Definition: Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
Other names src Homology Domain; SH3 Domains; SH2 Domains; SH1 Domains; SH Domain; Homology Domains, src; Homology Domain, src; src Homology Region 2 Domain; SH3 Domain; SH2 Domain; SH1 Domain; SH Domains