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Adaptor Proteins, Signal Transducing

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Definition: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes     
Examples A Kinase Anchor Proteins; CARD Signaling Adaptor Proteins; Caveolin 1; Caveolin 2; Cortactin; Crk-Associated Substrate Protein; Death Domain Receptor Signaling Adaptor Proteins; GRB2 Adaptor Protein; GRB7 Adaptor Protein; GRB10 Adaptor Protein; Insulin Receptor Substrate Proteins; Interferon Regulatory Factors; Interferon-Stimulated Gene Factor 3; Mediator Complex; Myeloid Differentiation Factor 88; Nod Signaling Adaptor Proteins; Nuclear Receptor Coactivators; Paxillin; PII Nitrogen Regulatory Proteins; Protein Inhibitors of Activated STAT; 14-3-3 Proteins; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-vav; Retinoblastoma Binding Proteins; Shc Signaling Adaptor Proteins; Smad Proteins; STAT Transcription Factors; Suppressor of Cytokine Signaling Proteins; Syntenins; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 		Other names Signal Transducing Adaptor Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
WIF1 protein, zebrafish  0   *Repressor Proteins *Zebrafish Proteins *Adaptor Proteins, Signal Transducing. Biochim Biophys Acta. 2012 Feb;1823(2):236-44
NUP98-PSIP1 fusion protein, human  0   *Oncogene Proteins, Fusion *Nuclear Pore Complex Proteins *Adaptor Proteins, Signal Transducing Transcription Factors. Leuk Res. 2011 Jun;35(6):e75-6.
late endosome-lysosome membrane adaptor p18, mouse  0   *Adaptor Proteins, Signal Transducing. Biochem Biophys Res Commun. 2012 Jan 27;417(4):1151-7.
EHD protein-binding protein 1, Drosophila  0   *Drosophila Proteins *Adaptor Proteins, Signal Transducing. J Cell Biol. 2012 Jan 9;196(1):65-83.
PRAS40 protein, Drosophila  0   *Drosophila Proteins *Adaptor Proteins, Signal Transducing. Dev Cell. 2012 Jan 17;22(1):172-82
Dlgh1 protein, human  0   *Adaptor Proteins, Signal Transducing. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1625-30
Abl interactor 1 protein, human  0   *Adaptor Proteins, Signal Transducing. Biochem J. 2012 Feb 1;441(3):889-99
FAM123A protein, human  0   *Tumor Suppressor Proteins *Adaptor Proteins, Signal Transducing. J Biol Chem. 2012 Jan 13;287(3):1734-41
SCIMP protein, human  0   *Membrane Proteins *Adaptor Proteins, Signal Transducing. Mol Cell Biol. 2011 Nov;31(22):4550-62.
complexin 3 protein, human  0   *Adaptor Proteins, Signal Transducing. Nat Struct Mol Biol 2011 Aug;18(8):941-6
liprin-alpha1 protein, rat  0   *Adaptor Proteins, Signal Transducing. Synapse. 2011 Aug;65(8):742-50
arouser protein, Drosophila  0   *Arabidopsis Proteins *Adaptor Proteins, Signal Transducing. Neuron 2011 Jun 9;70(5):979-90
AFAP1L1 protein, human  0   *Microfilament Proteins *Adaptor Proteins, Signal Transducing. Eur J Cell Biol 2011 May;90(5):376-89
KCASH2 protein, human  0   *Adaptor Proteins, Signal Transducing. Neoplasia 2011 Apr;13(4):374-85
KCASH3 protein, human  0   *Adaptor Proteins, Signal Transducing. Neoplasia 2011 Apr;13(4):374-85
ECSIT protein, mouse  0   *Adaptor Proteins, Signal Transducing. Nature. 2011 Apr 28;472(7344):476-80
Prickle1a protein, zebrafish  0   *Zebrafish Proteins *Adaptor Proteins, Signal Transducing *LIM Domain Proteins.
caskin protein, Drosophila  0   *Nerve Tissue Proteins *Drosophila Proteins *Adaptor Proteins, Signal Transducing. J Neurosci. 2011 Mar 23;31(12):4421-33
Odin protein, human  0   *Adaptor Proteins, Signal Transducing. Oncogene 2002 Nov 14;21(52):8029-36
Par6B protein, human  0   *Adaptor Proteins, Signal Transducing. Mol Biol Cell 2010 Sep;21(17):2996-3006
CHB-3 protein, C elegans  0   *Caenorhabditis elegans Proteins *Adaptor Proteins, Signal Transducing Ankyrin Repeat. PLoS Genet 2010;6(11):e1001211
Spg21 protein, mouse  0   *Adaptor Proteins, Signal Transducing. Neurogenetics 2010 Oct;11(4):369-78
Abi1 protein, rat  0   *Adaptor Proteins, Signal Transducing. Mol Psychiatry 2010 Oct;15(10):976-86
mapk8ip3 protein, rat  0   *Nerve Tissue Proteins *Adaptor Proteins, Signal Transducing. Alcohol. 2010 Sep;44(6):477-85
COMMD7 protein, human  0   *Adaptor Proteins, Signal Transducing. Hepatogastroenterology. 2010 Jul-Aug;57(101):919-25
MzrA protein, E coli  0   *Escherichia coli Proteins *Adaptor Proteins, Signal Transducing. J Bacteriol 2010 Dec;192(23):6271-8
p37 protein, human  0   *Adaptor Proteins, Signal Transducing. Biochem Biophys Res Commun 2010 Nov 5;402(1):37-41
Appl1 protein, Xenopus  0   *Xenopus Proteins *Adaptor Proteins, Signal Transducing. Dev Dyn 2010 Aug;239(8):2198-207
TIRAP protein, zebrafish  0   *Zebrafish Proteins *Adaptor Proteins, Signal Transducing. J Immunol 2010 Sep 15;185(6):3391-400
AMBRA1 protein, human  0   *Adaptor Proteins, Signal Transducing. J Cell Biol 2010 Oct 4;191(1):155-68
DOK6 protein, mouse  0   *Adaptor Proteins, Signal Transducing Phosphoproteins. BMC Biol 2010;8:96
fibroblast receptor substrate 2, rat  0   *Adaptor Proteins, Signal Transducing. J Neurosci Res 2010 Jul;88(9):1882-9
Dok-7 protein, zebrafish  0   *Zebrafish Proteins *Adaptor Proteins, Signal Transducing. Hum Mol Genet 2010 May 1;19(9):1726-40
SH2D4B protein, human  0   *Adaptor Proteins, Signal Transducing. Immunol Rev 2009 Nov;232(1):240-54
COMMD1 protein, rat  0   *Adaptor Proteins, Signal Transducing. Am J Physiol Renal Physiol 2010 Jun;298(6):F1445-56
Dab1 protein, zebrafish  0   *Zebrafish Proteins *Adaptor Proteins, Signal Transducing. Comp Biochem Physiol B Biochem Mol Biol. 2010 Mar;155(3):217-29
ACBD5 protein, human  0   *Membrane Proteins *Adaptor Proteins, Signal Transducing. Thyroid. 2010 Jan;20(1):43-9
Bcl9 protein, Xenopus  0   *Xenopus Proteins *Adaptor Proteins, Signal Transducing. Dev Dyn 2010 Jan;239(1):271-83
ARP protein, Xenopus  0   *Xenopus Proteins *Adaptor Proteins, Signal Transducing. Dev Dyn 2010 Jan;239(1):261-70
Tks4 protein, human  0   *Adaptor Proteins, Signal Transducing. Am J Hum Genet 2010 Feb 12;86(2):254-61
Pik3ap1 protein, rat  0   *Adaptor Proteins, Signal Transducing.
KLHL18 protein, Drosophila  0   *Drosophila Proteins *Adaptor Proteins, Signal Transducing. Genes Cells 2009 Aug;14(8):965-73
2810453I06Rik protein, mouse  0   *Nuclear Proteins *Adaptor Proteins, Signal Transducing. Int J Urol. 2009 Jul;16(7):639-46
ARL6IP protein, rat  0   *Membrane Proteins *Adaptor Proteins, Signal Transducing. Bioorg Med Chem. 2009 Sep 1;17(17):6188-95
Lnk protein, Drosophila  0   *Drosophila Proteins *Adaptor Proteins, Signal Transducing. PLoS Genet 2009 Aug;5(8):e1000596
Elmo2 protein, mouse  0   *Cytoskeletal Proteins *Adaptor Proteins, Signal Transducing. Cell 2001 Oct 5;107(1):27-41
rabconnectin-3 protein, Drosophila  0   *Drosophila Proteins *Adaptor Proteins, Signal Transducing. Dev Cell. 2009 Sep;17(3); 387-402
Epg-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Adaptor Proteins, Signal Transducing. Autophagy 2009 Jul;5(5):608-15
UBXN-5 protein, C elegans  0   *Caenorhabditis elegans Proteins *Adaptor Proteins, Signal Transducing. Biochem Biophys Res Commun 2009 Sep 4;386(4):575-81
Morg1 protein, human  0   *Adaptor Proteins, Signal Transducing. Neurosci Lett 2009 May 8;455(1):46-50
Asb2 protein, mouse  0   *Adaptor Proteins, Signal Transducing. Cell Death Differ 2009 Jun;16(6):921-32
SPIN90 protein, mouse  0   *Nerve Tissue Proteins *Adaptor Proteins, Signal Transducing. J Neurochem 2009 May;109(4):1106-17
ABI3 protein, human  0   *Adaptor Proteins, Signal Transducing. Biochim Biophys Acta 2000 Sep 7;1493(1-2):237-41
ZFYVE28 protein, human  0   *Membrane Proteins *Adaptor Proteins, Signal Transducing Zinc Fingers. Dev Cell 2009 May;16(5):687-98
TTP protein, mouse  0   *Adaptor Proteins, Signal Transducing. J Biochem. 2009 Mar;145(3):403-9
Rcn2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Adaptor Proteins, Signal Transducing. Mol Cell Biol 2009 May;29(10):2777-93
BABAM1 protein, human  0   *Adaptor Proteins, Signal Transducing DNA Repair. Genes Dev 2009 Mar 15;23(6):719-28
lipid raft adaptor p18 protein, rat  0   *Adaptor Proteins, Signal Transducing. EMBO J 2009 Mar 4;28(5):477-89
lipid raft adaptor p18 protein, mouse  0   *Adaptor Proteins, Signal Transducing. EMBO J 2009 Mar 4;28(5):477-89
Arl6ip protein, zebrafish  0   *Zebrafish Proteins *Adaptor Proteins, Signal Transducing. Dev Dyn 2009 Jan;238(1):232-40
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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