Definition: Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.
Other names p130 Crk Associated Substrate; Substrate, p130 Crk-Associated; Substrate Protein, Crk-Associated; Crk-Associated Substrate, p130; Crk Associated Substrate Protein; Crk Associated Substrate; Cas Protein, p130; Breast Cancer Anti Estrogen Resistance 1 Protein; p130Cas Protein; p130 Crk-Associated Substrate; p130 Cas Protein; Crk-Associated Substrate; CKRAS Protein; Breast Cancer Anti-Estrogen Resistance 1 Protein; BCAR1 Protein
