Protein-Tyrosine Kinases (definition)

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ψ	Protein-Tyrosine Kinases

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Definition: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.

Other names Tyrosine-Specific Protein Kinase; Tyrosine Protein Kinase; Tyrosine Specific Protein Kinases; Tyrosine Specific Protein Kinase; Protein Tyrosine Kinases; Protein Tyrosine Kinase; Protein Kinases, Tyrosine-Specific; Protein Kinases, Tyrosine; Protein Kinase, Tyrosine-Specific; Kinases, Tyrosine-Specific Protein; Kinases, Tyrosine Protein; Kinases, Protein-Tyrosine; Kinase, Tyrosylprotein; Kinase, Tyrosine-Specific Protein; Kinase, Tyrosine Protein; Kinase, Tyrosine; Kinase, Protein-Tyrosine; Tyrosylprotein Kinase; Tyrosine-Specific Protein Kinases; Tyrosine Protein Kinases

Substance	CAS Registry & name	Categories	Source	Drugs*
HHGV678	0	Piperazines Pyrimidines Protein-Tyrosine Kinases/antagonists & inhibitors.	Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1039-43
Rop16 protein, Toxoplasma gondii	EC 2.7.10.1	Protein-Tyrosine Kinases Protozoan Proteins Virulence Factors.	J Biol Chem 2010 Sep 10;285(37):28731-40
TKM0150	0	Benzodiazepines Pyrazoles Protein-Tyrosine Kinases/antagonists & inhibitors.	Arzneimittelforschung. 2010;60(5):282-5
Dyrk1b protein, zebrafish	EC 2.7.10.1	Protein-Tyrosine Kinases Zebrafish Proteins.	Genesis 2010 Jan;48(1):20-30
CH 331	0	*Quinazolines Protein-Tyrosine Kinases/antagonists & inhibitors.	Int J Pharm 2009 Mar 18;369(1-2):19-23
4-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)benzamide	0	Benzamides Thiazoles Histone Deacetylases/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors.	J Med Chem 2009 Apr 23;52(8):2265-79
N2-(2-aminophenyl)-N5-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)thiophene-2,5-dicarboxamide	0	Pyrimidines Thiophenes Histone Deacetylases/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors.	J Med Chem 2009 Apr 23;52(8):2265-79
N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)terephthalamide	0	Phthalic Acids Pyrimidines Histone Deacetylases/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors.	J Med Chem 2009 Apr 23;52(8):2265-79
Jak2a protein, zebrafish	EC 2.7.1.112	Protein-Tyrosine Kinases Zebrafish Proteins.	Biochem Biophys Res Commun 2009 Jan 16;378(3):629-33
Scd-2 protein, C elegans	EC 2.7.1.112	Protein-Tyrosine Kinases Caenorhabditis elegans Proteins.	Curr Biol 2008 Jul 5;18(15):1101-9
WEE1 protein, Xenopus	EC 2.7.1.-	Protein-Tyrosine Kinases Cell Cycle Proteins *Xenopus Proteins.	Curr Biol 2008 Mar 25;18(6):R244-5
N-(4-(1-methylethyl)phenyl)-4-(2-(3-pyridinyl)ethyl)-1-phthalazinamine	0	Aniline Compounds Phthalazines Protein-Tyrosine Kinases/antagonists & inhibitors.	Biochem Biophys Res Commun 2008 Jan 18;365(3):515-20
Dyrk1A protein, Xenopus	EC 2.7.1.-	Protein-Tyrosine Kinases Protein-Serine-Threonine Kinases *Xenopus Proteins.	Front Biosci 2006 Sep 1;11:2420-7
N-(4-((3,4-dichloro-6-fluoro-phenyl)amino)quinazoline-6-yl)-2-chloroacetamide	0	*Quinazolines Protein-Tyrosine Kinases/antagonists & inhibitors.	Fertil Steril 2007 Jan;87(1):127-35
Tec protein, rat	EC 2.7.1.112	*Protein-Tyrosine Kinases.	Biol Reprod 2006 Jun;74(6):1041-50
Wee1B protein, mouse	EC 2.7.1.-	Protein-Tyrosine Kinases Cell Cycle Proteins.	Curr Biol. 2005 Sep 20;15(18):1670-6
Tnk2 protein, rat	EC 2.7.1.112	*Protein-Tyrosine Kinases.	J Biol Chem 2005 Dec 23;280(51):42219-26
Wee1 protein, Drosophila	EC 2.7.1.112	Nuclear Proteins Protein-Tyrosine Kinases *Cell Cycle Proteins.	Curr Biol 2005 Sep 6;15(17):1525-34
abelson protein, Drosophila	EC 2.7.1.112	Protein-Tyrosine Kinases Drosophila Proteins.	D512-22ev Dyn 2005 Nov;234(3):
FRK-1 protein, C elegans	EC 2.7.1.112	Protein-Tyrosine Kinases Caenorhabditis elegans Proteins.	Development 2005 Jul;132(14):3185-95
2-amino-4-(4'-hydroxyphenyl)-1,1,3-tricyanobuta-1,3-diene	0	Butadienes Nitriles Protein-Tyrosine Kinases/antagonists & inhibitors.	J Neurosci 2004 Nov 24;24(47):10603-15
wzc protein, E coli	EC 2.7.1.112	Membrane Proteins Protein-Tyrosine Kinases *Escherichia coli Proteins.
Wee1A protein, Xenopus	EC 2.7.1.112	Nuclear Proteins Protein-Tyrosine Kinases Cell Cycle Proteins Xenopus Proteins.
WEE1 protein, human	EC 2.7.10.2	Nuclear Proteins Protein-Tyrosine Kinases *Cell Cycle Proteins.
Wee1 protein, mouse	EC 2.7.1.112	Nuclear Proteins Protein-Tyrosine Kinases *Cell Cycle Proteins.
4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	0	*Pyrimidines Protein-Tyrosine Kinases/antagonists & inhibitors.	Cancer Cell 2005 Feb;7(2):117-9	TASIGNA
Tnk2 protein, mouse	EC 2.7.1.-	*Protein-Tyrosine Kinases.
Ack protein, Drosophila	EC 2.7.1.-	Protein-Tyrosine Kinases Drosophila Proteins.
BMX protein, human	EC 2.7.1.-	*Protein-Tyrosine Kinases.
Bmx protein, mouse	EC 2.7.1.-	*Protein-Tyrosine Kinases.
Bmx protein, rat	EC 2.7.1.-	*Protein-Tyrosine Kinases.
Myt1 kinase, rat	EC 2.7.1.-	Protein-Tyrosine Kinases Protein-Serine-Threonine Kinases Membrane Proteins.
PKMYT1 protein, human	EC 2.7.11.1	Membrane Proteins Protein-Tyrosine Kinases *Protein-Serine-Threonine Kinases.
wee-1.3 protein, C elegans	EC 2.7.1.-	Protein-Tyrosine Kinases Protein-Serine-Threonine Kinases *Caenorhabditis elegans Proteins Membrane Proteins.
Ret-Ptc1 oncoprotein, mouse	EC 2.7.1.112	Protein-Tyrosine Kinases Oncogene Proteins, Fusion.
RET-PTC oncoprotein, rat	EC 2.7.1.112	Protein-Tyrosine Kinases Oncogene Proteins, Fusion.
mps1 protein, zebrafish	EC 2.7.1.-	Protein-Tyrosine Kinases Protein-Serine-Threonine Kinases *Zebrafish Proteins.
dasatinib	302962-49-8	Pyrimidines Thiazoles Fluorine Radioisotopes Protein-Tyrosine Kinases/antagonists & inhibitors Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Pharma Action Protein Kinase Inhibitors	Science 2004 Jul 16;305(5682):399-401	SPRYCEL
Aps protein, mouse	0	*Adaptor Proteins, Signal Transducing Protein-Tyrosine Kinases src Homology Domains.
Wee1b protein, Xenopus	EC 2.7.1.-	Xenopus Proteins Protein-Tyrosine Kinases *Cell Cycle Proteins.
Ptk9l protein, mouse	EC 2.7.1.112	Carrier Proteins Protein-Tyrosine Kinases.
Aatk protein, mouse	EC 2.7.1.112	Protein-Tyrosine Kinases Apoptosis Regulatory Proteins.
TWF1 protein, human	EC 2.7.1.112	Microfilament Proteins Protein-Tyrosine Kinases.
v-yes protein, Avian sarcoma virus Y73	EC 2.7.1.112	Protein-Tyrosine Kinases Retroviridae Proteins, Oncogenic Proto-Oncogene Proteins c-yes.
Ros1 protein, rat	EC 2.7.1.112	Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases Protein-Tyrosine Kinases.
Ros1 protein, mouse	EC 2.7.1.112	Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases Protein-Tyrosine Kinases.
MBK-2 protein, C elegans	EC 2.7.1.-	Protein-Tyrosine Kinases Caenorhabditis elegans Proteins.	Dev Cell. 2003 Sep;5(3):451-62
Kos1 protein, mouse	EC 2.7.1.112	*Protein-Tyrosine Kinases.	Oncogene 2003 Jun 5;22(23):3562-77
CpsD protein, Streptococcus pneumoniae	EC 2.7.1.-	*Protein-Tyrosine Kinases.	J Bacteriol 2003 May;185(10):3009-19
Btk29A protein, Drosophila	EC 2.7.1.112	*Protein-Tyrosine Kinases.	Arch Biochem Biophys 2003 May 15;413(2):207-12
Old-2 protein, C elegans	EC 2.7.1.112	Protein-Tyrosine Kinases Caenorhabditis elegans Proteins.	Free Radic Biol Med 2002 Oct 15;33(8):1021-5
TK4 protein, Schistosoma mansoni	EC 2.7.1.112	Protein-Tyrosine Kinases Helminth Proteins.	Gene 2002 Jul 10;294(1-2):87-97
AD034 antigen, human	0	*Antigens, Neoplasm Protein-Tyrosine Kinases.	Cancer Immunol Immunother 2002 Nov;51(10):574-82
AGL 2592	0	Catechols Nitriles Protein-Tyrosine Kinases/antagonists & inhibitors.	J Pharmacol Exp Ther 2002 Oct;303(1):163-71
Wee2 protein, Xenopus	EC 2.7.1.-	Protein-Tyrosine Kinases Xenopus Proteins.	Dev Biol 2002 Sep 1;249(1);156-73
4-(6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide	0	Piperazines Quinazolines Protein-Tyrosine Kinases/antagonists & inhibitors.	J Med Chem 2002 Aug 15;45(17):3772-93
Ksy protein, Xenopus	EC 2.7.1.112	Protein-Tyrosine Kinases Xenopus Proteins.	Gene 2002 Apr 17;288(1-2):29-40
SU 5768	0	*Indoles Protein-Tyrosine Kinases.	Growth Factors 2001;19(1):1-17
Bcr-Abl tyrosine kinase	EC 2.7.1.-	Protein-Tyrosine Kinases Fusion Proteins, bcr-abl.	Lancet 2001 Dec;358 Suppl:S11
OLD-1 protein, C elegans	EC 2.7.1.-	Protein-Tyrosine Kinases Caenorhabditis elegans Proteins.	Curr Biol 2001 Oct 2;11(19):1517-23

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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