Definition: A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
DF: RECEPT TRKA
Other names trk, Proto-Oncogene Protein; trk Proto Oncogene Protein; p140 trkA; gp140 c trk; c-trk, gp140; c-trk, Proto-Oncogene Products; c trk Protein; Receptor, NTRK1; Proto-Oncogene Protein, trk; Proto Oncogene Protein trk; Proto Oncogene Products c trk; trk1 Transforming Tryrosine Kinase; p140-trkA; gp140 c-trk; c-trk Protein; Proto-Oncogene Products c-trk; Neurotrophic Tyrosine Kinase Receptor Type 1; trkA Receptor; trk Proto-Oncogene Protein; gp140(c-TRK)