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Receptor, erbB-2

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Definition: A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR), the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members.     
See Also Genes, erbB-2 		Other names neu Proto Oncogene Protein; erbB-2 Receptors; erbB-2 Receptor; erbB 2 Receptor Protein Tyrosine Kinase; erbB 2 Proto Oncogene Protein; c erbB 2 Protein; Receptors, erbB 2; Receptor, erbB 2; Proto-Oncogene Protein, neu; Proto-Oncogene Protein, erbB-2; Proto-Oncogene Protein, HER-2; Proto Oncogene Proteins c erbB 2; Proto Oncogene Protein HER 2; Oncogene Protein HER 2; HER 2 Proto Oncogene Protein; p185(c-neu); Receptors, erbB-2; Proto-Oncogene Proteins c-erbB-2; Oncogene Protein HER-2; neu Proto-Oncogene Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
XL647  0   *Quinazolines *Azabicyclo Compounds Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors Receptor, EphB4/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. Clin Cancer Res. 2007 Jun 15;13(12):3713-23.
HER2 peptide (369-377)  0   *Peptide Fragments *Receptor, erbB-2 Cancer Vaccines. Pathol Biol (Paris) 2011 Jun;59(3):173-82
1-acryloyl-N-(4-(3-chloro-2,4-difluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide  0   *Aniline Compounds *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6880-8
1-acryloyl-N-(4-(3-chloro-2-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide  0   *Aniline Compounds *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6880-8
HER2 protein, human  0   *Receptor, erbB-2. N Engl J Med. 2009 Aug 13;361(7):699-707
MP 412  0   *Piperazines *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors. Cancer Sci 2007 Dec;98(12):1977-84
HER-2 protein (435-443)  0   *Peptide Fragments *Receptor, erbB-2. Int J Cancer 2007 Nov 1;121(9):2031-41
HER-2 protein (776-790)  0   *Peptide Fragments *Receptor, erbB-2. Int J Cancer 2007 Nov 1;121(9):2031-41
Erbb2 protein, mouse  EC 2.7.10.1   *Receptor, erbB-2. Mol Cell Biol 1986 May;6(5):1729-40
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide  0   *Quinazolines Receptor, erbB-2/antagonists & inhibitors. Clin Cancer Res 2007 Feb 15;13(4):1238-45
111In-benzyl-DTPA-ZHER2:342  0   *Receptor, erbB-2 Pentetic Acid/*analogs & derivatives Indium Radioisotopes. J Nucl Med. 2006 May;47(5):846-53
ERBB2 protein, human  EC 2.7.10.1   *Receptor, erbB-2. Breast Cancer Res 2005;7(5):R598-604
pertuzumab  380610-27-5   *Antibodies, Monoclonal, Humanized Breast Neoplasms Receptor, erbB-2. Cancer Res. 2004 Apr 1;64(7):2343-6
Erbb2 protein, rat  0   *Receptor, erbB-2 Oncogene Proteins.
HER2p63 peptide  0   *Peptide Fragments *Receptor, erbB-2. Blood 2002 May 15;99(10):3717-24
HER2(776-788)  0   *Peptide Fragments *Receptor, erbB-2. Br J Cancer 2001 Nov 16;85(10):1527-34
HER-2-derived peptide 884-899  0   *Peptide Fragments Receptor, erbB-2. Cancer Immunol Immunother 2002 Jan;50(11):615-24
herstatin  0   *Intercellular Signaling Peptides and Proteins Receptor, erbB-2. Oncogene 2001 Aug 23;20(37):5199-209
HER2-neu-derived peptide (780-786)  0   *Peptide Fragments *Receptor, erbB-2 Antigens, Neoplasm. Int J Cancer 2000 Aug 15;87(4):553-8
trastuzumab  0   *Antibodies, Monoclonal, Humanized Breast Neoplasms Receptor, erbB-2.
Pharma Action Antineoplastic Agents 		J Natl Cancer Inst 1998 Jun 17;90(12):882-3HERCEPTIN
GD5 protein, recombinant  0   *Diphtheria Toxin *Recombinant Fusion Proteins *Receptor, erbB-2 *Single-Chain Antibodies Genetic Vectors. J Biol Chem 1998 Apr 10;273(15):8835-41
Lcn2 protein, rat  0   *Lipocalins Receptor, erbB-2. Oncogene 1995 Dec 7;11(11):2233-41
HER2-neu-derived peptide (654-662)  0   *Peptide Fragments *Receptor, erbB-2 Antigens, Neoplasm. Proc Natl Acad Sci U S A 1995 Jan 17;92(2):432-6
epidermal growth factor receptor-neu receptor  0   *Receptor, Epidermal Growth Factor *Receptor, erbB-2. Oncogene 1990;5(6):815

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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