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Receptor Tyrosine Kinase-like Orphan Receptors

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Definition: A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.  do not confuse with ORPHAN NUCLEAR RECEPTORS    Other names Tyrosine Kinase, ROR1; Receptor Tyrosine Kinase like Orphan Receptors; Receptor Tyrosine Kinase like Orphan Receptor 2; Receptor Tyrosine Kinase like Orphan Receptor 1; Neurotrophic Tyrosine Kinase, Receptor related Pro; Kinase, ROR2 Tyrosine; Receptor Tyrosine Kinase-like Orphan Receptor 2; Receptor Tyrosine Kinase-like Orphan Receptor 1; ROR2 Tyrosine Kinase; ROR1 Tyrosine Kinase; ROR Tyrosine Kinase Receptors; Neurotrophic Tyrosine Kinase, Receptor-related Pro; NTRKR Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ror2 protein, rat  EC 2.7.10.1   *Receptor Tyrosine Kinase-like Orphan Receptors. Int J Mol Med 2005 Mar;15(3):533-8
Ror1 protein, rat  EC 2.7.10.1   *Receptor Tyrosine Kinase-like Orphan Receptors. Int J Mol Med 2005 Mar;15(3):533-8
Ror1 protein, mouse  EC 2.7.10.1   *Receptor Tyrosine Kinase-like Orphan Receptors. J Biol Chem 2003 Aug 1;278(31):29057-64
Ror2 protein, mouse  EC 2.7.10.1   *Receptor Tyrosine Kinase-like Orphan Receptors. J Biol Chem 2003 Aug 1;278(31):29057-64
ROR2 protein, human  0   *Receptor Tyrosine Kinase-like Orphan Receptors. J Biol Chem 1992 Dec 25;267(36):26181-90
ROR1 protein, human  EC 2.7.10.1   *Receptor Tyrosine Kinase-like Orphan Receptors. J Biol Chem 1992 Dec 25;267(36):26181-90

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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