 Nov;60(9):623-8
pantoprazole  102625-70-7 1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)  *2-Pyridinylmethylsulfinylbenzimidazoles H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors.
Pharma Action Anti-Ulcer Agents ; Proton Pump Inhibitors 		Biochem Pharmacol 1990;39(11):1799PROTONIX; PANTOPRAZOLE SODIUM; PROTONIX IV; PANTOPRAZOLE
rabeprazole  117976-90-6   *2-Pyridinylmethylsulfinylbenzimidazoles Adenosine Triphosphatases/antagonists & inhibitors Proton-Translocating ATPases/antagonists & inhibitors Stereoisomerism.
Pharma Action Anti-Ulcer Agents ; Enzyme Inhibitors 		Biochem Pharmacol 1990;39(4):661ACIPHEX; RABEPRAZOLE SODIUM; RABEPRAZOLE
AG 1812  114559-57-8   *2-Pyridinylmethylsulfinylbenzimidazoles. J Pharmacol Exp Ther 1989;248(2):799
lansoprazole  103577-45-3   *2-Pyridinylmethylsulfinylbenzimidazoles Proton Pumps/antagonists & inhibitors H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors.
Pharma Action Anti-Infective Agents ; Anti-Ulcer Agents ; Enzyme Inhibitors 		J Pharmacol Exp Ther 1989;248(2):799PREVACID; LANSOPRAZOLE; PREVACID NAPRAPAC 250 (COPACKAGED); PREVACID NAPRAPAC 375 (COPACKAGED); PREVACID IV; DEXILANT; PREVACID 24 HR; PREVACID NAPRAPAC 500 (COPACKAGED)
5-hydroxymethylomeprazole  92340-57-3   *2-Pyridinylmethylsulfinylbenzimidazoles. Clin Pharmacol Ther 1986;40(3):344
B 823-10  86604-68-4   *2-Pyridinylmethylsulfinylbenzimidazoles H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Br J Pharmacol 1986;88(2):389
B 823-08  86604-69-5   *2-Pyridinylmethylsulfinylbenzimidazoles. Br J Pharmacol 1986;88(2):389
2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole  100924-68-3 Benzenamine, 2-((1H-benzimidazol-2-ylsulfinyl)methyl)-N,N-dimethyl  *2-Pyridinylmethylsulfinylbenzimidazoles Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Jpn J Pharmacol 1986;40(2):239
picoprazole  78090-11-6 1H-Benzimidazole-5-carboxylic acid, 6-methyl-2-(((3-methyl-2-pyridinyl)methyl)sulfinyl)-, methyl ester  *2-Pyridinylmethylsulfinylbenzimidazoles. Nature 1981;290(5802):152

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy