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Isoenzymes

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Definition: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.  IM general only; coordinate NIM with specific enzyme (IM)    Other names Isozymes; Allozymes; Alloenzymes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PCYT1B protein, human  EC 2.7.7.15   *Choline-Phosphate Cytidylyltransferase Isoenzymes. Clin Chim Acta. 2009 Oct;408(1-2):34-8
3 beta-hydroxysteroid dehydrogenase type II  EC 1.1.1.145   *Progesterone Reductase Isoenzymes.
GPAT4 protein, mouse  EC 2.3.1.15   *Glycerol-3-Phosphate O-Acyltransferase Isoenzymes. J Lipid Res. 2008 Apr;49(4); 823-31
Atp2b2 protein, mouse  EC 3.6.3.8   *Plasma Membrane Calcium-Transporting ATPases Isoenzymes.
Capn3 protein, rat  EC 3.4.22.-   *Calpain *Isoenzymes *Muscle Proteins.
Mat1a protein, mouse  EC 2.5.1.6   *Methionine Adenosyltransferase Isoenzymes. FASEB J 2004 May;18(7):914-6
Prkcq protein, mouse  EC 2.7.1.-   *Isoenzymes *Protein Kinase C Zinc Fingers.
Pkcq protein, rat  EC 2.7.1.-   *Isoenzymes *Protein Kinase C Zinc Fingers.
adenosine deaminase-complexing protein, Oryctolagus cuniculus  EC 3.4.14.5   *Adenosine Deaminase *Glycoproteins Isoenzymes.
ATP1A4 protein, human  EC 3.6.1.-   *Sodium-Potassium-Exchanging ATPase Isoenzymes.
CYP4Z1 protein, human  EC 1.14.14.-   *Cytochrome P-450 Enzyme System Breast Neoplasms Isoenzymes. Cancer Res. 2004 Apr 1;64(7):2357-64
agalsidase beta  EC 3.2.1.-   *alpha-Galactosidase *Isoenzymes. J Biotechnol 2002 May 23;95(3):280-2FABRAZYME
SGMS1 protein, human  EC 2.7.8.-   *Membrane Proteins *Nerve Tissue Proteins *Transferases (Other Substituted Phosphate Groups) Isoenzymes. Biomol Eng 2002 Feb;18(6):263-8; Mol Biol (Mosk). 2003 Mar-Apr;37(2):315-24
topoisomerase III beta  EC 3.1.-   *DNA Topoisomerases, Type I *Isoenzymes. Biochem Biophys Res Commun 2001 Sep 14;287(1):282-7
peptidyl-prolyl cis-trans isomerase b  EC 5.2.1.-   *Peptidylprolyl Isomerase Isoenzymes. J Biomol NMR 2000 Sep;18(1):75-6
glutathione transferase M3-3  EC 2.5.1.18   *Glutathione Transferase Isoenzymes. Neurochem Res 2000 May;25(5):733-6
agalsidase alfa  EC 3.2.1.-   *alpha-Galactosidase Isoenzymes Fabry Disease. Clin Pharmacol Ther 2000 Oct;68(4):456
Akp3 protein, rat  EC 3.1.3.-   *Alkaline Phosphatase *Isoenzymes. Physiol Genomics 2000 Jun 29;3(1):1-8
Alpi protein, rat  EC 3.1.3.-   *Alkaline Phosphatase *Isoenzymes. Physiol Genomics 2000 Jun 29;3(1):1-8
lactate dehydrogenase 4  EC 1.1.1.27   *L-Lactate Dehydrogenase Isoenzymes.
lactate dehydrogenase 3  EC 1.1.1.27   Isoenzymes *L-Lactate Dehydrogenase.
lactate dehydrogenase 2  EC 1.1.1.27   *L-Lactate Dehydrogenase Isoenzymes.
lactate dehydrogenase-K  EC 1.1.1.27   *L-Lactate Dehydrogenase Isoenzymes.
lactate dehydrogenase C4  EC 1.1.1.27.-   *L-Lactate Dehydrogenase Isoenzymes.
lactate dehydrogenase 5  EC 1.1.1.27.-   *L-Lactate Dehydrogenase Isoenzymes.
lactate dehydrogenase 1  EC 1.1.1.27.-   *L-Lactate Dehydrogenase Isoenzymes.
Apl II protein kinase C  EC 2.7.1.-   *Isoenzymes *Protein Kinase C. Learn Mem 1997 Jan-Feb;3(5):389-401
glutathione S-transferase alpha  EC 2.5.1.18   *Glutathione Transferase *Isoenzymes. Jpn J Cancer Res 1999 May;90(5):530-5
8-methoxymethyl-3-isobutyl-1-methylxanthine  0   *Xanthines Isoenzymes/antagonists & inhibitors. Life Sci 1999;64(23):2081-8
NBR-B isoenzyme  EC 2.7.4.-   *Isoenzymes *Nucleoside-Diphosphate Kinase. FEBS Lett 1999 Apr16;449(1):83-7
NBR-A isoenzyme  EC 2.7.4.-   *Isoenzymes *Nucleoside-Diphosphate Kinase. FEBS Lett 1999 Apr 16;449(1):83-7
cytochrome P-450 CYP2A14 (hamster)  0   *Cytochrome P-450 Enzyme System Isoenzymes. Arch Biochem Biophys 1998 Nov 15;359(2):241-8
phorbol 12-pyrenebutyrate 13-(3,3,3-trifloro-2-diazopropioate)  0   *Diazonium Compounds *Phorbols Isoenzymes Protein Kinase C. Bioorg Med Chem 1998 Jul;6(7):1117-26
AMY1.2 protein, Hordeum vulgare  EC 3.2.1.1   *alpha-Amylases *Isoenzymes *Plant Proteins. Structure 1998 May 15;6(5):649-59
SOD-4 protein, C elegans  EC 1.15.1.-   *Isoenzymes *Superoxide Dismutase *Caenorhabditis elegans Proteins. DNA Res 1998 Feb 28;5(1):25-30
protein tyrosine kinase Pyk2-H  EC 2.7.1.-   *Isoenzymes *Protein-Tyrosine Kinases. J Biol Chem 1998 Jun 5;273(23):14301-8
glutathione S-transferase 9.5-2  EC 2.5.1.-   *Glutathione Transferase *Isoenzymes. Arch Biochem Biophys 1998 May 15;353(2):337-48
glutathione S-transferase 9.5-1  EC 2.5.1.-   *Glutathione Transferase *Isoenzymes. Arch Biochem Biophys 1998 May 15;353(2):337-48
smooth muscle short-chain alcohol dehydrogenase  EC 1.1.-   *Alcohol Oxidoreductases *Isoenzymes. J Steroid Biochem Mol Biol 1997 Sep-Oct;63(1-3):115-21
ubiquitin C-terminal hydrolase 8  EC 3.1.2.-   *Isoenzymes *Thiolester Hydrolases. Biochem J 1997 Jul 15;325( Pt 2):325-30
aldehyde dehydrogenase 1  EC 1.2.1.-   *Isoenzymes *Retinal Dehydrogenase. Adv Exp Med Biol 1997;414:19-27
glycogen phosphorylase 2 protein, Dictyostelium discoideum  EC 2.4.1.-   *Phosphorylases DNA-Binding Proteins Isoenzymes. Biochim Biophys Acta 1997 Mar 20;1351(1-2):111-25; Dev Genet. 1993;14(4):313-22; J Biol Chem. 1992 Feb 5;267(4):2294-302
heme oxygenase-2  EC 1.14.99.3   *Heme Oxygenase (Decyclizing) Isoenzymes. Biochim Biophys Acta 1997 Mar 20;1351(1-2):89-104
phosphoglycerate kinase, testis specific  EC 2.7.2.3   *Isoenzymes *Phosphoglycerate Kinase. Dev Genet 1996;19(4):321-32
amadoriase  EC 1.5.3.-   *Amino Acid Oxidoreductases Isoenzymes. J Biol Chem 1996 Dec 20;271(51):32803-9
tartrate-resistant acid phosphatase  EC 3.1.3.-   *Acid Phosphatase *Isoenzymes Tumor Markers, Biological Biological Markers. Blood 1995 May 15;85(10):2839-44
AT-II acetyltransferase  EC 2.3.1.-   *Arylamine N-Acetyltransferase *Isoenzymes. Pharmacogenetics 1994 Apr;4(2):91-100
AT-I acetyltransferase  EC 2.3.1.-   *Arylamine N-Acetyltransferase *Isoenzymes. Pharmacogenetics 1994 Apr;4(2):91-100
N-acetyltransferase 1  EC 2.3.1.5   *Arylamine N-Acetyltransferase *Isoenzymes. Pharmacogenetics 1994 Apr;4(2):82-90
basiliscusfibrase  EC 3.4.24.-   *Metalloendopeptidases Crotalid Venoms Isoenzymes. Thromb Res 1994 May 15;74(4):355-67
CA9 protein, human  EC 4.2.1.1   *Antigens, Neoplasm *Carbonic Anhydrases Antigens, Neoplasm Isoenzymes Tumor Markers, Biological. Am J Pathol 1994 Sep;145(3):598-609
protein kinase C beta  EC 2.7.1.-   *Protein Kinase C Isoenzymes. J Biol Chem 1994 Jul 29;269(30):19578-84
DNA topoisomerase II alpha  EC 5.99.1.3   *Antigens, Neoplasm *DNA Topoisomerases, Type II *DNA-Binding Proteins Isoenzymes. Neurosci Res 1994 Feb;19(1):51-7
protein kinase C gamma  EC 2.7.1.-   *Protein Kinase C Isoenzymes. Neuroreport 1994 Jan 12;5(4):381-4
protein kinase C lambda  EC 2.7.1.37   *Isoenzymes *Protein Kinase C Zebrafish Proteins. J Biol Chem 1994 Apr 29;269(17):12677-83
proteinase D  EC 3.4.21.-   *Isoenzymes *Kallikreins. Endocrinology 1993 Sep;133(3):1051-60
proteinase P  EC 3.4.21.-   *Isoenzymes *Kallikreins. Endocrinology 1993 Sep;133(3):1051-60
protein kinase C eta  EC 2.7.1.-   *Protein Kinase C Isoenzymes. Tohoku J Exp Ther 1992 Oct;168(2):211-22
PCSK6 protein, human  EC 3.4.21.-   *Serine Endopeptidases *Proprotein Convertases Isoenzymes. J Biochem (Tokyo) 1993 Feb;113(2):132-5
beta-ketoacyl-acyl carrier protein synthase I  EC 2.3.1.-   *Isoenzymes *3-Oxoacyl-(Acyl-Carrier-Protein) Synthase. J Biol Chem 1992 Nov 25;267(33):23999-4006
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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