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Antibodies, Monoclonal, Humanized

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Definition: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.      Other names Humanized Antibodies; Antibodies, Humanized
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
zirconium-89-trastuzumab  0   *Antibodies, Monoclonal, Humanized Zirconium. J Nucl Med. 2009 Jun;50(6):974-81.
benralizumab  0   *Antibodies, Monoclonal, Humanized. Expert Opin Biol Ther. 2012 Jan;12(1):113-8
ASK8007 monoclonal antibody  0   *Antibodies, Monoclonal, Humanized Osteopontin/antagonists & inhibitors. Ann Rheum Dis. 2012 Feb;71(2):180-5
SAR 3419  0   *Antibodies, Monoclonal, Humanized Maytansine/*analogs & derivatives Immunotoxins. Clin Cancer Res. 2009 Jun 15;15(12):4038-45.
RG 7160  0   *Glycoproteins *Antibodies, Monoclonal, Humanized. J Clin Oncol. 2011 Oct 1;29(28):3783-90.
PF-03732010 monoclonal antibody  0   *Antibodies, Monoclonal, Humanized. Clin Cancer Res 2010 Nov 1;16(21):5177-88
thorium-227-p-isothiocyanato-benzyl-DOTA-trastuzumab  0   *Organometallic Compounds *Antibodies, Monoclonal, Humanized Thorium. Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2)
tigatuzumab  918127-53-4   *Antibodies, Monoclonal, Humanized. Cancer Biother Radiopharm. 2010 Feb;25(1):13-9
trastuzumab-DM1 conjugate  0   *Antibodies, Monoclonal, Humanized Maytansine/*analogs & derivatives Immunotoxins. Cancer Res 2008 Nov 15;68(22):9280-90
otelixizumab  0   *Antibodies, Monoclonal, Humanized. Diabetes Metab Res Rev 2009 May;25(4):302-6
solanezumab  0   *Antibodies, Monoclonal, Humanized. Clin Neuropharmacol 2010 Mar-Apr;33(2):67-73
tanezumab  0   *Antibodies, Monoclonal, Humanized Receptor, Nerve Growth Factor/antagonists & inhibitors. Curr Opin Mol Ther 2010 Feb;12(1):94-106
LY2439821  0   *Antibodies, Monoclonal, Humanized. Arthritis Rheum. 2010 Apr;62(4):929-39
mogamulizumab  0   *Antibodies, Monoclonal, Humanized. J Clin Oncol 2010 Mar 20;28(9):1591-8
gevokizumab  0   *Antibodies, Monoclonal, Humanized. Drug News Perspect. 2009 Oct;22(8):497
64Cu-DOTA-trastuzumab  0   *Organometallic Compounds *Antibodies, Monoclonal, Humanized Copper. Eur J Nucl Med Mol Imaging 2009 Sep;36(9):1510-9
ALD518 monoclonal antibody  0   *Antibodies, Monoclonal, Humanized. Nat Rev Drug Discov. 2010 Jan;9(1):10
elotuzumab  0   *Antibodies, Monoclonal, Humanized. Mol Cancer Ther 2009 Sep;8(9):2616-24
AVE1642  0   *Antibodies, Monoclonal, Humanized. Clin Cancer Res. 2009 Sep 1;15(17):5445-56
bapineuzumab  0   *Antibodies, Monoclonal, Humanized. Nat Biotechnol 2009 Aug;27(8):679-81
siplizumab  0   *Antibodies, Monoclonal, Humanized. Clin Cancer Res 2009 Apr 1;15(7):2514-22
vedolizumab  0   *Antibodies, Monoclonal, Humanized. J Pharmacol Exp Ther. 2009 Sep;330(3):864-75
afutuzumab  0 Immunoglobulin G1, anti-(human CD20 (antigen)) (human-mouse monoclonal GA101 heavy chain), disulfide with human-mouse monoclonal GA101 KAPPA-chain, dimer  *Antibodies, Monoclonal, Humanized. Curr Opin Investig Drugs 2009 Jun;10(6):588-96
dacetuzumab  0   *Antibodies, Monoclonal, Humanized. Curr Opin Investig Drugs 2009 Jun;10(6):579-87
MEDI-528  0   *Antibodies, Monoclonal, Humanized. Clin Ther 2009 Apr;31(4):728-40
milatuzumab  0   *Antibodies, Monoclonal, Humanized. Clin Cancer Res 2009 Apr 15;15(8):2808-17
188Re-SOCTA-trastuzumab  0   *Organometallic Compounds *Antibodies, Monoclonal, Humanized Rhenium. Nucl Med Biol 2009 Jan;36(1):81-8
111In-DTPA-trastuzumab  0   *Organometallic Compounds *Antibodies, Monoclonal, Humanized Indium Radioisotopes. Eur J Nucl Med Mol Imaging 2009 Jan;36(1):81-93
ocrelizumab  0   *Antibodies, Monoclonal, Humanized. Curr Opin Investig Drugs 2008 Nov;9(11):1206-15
farletuzumab  0   *Antibodies, Monoclonal, Humanized. Curr Opin Investig Drugs 2007 Dec;8(12):1067-73
(111In-DTPA)n-trastuzumab-(IRDye800)m  0   *Organometallic Compounds *Antibodies, Monoclonal, Humanized Indium. J Nucl Med 2007 Sep;48(9):1501-10
Hu3S193 monoclonal antibody  0   *Antibodies, Monoclonal, Humanized. Clin Cancer Res 2007 Jun 1;13(11):3286-92
herceptin-rhodamine green conjugate  0   *Rhodamines *Antibodies, Monoclonal, Humanized. Clin Cancer Res 2007 May 15;13(10):2936-45
matuzumab  0   *Antibodies, Monoclonal, Humanized. Clin Colorectal Cancer. 2005 Apr;5 Suppl 1:S19-27
bivatuzumab mertansine  0   *Antibodies, Monoclonal, Humanized Maytansine/*analogs & derivatives. Int J Oncol 2007 Apr;30(4):927-35
reslizumab  0   *Antibodies, Monoclonal, Humanized. J Allergy Clin Immunol 2006 Nov;118(5):1133-41
TRX-4 monoclonal antibody  0   *Antibodies, Monoclonal, Humanized. IDrugs 2006 Apr;9(4):283-91
TGN-1412 monoclonal antibody  0   *Antibodies, Monoclonal, Humanized. BMJ 2006 Mar 25;332(7543):677-8
motavizumab  0   *Antibodies, Monoclonal, Humanized. Antimicrob Agents Chemother. 2005 Nov;49(11):4700-7
huN901-DM1  0   *Antibodies, Monoclonal, Humanized. Curr Opin Mol Ther 2005 Aug;7(4):394-401
fontolizumab  0   *Antibodies, Monoclonal, Humanized. Curr Opin Investig Drugs 2005 May;6(5):537-44
PRO70769 monoclonal antibody  0   *Antibodies, Monoclonal, Humanized. J Immunother 2005 May-Jun;28(3):212-9
tocilizumab  0   *Antibodies, Monoclonal, Humanized. Nippon Rinsho 2005 May;63 Suppl 5:723-7ACTEMRA
teplizumab  0   *Antibodies, Monoclonal, Humanized. Diabetes 2005 Jun;54(6):1763-9
TheraCIM  0   *Antibodies, Monoclonal, Humanized. Biotechnol Bioeng 2005 Jan 20;89(2):188-94
nimotuzumab  0 Immunoglobulin G1, anti-(humanized mouse monoclonal hR3 beta1 chain anti-human epidermal growth factor receptor), disulfide with humanized mouse monoclonal hR3 kappa-chain, dimer  *Antibodies, Monoclonal, Humanized. Curr Opin Mol Ther 2005 Apr;7(2):182-91
MLN02 antibody, human  0   *Antibodies, Monoclonal, Humanized. N Engl J Med. 2005 Jun 16;352(24):2499-507
ranibizumab  0   *Antibodies, Monoclonal, Humanized Macular Degeneration. Invest Ophthalmol Vis Sci 2005 Feb;46(2):726-33LUCENTIS
veltuzumab  0   *Antibodies, Monoclonal, Humanized. Clin Cancer Res 2004 Apr 15;10(8);2868-78
pertuzumab  380610-27-5   *Antibodies, Monoclonal, Humanized Breast Neoplasms Receptor, erbB-2. Cancer Res. 2004 Apr 1;64(7):2343-6
cantuzumab mertansine  0   *Antibodies, Monoclonal, Humanized Maytansine/*analogs & derivatives. J Pharmacol Exp Ther. 2004 Mar;308(3):1073-82
eculizumab  0   *Antibodies, Monoclonal, Humanized. N Engl J Med 2004 Feb 5;350(6):552-9SOLIRIS
Inotuzumab Ozogamicin  0   *Antibodies, Monoclonal, Humanized. Curr Opin Pharmacol 2003 Aug;3(4);386-90
monoclonal antibody BIWA 4  0   *Antibodies, Monoclonal, Humanized. Cancer Immunol Immunother 2003 Sep;52(9):576-82
lintuzumab  0   *Antibodies, Monoclonal, Humanized. Clin Lymphoma. 2002 Jun;3(1):18-9
sibrotuzumab  0   *Antibodies, Monoclonal, Humanized. Onkologie. 2003 Feb;26(1):44-8
99mTc-hR3 monoclonal antibody  0   *Organotechnetium Compounds *Antibodies, Monoclonal, Humanized. Nucl Med Commun 2002 Dec;23(12):1155-64
talizumab  0   *Antibodies, Monoclonal, Humanized. N Engl J Med 2003 Mar 13;348(11):975-6
bevacizumab  0   *Antibodies, Monoclonal, Humanized Vascular Endothelial Growth Factor A.
Pharma Action Angiogenesis Inhibitors 		Curr Oncol Rep 2002 Sep;4(5):369-74AVASTIN
natalizumab  0   *Antibodies, Monoclonal, Humanized Cell Migration Inhibition Multiple Sclerosis Integrin alpha4. Nervenarzt 2002 Jun;73(6):552-5TYSABRI
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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