Definition: Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.
DF: C MET PROTEINS
Other names met Proto Oncogene Proteins; c met Proteins; Proto-Oncogene Proteins, met; Proto Oncogene Proteins c met; Scatter Factor Receptor; Receptor, Scatter Factor; Receptor, Hepatocyte Growth Factor; Receptor, HGF; met Proto-Oncogene Proteins; c-met Proteins; Hepatocyte Growth Factor Receptor; HGF Receptor
