Definition: A family of structurally related proteins that are constitutively expressed and that negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. PIAS proteins inhibit the activity of signal transducers and activators of transcription.
Other names PIAS4 Protein Inhibitor of Activated STAT; PIAS3 Protein Inhibitor of Activated STAT; PIAS2 Protein Inhibitor of Activated STAT; PIAS1 Protein; PIAS Proteins; PIAS1 Protein Inhibitor of Activated STAT