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Diphtheria Toxin

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Definition: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.  /antag permitted but consider also DIPHTHERIA ANTITOXIN   
Pharmacological Action Poisons
See Also Diphtheria Toxoid 		Other names Corynebacterium Diphtheriae Toxin; Toxin, Corynebacterium Diphtheriae
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DT 2219 immunotoxin  0   *Antibodies *Diphtheria Toxin Immunotoxins. Clin Cancer Res 2005 May 15;11(10):3879-88
VEGF121-diphtheria toxin conjugate  0   *Diphtheria Toxin *Angiogenic Proteins. Br J Cancer 2000 Oct;83(8):1077-83
diphtheria toxin-interleukin-3 fusion protein, recombinant  0   *Diphtheria Toxin *Interleukin-3 *Recombinant Fusion Proteins. Leukemia 2000 Apr;14(4):576-85
FN18-CRM9  0   *Antibodies, Monoclonal *Diphtheria Toxin Recombinant Fusion Proteins Immunotoxins Graft Rejection Lymphocyte Depletion. Transplant Proc 1998 Aug;30(5):2150-1
DTctGMCSF protein, recombinant  0   *Diphtheria Toxin *Recombinant Fusion Proteins *Granulocyte-Macrophage Colony-Stimulating Factor. Protein Expr Purif 1998 Jul;13(2):210-21
dt(388) granulocyte-macrophage colony-stimulating factor  0   *Diphtheria Toxin *Granulocyte-Macrophage Colony-Stimulating Factor Immunotoxins. Toxicol Appl Pharmacol 1998 May;150(1):91-7
DAB(389) interleukin-7  0   *Diphtheria Toxin *Interleukin-7 Immunotoxins. Bioconj Chem 1998 Mar-Apr;9(2):201-7
GD5 protein, recombinant  0   *Diphtheria Toxin *Recombinant Fusion Proteins *Receptor, erbB-2 *Single-Chain Antibodies Genetic Vectors. J Biol Chem 1998 Apr 10;273(15):8835-41
DT390-anti-CD3sFv  0   *Diphtheria Toxin *Immunoglobulin Fragments *Recombinant Fusion Proteins Immunotoxins Graft vs Host Disease. Protein Eng 1997 Sep;10(9):1071-6
DAB(389)-(Gly(4)-Ser)2-interleukin 3  0   *Diphtheria Toxin *Interleukin-3 Recombinant Fusion Proteins. FEBS Lett 1997 Apr 7;406(1-2):157-61
DAB(389)-GRP fusion protein, recombinant  0   *Diphtheria Toxin *Peptides *Recombinant Fusion Proteins. Cancer Res 1997 Jan 15;57(2):290-4
DAB(389)-interleukin 4  0   *Diphtheria Toxin *Interleukin-4 Recombinant Fusion Proteins Immunotoxins. J Allergy Clin Immunol 1995 Apr;95(4):893-900
CRM 288  0   *Diphtheria Toxin. J Bacteriol 1994 Aug;176(15):4766-9
DAB(389)-interleukin 6  0   *Diphtheria Toxin *Interleukin-6 Recombinant Fusion Proteins. Protein Eng 1993 Apr;6(3):305-11
denileukin diftitox  173146-27-5   *Diphtheria Toxin *Interleukin-2 Recombinant Fusion Proteins.
Pharma Action Antineoplastic Agents 		J Acquir Immune Defic Syndr 1992 Dec;5(12):1181-7ONTAK
diphtheria toxin-related-murine interleukin-4-fusion toxin  0   *Diphtheria Toxin *Interleukin-4 Recombinant Fusion Proteins. Protein Eng 1992 Apr;5(3):241-8
diphtheria toxin-related-alpha-melanocyte-stimulating hormone fusion toxin  0   *alpha-MSH *Diphtheria Toxin Recombinant Fusion Proteins. J Biol Chem 1991;266(19):12289
interleukin 2-diphtheria toxin  0   *Diphtheria Toxin *Interleukin-2 Recombinant Fusion Proteins. Int J Cancer 1990;45(1):163
CRM 107  0   *Diphtheria Toxin. J Neurosurg 1989;70(2):241
DAB(486)-interleukin 2  0   *Diphtheria Toxin *Interleukin-2 Recombinant Fusion Proteins Immunotoxins.
Pharma Action Antineoplastic Agents ; Antirheumatic Agents 		Am J Kid Dis 1988;11(2):159
CRM9 protein, bacteria  0   *Bacterial Proteins Diphtheria Toxin. Biochim Biophys Acta 1987;902(1):24
human chorionic gonadotropin-diphtheria toxin fragment A  0   *Diphtheria Toxin *Chorionic Gonadotropin Recombinant Fusion Proteins Artificial Gene Fusion. Biochem Biophys Res Commun 1985;133(2):430
transferrin-diphtheria toxin conjugate  0   *Diphtheria Toxin Transferrin/*analogs & derivatives. J Biol Chem 1985;260(2):932
diphtheria toxin fragment B  0   *Diphtheria Toxin Peptide Fragments. FEBS Lett 1983;160(1-2):82
CRM45 fragment of diphtheria toxin  0   *Bacterial Proteins Cross Reactions Diphtheria Toxin. J Infect Dis 1982;145(1):94
insulin crosslinked to the catalytic fragment A of diphtheria toxin  0   *Diphtheria Toxin *Insulin Immunotoxins.
Pharma Action Cytotoxins 		Proc Natl Acad Sci USA 1981;78(1):445
diphtheria toxin fragment A  0   *Diphtheria Toxin *Peptide Fragments. Exp Cell Res 1981;132(2):259
hybrid toxin, diphtheria-cholera  0   *Cholera Toxin *Diphtheria Toxin. Biochim Biophys Acta 1980;626(2):443
CRM197 (non-toxic variant of diphtheria toxin)  92092-36-9   *Bacterial Proteins Diphtheria Toxin. J Infect Dis 1980;142(5):716

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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