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ψ
ψ
Receptor Protein-Tyrosine Kinases
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Definition
: A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
DF: PTK RECEPT
Examples
fms-Like Tyrosine Kinase 3
;
Proto-Oncogene Proteins c-kit
;
Proto-Oncogene Proteins c-met
;
Proto-Oncogene Proteins c-ret
;
Receptor Tyrosine Kinase-like Orphan Receptors
;
Receptor, Epidermal Growth Factor
;
Receptor, erbB-2
;
Receptor, erbB-3
;
Receptor, Fibroblast Growth Factor, Type 1
;
Receptor, Fibroblast Growth Factor, Type 2
;
Receptor, Fibroblast Growth Factor, Type 3
;
Receptor, Fibroblast Growth Factor, Type 4
;
Receptor, IGF Type 1
;
Receptor, Insulin
;
Receptor, Macrophage Colony-Stimulating Factor
;
Receptor, trkA
;
Receptor, trkB
;
Receptor, trkC
;
Receptors, Eph Family
;
Receptors, Platelet-Derived Growth Factor
;
Receptors, TIE
;
Receptors, Vascular Endothelial Growth Factor
Other names
Receptors, Protein Tyrosine Kinase; Receptors, PTK; Receptor, Protein-
Tyrosine Kinase; Receptor Protein Tyrosine Kinases; Receptor Protein Tyrosine Kinase; Protein-
Tyrosine Kinases, Receptor; Protein-
Tyrosine Kinase, Receptor; Protein-
Tyrosine Kinase Receptors; Kinases, Receptor Protein-
Tyrosine; Kinase, Receptor Protein-
Tyrosine; Receptor Protein-
Tyrosine Kinase; Protein-
Tyrosine Kinase Receptor; PTK Receptors; Tyrosine Kinase Receptors; Tyrosine Kinase Linked Receptors; Receptors, Protein-
Tyrosine Kinase
Substance
CAS Registry & name
Categories
Source
Drugs
*
MuSK protein, Xenopus
EC 2.7.1.112
*Receptors, Cholinergic
*Receptor Protein-Tyrosine Kinases
*Xenopus Proteins.
PLoS One. 2011;6(10) (dup#11); e26805
cabozantinib
0
*Anilides
*Pyridines
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
Curr Opin Endocrinol Diabetes Obes 2009 Oct;16(5):367-72
Ryk protein, zebrafish
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases
*Zebrafish Proteins.
J Cell Biol. 2010 Jul 26;190(2):263-78
At2g36570 protein, Arabidopsis
EC 2.7.11.-
*Receptor Protein-Tyrosine Kinases
*Arabidopsis Proteins.
Planta. 2009 Mar;229(4):811-21
Ryk protein, Xenopus
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases.
J Cell Biol 2008 Sep 22;182(6):1073-82
1-
(4-
(3-
amino-
7-
methoxybenzo(d)isoxazol-
4-
yl)phenyl)-
3-
(3-
(trifluoromethyl)phenyl)urea
0
*Isoxazoles
*Phenylurea Compounds
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
J Med Chem 2008 Mar 13;51(5):1231-41
Tyro3 protein, rat
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases.
Neuroscience 2007 Dec 5;150(2):319-34
CAM-
1 protein, C elegans
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
*Caenorhabditis elegans Proteins.
Development 2007 Nov;134(22):4053-62
7-
((1H-
1,2,4-
triazol-
1-
yl)methyl)-
3-
(5-
(3-
(2-
methoxyethoxy)prop-
1-
ynyl)thiophen-
3-
yl)-
1,4-
dihydroindeno(1,2-
c)pyrazole
0
*Pyrazoles
*Thiophenes
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
J Med Chem 2007 May 3;50(9):2011-29
6-
((4-
methylpiperazin-
1-
yl)methyl)-
3-
(5-
(3-
phenoxyprop-
1-
ynyl)thiophen-
3-
yl)-
1,4-
dihydroindeno(1,2-
c)pyrazole
0
*Pyrazoles
*Thiophenes
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
J Med Chem 2007 May 3;50(9):2011-29
MuSK protein, zebrafish
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
*Zebrafish Proteins.
Protein Sci 1998 Jul;7(7):1632-5
5-
((5-
fluoro-
2-
oxo-
1,2-
dihydro-
3H-
indol-
3-
ylidene)methyl)-
N-
(2-
hydroxy-
3-
morpholin-
4-
ylpropyl)-
2,4-
dimethyl-
1H-
pyrrole-
3-
carboxamide
0
*Indoles
*Morpholines
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
Mol Cancer Ther 2006 Jul;5(7):1774-82
N-
(4-
(3-
amino-
1H-
indazol-
4-
yl)phenyl)-
N1-
(2-
fluoro-
5-
methylphenyl)urea
0
*Indazoles
*Phenylurea Compounds
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
Mol Cancer Ther 2006 Apr;5(4):995-1006
Tyro3 protein, mouse
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases.
Nat Immunol 2006 Jul;7(7):747-54
MuSK protein, mouse
EC 2.7.10.1
*Receptor Protein-Tyrosine Kinases.
Science 2006 Jun 23;312(5781):1802-5
DDR1 protein, rat
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases.
Proc Natl Acad Sci U S A 1994 Mar 1;91(5):1819-23
RYK protein, Drosophila
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
*Drosophila Proteins.
Dev Genes Evol 2005 Mar;215(3):158-63
CEP 2563
0
*Carbazoles
*Dipeptides
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
Invest New Drugs 2004 Nov;22(4):449-58
scrambled protein, Arabidopsis
EC 2.7.1.-
*Protein-Serine-Threonine Kinases
*Receptor Protein-Tyrosine Kinases
*Arabidopsis Proteins.
Science 2005 Feb 18;307(5712):1111-3
off-
track protein, Drosophila
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
*Drosophila Proteins.
Development 2004 Nov;131(21):5287-95
LIN-
18 protein, C elegans
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
*Caenorhabditis elegans Proteins.
J Biol Chem 1999 Mar 12;274(11):7379-90
EPHA3 protein, human
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases.
Mertk protein, mouse
EC 2.7.1.112
*Proto-Oncogene Proteins
*Receptor Protein-Tyrosine Kinases.
Mertk protein, rat
EC 2.7.1.112
*Proto-Oncogene Proteins
*Receptor Protein-Tyrosine Kinases.
LTK protein, human
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases.
NOK protein, mouse
EC 2.7.1.112
*Oncogene Proteins
*Receptor Protein-Tyrosine Kinases.
Cancer Res 2004 May 15;64(10):3491-9
PTK7 protein, Xenopus
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases.
Nature 2004 Jul 1;430(6995):93-8
Ptk7 protein, mouse
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases.
Gene 2004 Mar 17;328:75-84
SmRTK-
2, Schistosoma mansoni
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
Helminth Proteins.
J Soc Biol. 2003;197(4):367-73
SmRTK-
1, Schistosoma mansoni
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
Helminth Proteins.
J Soc Biol. 2003;197(4):367-73
SER receptor, Schistosoma mansoni
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
Helminth Proteins.
J Soc Biol. 2003;197(4):367-73
Ryk protein, rat
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases.
Ros1 protein, rat
EC 2.7.1.112
*Proto-Oncogene Proteins
*Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases.
Ros1 protein, mouse
EC 2.7.1.112
*Proto-Oncogene Proteins
*Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases.
STYK1 protein, human
EC 2.7.10.2
*Receptor Protein-Tyrosine Kinases.
Mol Biol Rep 2003 Jun;30(2):91-6
MuSK protein, rat
EC 2.7.1.-
*Receptors, Cholinergic
*Receptor Protein-Tyrosine Kinases.
Structure (Camb). 2002 Sep;10(9):1187-96
SU 11657
0
*Organic Chemicals
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
Blood 2003 Apr 15;101(8):3188-97
Pvr protein, Drosophila
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases
*Drosophila Proteins
Receptors, Platelet-Derived Growth Factor
Receptors, Vascular Endothelial Growth Factor.
Cell 2001 Oct 5;107(1):17-26
lemon protein, Hydra vulgaris
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases.
Dev Biol 2000 Aug 15;224(2):286-98
inrpk1 protein, Ipomoea nil
EC 2.7.1.-
*Plant Proteins
*Receptor Protein-Tyrosine Kinases
Ipomoea.
Plant Mol Biol 2000 May;43(1):43-58
3-
(2-
(5-
bromo-
2-
oxo-
1,2-
dihydroindol-
3-
ylidenemethyl)-
4,5,6,7-
tetrahydro-
1H-
indol-
3-
yl)propionic acid
0
*Indoles
*Propionic Acids
Receptors, Growth Factor/antagonists & inhibitors
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
J Med Chem 2000 Jul 13;43(14):2655-63
3-
(2-
(2-
oxo-
1,2-
dihydroindol-
3-
ylidenemethyl)-
4,5,6,7-
tetrahydro-
1H-
indol-
3-
yl)propionic acid
0
*Indoles
*Propionic Acids
Receptors, Growth Factor/antagonists & inhibitors
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
J Med Chem 2000 Jul 13;43(14):2655-63
sweet tooth protein, Hydra vulgaris
EC 2.7.11.-
*Receptor Protein-Tyrosine Kinases
Lectins, C-Type.
J Biol Chem 2000 Apr 7;275(14):10323-30
LRPKM1 protein, Malus domestica
EC 2.7.11.-
*Plant Proteins
*Receptor Protein-Tyrosine Kinases.
Plant Mol Biol 1999 Aug;40(6):945-57
CLV1 protein, Arabidopsis
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases
*Arabidopsis Proteins.
Cell 1997 May 16;84(4):575-85
Ryk protein, mouse
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases.
J Biol Chem 1999 Mar 12;274(11):7379-90
PD 173074
0
*Pyrimidines
Receptors, Fibroblast Growth Factor/antagonists & inhibitors
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
EMBO J 1998 Oct 15;17(20):5896-904
NSK2 protein, Drosophila
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases
*Drosophila Proteins.
Oncogene 1995 Jul 20;11(2):281-90
ET(B)R-
LP-
2 protein, human
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases
Nerve Tissue Proteins.
FEBS Lett 1998 Mar 13;424(3):193-6
vab-
1 protein, C elegans
EC 2.7.1.112
*Cell Cycle Proteins
*Receptor Protein-Tyrosine Kinases
*Caenorhabditis elegans Proteins.
Cell 1998 Mar 6;92(5):633-43
Epha3 protein, rat
EC 2.7.1.112
*Receptor Protein-Tyrosine Kinases.
Am J Physiol 1998 Jan;274(1 Pt 2):H331-41
GAP-
1 protein, C elegans
EC 2.7.1.-
*ras GTPase-Activating Proteins
*Receptor Protein-Tyrosine Kinases
*Caenorhabditis elegans Proteins.
Genes Dev 1997 Oct 15;11(20):2715-28
Ki 6783
0
*Quinolines
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
Exp Cell Res 1997 Aug 1;234(2):285-92
EPHB6 protein, human
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases.
Biochem Biophys Res Commun 1997 Jun 27;235(3):487-92
6,7-
dimethoxy-
3-
phenylquinoxaline
146535-11-7
*Tyrphostins
Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
Biochemistry 1997 May 27;36(21):6260-9
Nrk protein, Drosophila
EC 2.7.1.-
*Nerve Tissue Proteins
*Receptor Protein-Tyrosine Kinases
*Drosophila Proteins.
J Biol Chem 1997 May 2;272(18):11916-23
SDZ 281 977
0
*Benzoates
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors.
Int J Cancer 1996 Jan 26;65(3):351-9
MERTK protein, human
EC 2.7.1.112
*Proto-Oncogene Proteins
*Receptor Protein-Tyrosine Kinases.
Cell Growth Differ 1994 Jun;5(6):647-57; Hum Mol Genet 2000 Mar 1;9(4):645-51; Mol Cell Biol 1995 Dec;15(12):6582-92
PTK7 protein, human
EC 2.7.1.-
*Cell Adhesion Molecules
*Receptor Protein-Tyrosine Kinases.
Oncogene 1995 Nov 16;11(10):2179-84
TCK recceptor-
tyrosine kinase, Xenopus
EC 2.7.1.-
*Receptor Protein-Tyrosine Kinases
*Xenopus Proteins.
Oncogene 1995 Nov 2;11(9):1745-52
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