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Nucleoside-Diphosphate Kinase

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Definition: An enzyme that is found in mitochondria and in the soluble cytoplasm of cells. It catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside diphosphate, e.g., UDP, to form ADP and UTP. Many nucleoside diphosphates can act as acceptor, while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC 2.7.4.6.     
Examples NM23 Nucleoside Diphosphate Kinases 		Other names Nucleoside Diphosphate Kinases; Nucleoside Diphosphate Kinase; Kinases, Nucleoside-Diphosphate; Kinases, Deoxynucleoside Diphosphate; Kinase, Nucleoside-Diphosphate; Kinase, GDP; Diphosphokinases, Nucleoside; Diphosphate Kinases, Deoxynucleoside; Nucleoside-Diphosphate Kinases; Nucleoside Diphosphokinases; GDP Kinase; Deoxynucleoside Diphosphate Kinases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NDPK-B protein, human  EC 2.7.4.6.   Nucleoside-Diphosphate Kinase. Proc West Pharmacol Soc. 2008;51(); 30-4
nucleoside-diphosphate kinase 1, Arabidopsis  EC 2.7.4.6.   *Nucleoside-Diphosphate Kinase *Arabidopsis Proteins. Plant Cell Physiol 2003 Oct;44(10);982-9
YNK1 protein, S cerevisiae  EC 2.7.4.6   *Nucleoside-Diphosphate Kinase *Mitochondrial Proteins *Saccharomyces cerevisiae Proteins. Biochem J 2003 Mar 15;370(Pt 3):805-15
nucleoside diphosphate kinase 2  EC 2.7.4.-   *Nucleoside-Diphosphate Kinase. Nature 1999 Oct 7;401(6753):610-3
NBR-B isoenzyme  EC 2.7.4.-   *Isoenzymes *Nucleoside-Diphosphate Kinase. FEBS Lett 1999 Apr16;449(1):83-7
NBR-A isoenzyme  EC 2.7.4.-   *Isoenzymes *Nucleoside-Diphosphate Kinase. FEBS Lett 1999 Apr 16;449(1):83-7
Gip17 protein, Dictyostelium discoideum  EC 2.7.4.6   *Nucleoside-Diphosphate Kinase *Protozoan Proteins. J Natl Cancer Inst 1990;82(14):1199
awd protein, Drosophila  EC 2.7.4.6   *Nucleoside-Diphosphate Kinase *Drosophila Proteins. Nature 1989;342(6246):177
uridine diphosphate kinase  EC 2.7.4.-   *Nucleoside-Diphosphate Kinase. J Neurochem 1981;36(3):1166

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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