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Sodium-Potassium-Exchanging ATPase

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Definition: An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.  DF: NA K ATPASE    Other names Sodium-Potassium Pump; Sodium, Potassium Adenosinetriphosphatase; Sodium, Potassium ATPase; Sodium Pump; Potassium Pump; Na(+)-K(+)-Transporting ATPase; Na(+)-K(+)-Exchanging ATPase; Adenosinetriphosphatase, Sodium, Potassium; ATPase, Sodium, Potassium; Sodium Potassium Pump; Sodium Potassium Exchanging ATPase; Pump, Sodium-Potassium; Pump, Sodium; Pump, Potassium; Adenosinetriphosphatase Sodium, Potassium; ATPase, Sodium-Potassium-Exchanging; ATPase Sodium, Potassium; Sodium, Potassium Adenosine Triphosphatase; Na(+) K(+)-Transporting ATPase; Adenosine Triphosphatase, Sodium, Potassium
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PpENA1 protein, Physcomitrella patens  EC 3.6.3.9   *Sodium-Potassium-Exchanging ATPase. Biochim Biophys Acta. 2011 Jun;1808(6):1483-92
ATP1A1 protein, C elegans  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase *Caenorhabditis elegans Proteins. PLoS One. 2010;5(4) (dup#6):e10368
emicymarin  0   *Saponins Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Steroids 2010 Dec 12;75(13-14):1137-45
sodium potassium ATPase alpha3 subunit, human  EC 3.6.3.9   *Sodium-Potassium-Exchanging ATPase Protein Subunits. J Biol Chem 2010 Aug 20;285(34):26245-54
Nrv3 protein, Drosophila  EC 3.6.3.9   *Sodium-Potassium-Exchanging ATPase *Drosophila Proteins. Development 2007 Jan;134(1):147-55
NaKtide  0   *Sodium-Potassium-Exchanging ATPase *Peptide Fragments. J Biol Chem 2009 Jul 31;284(31):21066-76
Atp1b3 protein, mouse  EC 3.6.3.9   *Sodium-Potassium-Exchanging ATPase Protein Subunits. Pain. 2009 Aug;144(3):294-302
4,7-diacetoxy-14-hydroxydolast-1(15),8-diene  0   *Diterpenes Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Phytother Res. 2009 Jul;23(7):943-7
4-acetoxy-9,14-dihydroxydolast-1(15),7-diene  0   *Diterpenes Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Phytother Res. 2009 Jul;23(7):943-7
6'-hydroxy-16alpha-acetoxycalactin  0   *Cardenolides *Glycosides Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Nat Prod 2009 Jun;72(6):1087-91
6'-hydroxycalactin  0   *Cardenolides *Glycosides Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Nat Prod 2009 Jun;72(6):1087-91
Atp1a3 protein, rat  EC 3.6.3.9   *Sodium-Potassium-Exchanging ATPase. J Assoc Res Otolaryngol 2009 Mar;10(1):37-49
Atp1a3 protein, mouse  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase. J Physiol 2007 Dec 1;585(Pt 2):491-505
8-methoxy-3,9-dihydroxycoumestan  0   *Benzofurans *Coumarins Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Life Sci 2007 Sep 22;81(15):1199-204
Ncx4a protein, zebrafish  EC 3.6.1.37   *Sodium-Potassium-Exchanging ATPase *Zebrafish Proteins Protein Subunits. Development 2007 May;134(10):1921-30
alpha2 protein, Na(+)-K(+)-exchanging ATPase, zebrafish  EC 3.6.1.37   *Sodium-Potassium-Exchanging ATPase *Zebrafish Proteins Protein Subunits. Genome Res 2001 Oct;11(10):1625-31
ATP1B3 protein, human  EC 3.6.1.37   *Sodium-Potassium-Exchanging ATPase Protein Subunits. Mamm Genome 1998 Feb;9(2):136-43
Atp1b1 protein, rat  0   *Sodium-Potassium-Exchanging ATPase.
Atp1b1 protein, mouse  0   *Sodium-Potassium-Exchanging ATPase.
ATP1B1 protein, human  EC 3.6.1.37   *Sodium-Potassium-Exchanging ATPase.
Na K ATPase beta2 subunit, rat  EC 3.6.1.37   *Sodium-Potassium-Exchanging ATPase. Protein Expr Purif 2004 Sep;37(1):47-52
ATP1A1 protein, human  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase.
Atp1a1 protein, rat  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase.
atp1a1 protein, Xenopus  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase *Xenopus Proteins.
Fxyd2 protein, rat  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase.
Fxyd2 protein, mouse  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase.
Atp1a2 protein, rat  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase.
ATP1A2 protein, human  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase.
Atp1a1 protein, mouse  EC 3.6.1.37   *Sodium-Potassium-Exchanging ATPase. J Biol Chem 2004 Dec 24;279(52):54053-61
ATP1A3 protein, human  EC 3.6.1.37   *Sodium-Potassium-Exchanging ATPase. Neuron 2004 Jul 22;43(2):169-75
Atp1a4 protein, rat  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase.
ATP1A4 protein, human  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase Isoenzymes.
ATPalpha protein, Drosophila  EC 3.6.1.37   *Sodium-Potassium-Exchanging ATPase *Drosophila Proteins. J Neurosci 2003 Feb 15;23(4):1276-86
3-((2-aminoethoxy)imino)androstane-6,17-dione  0   Etiocholanolone/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Pharmacol Exp Ther 2002 Nov;303(2):592-600
3-hydroxy-17-(2-((2-(N,N-dimethylamino)ethoxy)imino)ethyl)-14,15-secoandrostan-14-one  0   *Secosteroids Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Med Chem 2001 Nov 8;44(23):3821-30
17-(2-((2-aminoethoxy)imino)ethyl)androstane-3,14-diol  0   *Androstanols Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Med Chem 2001 Nov 8;44(23):3821-30
atp1a1a1 protein, zebrafish  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase *Zebrafish Proteins. Genome Res 2001 Oct;11(10):1625-31
atp1a1b protein, zebrafish  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase *Zebrafish Proteins. Genome Res 2001 Oct;11(10):1625-31
halenaquinol  0   *Benz(a)Anthracenes Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Comp Biochem Physiol C Toxicol Pharmacol 2001 Apr;128(4):531-40
aplysiallene  0   *Furans *Bicyclo Compounds, Heterocyclic Sodium-Potassium-Exchanging ATPase. Biosci Biotechnol Biochem 2001 Feb;65(2):474-6
iantheran B  0   *Benzofurans *Phenols Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Bioorg Med Chem 2001 Jan;9(1):179-83
iantheran A  0   *Benzofurans *Phenols Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Bioorg Med Chem 2001 Jan;9(1):179-83
YcfA protein, Erwinia amylovora  0   *Sodium-Potassium-Exchanging ATPase *Bacterial Proteins. Mol Gen Genet 2000 Oct;264(3):233-40
FXYD2 protein, human  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase. Nat Genet 2000 Nov;26(3):265-6
17-(3-((2-dimethylaminoethoxy)imino)propyl)-5-androstane-3,14-diol  0   *Androstanols Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Med Chem 2000 Jun 15;43(12):2332-49
17-(((4-aminobutoxy)imino)methyl)-5-androstane-3,14-diol  0   *Androstanols Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Med Chem 2000 Jun 15;43(12):2332-49
Atp1a2 protein, mouse  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase. Biochemistry 1999 Nov 9;38(45):14746-51
Atp1a4 protein, mouse  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase. Biochemistry 1999 Nov 9;38(45):14746-51
endobain E  0   Ouabain/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Neuroscience 1999 May;90(2):573-9
6'-O-(4-hydroxycinnamoyl)desglucouzarin  0   *Cardenolides Curcumin/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors Plant Extracts. Biochem Biophys Res Commun 1998 Oct 9;251(1):256-9
epoxyscillirosidin  0   *Cholenes Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Int J Biochem Cell Biol 1997 Aug-Sep;29(8-9):1103-12
1,3-dibromo-2,4,6-tris-(methylisothiouronium)benzene  0   Isothiuronium/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Biol Chem 1997 Oct 3;272(40):24987-93
marinosin  0   *Bufanolides Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1997 Feb;45(2):249-54
2-((2,4-dimethoxybenzyl)sulfinyl)-N-(4-pyridyl)nicotinamide  0   Niacinamide/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Med Chem 1997 Jan 31;40(3):313-21
ptilomycalin A  0   *Guanidines Calcium-Transporting ATPases/antagonists & inhibitors Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Eur J Pharmacol 1996 Aug 22;310(1):95-8
ENA1 protein, S cerevisiae  EC 3.6.3.9   *Sodium-Potassium-Exchanging ATPase *Saccharomyces cerevisiae Proteins. J Biol Chem 1994 Mar 25;269(12):8792-6
4-(diazomethyl)-7-(diethylamino)coumarin  88861-43-2   *Coumarins Diazomethane/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Biol Chem 1994 Mar 4;269(9):6892-9
tylogenin  135247-46-0   *Phenanthrenes *Steroids 4-Butyrolactone/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Gen Pharmacol 1993 Sep;24(5):1107-13
acetyltylophoroside  135247-54-0   *Saponins Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Gen Pharmacol 1993 Sep;24(5):1107-13
sodium-potassium ATPase inhibitory factor  0   *Ouabain Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Proc Natl Acad Sci U S A 1993 Sep 1;90(17):8189-93
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