encyclopedia of medical concepts
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fms-Like Tyrosine Kinase 3
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Definition
: A receptor tyrosine kinase that is involved in HEMATOPOIESIS. It is closely related to FMS PROTO-ONCOGENE PROTEIN and is commonly mutated in acute MYELOID LEUKEMIA.
Other names
fms Like Tyrosine Kinase 3; Fetal Liver Kinase 3; Fetal Liver Kinase 2; Antigen, CD135; Stem Cell Tyrosine Kinase 1; Fetal Liver Kinase-
3; Fetal Liver Kinase-
2; CD135 Antigen; CD135 Antigens; Antigens, CD135
Substance
CAS Registry & name
Categories
Source
Drugs
*
11-
(2-
pyrrolidin-
1-
ylethoxy)-
14,19-
dioxa-
5,7,26-
triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-
1(25),2(26),3,5,8,10,12(27),16,21,23-
decaene
0
*Bridged Compounds
*Pyrimidines
fms-Like Tyrosine Kinase 3/antagonists & inhibitors
Janus Kinase 2/antagonists & inhibitors.
J Med Chem 2011 Jul 14;54(13):4638-58
FLT3 protein, rat
EC 2.7.1.112
*fms-Like Tyrosine Kinase 3.
J Gastroenterol Hepatol 2007 Dec;22(12):2181-8
Flt3 protein, mouse
EC 2.7.1.112
*fms-Like Tyrosine Kinase 3.
FLT3 protein, human
EC 2.7.10.1
*fms-Like Tyrosine Kinase 3.