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Receptor, trkA

More information in Books or onNLM PubMed
Definition: A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.  DF: RECEPT TRKA    Other names trk, Proto-Oncogene Protein; trk Proto Oncogene Protein; p140 trkA; gp140 c trk; c-trk, gp140; c-trk, Proto-Oncogene Products; c trk Protein; Receptor, NTRK1; Proto-Oncogene Protein, trk; Proto Oncogene Protein trk; Proto Oncogene Products c trk; trk1 Transforming Tryrosine Kinase; p140-trkA; gp140 c-trk; c-trk Protein; Proto-Oncogene Products c-trk; Neurotrophic Tyrosine Kinase Receptor Type 1; trkA Receptor; trk Proto-Oncogene Protein; gp140(c-TRK)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tyrosine receptor kinase A Ig2  0   *Receptor, trkA. J Urol 2005 Mar;173(3):1016-21
D3 compound  0   *Peptides, Cyclic Receptor, trkA/agonists. Mol Pharmacol 2000 Feb;57(2):385-91

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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