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Phosphoprotein Phosphatases

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Definition: A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)  general; prefer specifics   
Examples Calcineurin; Dual-Specificity Phosphatases; Glycogen-Synthase-D Phosphatase; Myosin-Light-Chain Phosphatase; Phosphorylase Phosphatase; Protein Phosphatase 1; Protein Phosphatase 2; Pyruvate Dehydrogenase (Lipoamide)-Phosphatase 		Other names Protein Phosphatases; Phosphoprotein Phosphohydrolase; Phosphoprotein Phosphatase; Serine Threonine Phosphatase; Protein Threonine Phosphatase; Protein Serine Threonine Phosphatase; Protein Phosphatase, Nuclear; Protein Phosphatase H II; Protein Phosphatase C II; Protein Phosphatase C I; Phosphoseryl Protein Phosphatase; Phosphoprotein Phosphatase 2C; Phosphohydrolase, Phosphoprotein; Phosphatases, Protein; Phosphatases, Phosphoprotein; Phosphatase-2C, Phosphoprotein; Phosphatase, Threonine; Phosphatase, Serine-Threonine; Phosphatase, Protein-Threonine; Phosphatase, Protein-Serine-Threonine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Cdc25 protein, S pombe  EC 3.1.3.16   *Phosphoprotein Phosphatases *Schizosaccharomyces pombe Proteins. Biochem Biophys Res Commun. 2012 Jan 6;417(1): 613-8
STP1 protein, rat  EC 3.1.3.16   *Phosphoprotein Phosphatases. J Biol Chem. 2011 Dec 23;286(51):44197-210.
Flapwing protein, Drosophila  EC 3.1.3.16   *Phosphoprotein Phosphatases *Drosophila Proteins. Dev Biol. 2012 Jan 15;361(2);412-26
CTDSP2 protein, zebrafish  EC 3.1.3.16   *Phosphoprotein Phosphatases *Zebrafish Proteins. Genes Dev. 2012 Jan 1;26(1):25-30
Smek2 protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases. Cell Res 2011 Jun;21(6):911-21
Smek1 protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases Protein Subunits. Cell Res 2011 Jun;21(6):911-21
R3F protein, rat  EC 3.1.3.-   *Carrier Proteins *Phosphoprotein Phosphatases Membrane Proteins. J Neurochem 2011 Aug;118(4):596-610
MK-STYX protein, human  0   *Apoptosis Regulatory Proteins Phosphoprotein Phosphatases. Mol Cell Biol 2011 Apr;31(7):1357-68
CTD small phosphatase like 2, human  EC 3.1.3.16   *Phosphoprotein Phosphatases. BMC Cell Biol 2010;11:75
TAP38 protein, Arabidopsis  EC 3.1.3.16   *Phosphoprotein Phosphatases *Arabidopsis Proteins Plastids. PLoS Biol. 2010;8(1) (dup#5):e1000288
Cdc25.2 protein, C elegans  EC 3.1.3.16   *Phosphoprotein Phosphatases *Caenorhabditis elegans Proteins Cell Cycle Proteins. J Cell Sci 2010 Mar 15;123(Pt 6):993-1000
calyculin C  0   *Oxazoles Phosphoprotein Phosphatases/antagonists & inhibitors. Mar Drugs. 2010;8(1):122-72
PHLPP2 protein, human  EC 3.1.3.16   *Phosphoprotein Phosphatases. J Biol Chem 2009 May 29;284(22):15215-23
isocitrate dehydrogenase kinase-phosphatase, E coli  EC 2.7.11.5   *Multienzyme Complexes *Escherichia coli Proteins Phosphoprotein Phosphatases Protein-Serine-Threonine Kinases. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 May 1;65(Pt 5):536-9
PHLPP2 protein, rat  EC 3.1.3.16   *Phosphoprotein Phosphatases. Biochem Biophys Res Commun 2009 Jun 26;384(2):193-8
Fcp1 protein, Drosophila  EC 3.1.3.16   *Phosphoprotein Phosphatases *Drosophila Proteins. Cell Mol Life Sci 2009 Mar;66(5):909-18
SCPL-1 protein, C elegans  EC 3.1.3.16   *Phosphoprotein Phosphatases *Caenorhabditis elegans Proteins. J Mol Biol 2009 Mar 6;386(4):976-88
7-deoxyokadaic acid  0   Okadaic Acid/*analogs & derivatives Phosphoprotein Phosphatases/antagonists & inhibitors. J Org Chem 2009 Jan 16;74(2):910-3
At1g05000 protein, Arabidopsis  EC 3.1.3.16   *Phosphoprotein Phosphatases *Arabidopsis Proteins. Proteins 2008 Oct;73(1):241-53
Psy4 protein, S cerevisiae  EC 3.1.3.-   *Saccharomyces cerevisiae Proteins Phosphoprotein Phosphatases Protein Subunits. FEBS J 2008 Aug;275(16):4211-21
SSH1 protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases. Genesis 2008 May;46(5):246-55
SSH3 protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases. Genesis 2008 May;46(5):246-55
Ppm1l, protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases. Nature. 2008 Mar 27;452(7186):429-35
PPP1R16A protein, mouse  0   *Carrier Proteins *Membrane Proteins Phosphoprotein Phosphatases. Mol Pharmacol 2008 Apr;73(4):1113-21
PPP1R3A protein, mouse  EC 3.1.3.-   *Phosphoprotein Phosphatases. PLos Med 2008 Jan 29;5(1):e27
SMK-1 protein, C elegans  EC 3.1.3.16   *Phosphoprotein Phosphatases *Caenorhabditis elegans Proteins. J Cell Biol 2007 Oct 8;179(1):41-52
slingshot phosphatase 2, human  EC 3.1.3.16   *Phosphoprotein Phosphatases. Proteins 2007 Jul 1;68(1):408-12
AP2C1 protein, Arabidopsis  EC 3.1.3.16   *Phosphoprotein Phosphatases *Arabidopsis Proteins. Plant Cell 2007 Jul;19(7):2213-24
PP1delta protein, rat  EC 3.1.3.16   *Phosphoprotein Phosphatases. Biochem J 2007 Nov 15;408(1):7-18
Dusp27 protein, human  EC 3.1.3.16   *Phosphoprotein Phosphatases. FEBS Lett 2007 May 29;581(13):2527-33
MDP-1 protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases.
MDP-1 protein, human  EC 3.1.3.-.   *Phosphoprotein Phosphatases.
PPM1L protein, human  EC 3.1.3.16   *Phosphoprotein Phosphatases.
PPM1H protein, human  EC 3.1.3.16   *Phosphoprotein Phosphatases.
PPM1M protein, human  EC 3.1.3.16   *Phosphoprotein Phosphatases.
Phlpp protein, mouse  EC 3.1.3.16   *Nuclear Proteins *Phosphoprotein Phosphatases Nerve Tissue Proteins. Cell 2007 Mar 23;128(6):1029-30
PTC6 protein, S cerevisiae  EC 3.1.3.16   *Phosphoprotein Phosphatases *Saccharomyces cerevisiae Proteins Mitochondrial Proteins. J Biol Chem 2007 Feb 23;282(8):5617-24
ppm1e protein, Zebrafish  EC 3.1.3.16   *Phosphoprotein Phosphatases *Zebrafish Proteins. Arch Biochem Biophys 2007 Jan 15;457(2):205-16
Mag1 protein, Arabidopsis  0   *Arabidopsis Proteins *Vesicular Transport Proteins Phosphoprotein Phosphatases. Plant Cell Physiol 2006 Sep;47(9):1187-94
PPP1R16A protein, human  0   *Carrier Proteins *Membrane Proteins Phosphoprotein Phosphatases. J Biol Chem 2006 Oct 20;281(42):31202-11
HAB1 protein, Arabidopsis  EC 3.1.3.16   *Phosphoprotein Phosphatases *Arabidopsis Proteins. Plant Physiol 2006 Aug;141(4):139-99
Tensin2 protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases. Mamm Genome 2006 May;17(5):407-16
alphabet protein, Drosophila  EC 3.1.3.16   *Phosphoprotein Phosphatases *Drosophila Proteins. Dev Biol 2006 Jun 1;294(1):232-45
Ptenb protein, zebrafish  EC 3.1.3.16   *Zebrafish Proteins *Phosphoprotein Phosphatases Tumor Suppressor Proteins. Dev Dyn 2005 Dec;234(4):911-21
Ptena protein, zebrafish  EC 3.1.3.16   *Phosphoprotein Phosphatases *Zebrafish Proteins Tumor Suppressor Proteins. Dev Dyn 2005 Dec;234(4):911-21
YbiV protein, E coli  EC 3.1.3.16   *Phosphoprotein Phosphatases *Escherichia coli Proteins. Proteins 2005 Mar 1;58(4):790-801
X17c protein, Xenopus  EC 3.1.3.-   *Phosphoprotein Phosphatases *Xenopus Proteins. Immunol Lett 2006 Apr 15;104(1-2):138-45
CPL2 protein, Arabidopsis  EC 3.1.3.16   *Phosphoprotein Phosphatases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2004 Oct 5;101(40):14539-44
TAP42 protein, Drosophila  EC 3.1.3.16   *Phosphoprotein Phosphatases *Drosophila Proteins Protein Subunits. Genetics 2005 Jun;170(2):733-40
CDC14 protein, S pombe  EC 3.1.3.16   *Phosphoprotein Phosphatases *Schizosaccharomyces pombe Proteins. Mol Biol Cell 1993 May;4(5):531-9
SixA protein, E coli  EC 3.1.3.16   *Phosphoprotein Phosphatases *Escherichia coli Proteins. Genes Cells 2005 Jan;10(1):1-11
PPG1 protein, S cerevisiae  EC 3.1.3.16   *Phosphoprotein Phosphatases *Saccharomyces cerevisiae Proteins. Biochem J 2005 Feb 15;386(Pt 1):93-102
PPH3 protein, S cerevisiae  EC 3.1.3.16   *Phosphoprotein Phosphatases *Saccharomyces cerevisiae Proteins. Biochem J 2005 Feb 15;386(Pt 1):93-102
Dis2 protein, S pombe  EC 3.1.3.16   *Phosphoprotein Phosphatases *Schizosaccharomyces pombe Proteins. EMBO J 2004 Feb 25;23(4):908-18
UBLCP1 protein, human  EC 3.1.3.16   *Nuclear Proteins *Phosphoprotein Phosphatases. Biochem Biophys Res Commun 2005 Jun 17;331(4):1401-7
Tns3 protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases src Homology Domains. Dev Biol 2005 Mar 15;279(2):368-17
CTDNEP1 protein, human  EC 3.1.3.16   *Phosphoprotein Phosphatases.
PAPP5 protein, Arabidopsis  EC 3.1.3.16   *Phosphoprotein Phosphatases *Arabidopsis Proteins. Cell 2005 Feb 11;120(3):395-406
PDXP protein, human  EC 3.1.3.16   *Phosphoprotein Phosphatases. Nat Cell Biol 2005 Jan;7(1);21-9
Rdg7 protein, Plasmodium falciparum  EC 3.1.3.16   *Phosphoprotein Phosphatases. BMC Mol Biol 2004 Jul 1;5(1):6
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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