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DNA Repair

More information in Books or onNLM PubMed
Definition: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.  coord IM with specific DNA (IM)   
See Also Pyrimidine Dimers
Examples DNA End-Joining Repair; DNA Mismatch Repair; Recombinational DNA Repair; SOS Response (Genetics) 		Other names Nucleotide Excision Repair; Repairs, Base Excision; Repair, Excision; Repair, Base Excision; Nucleotide Excision Repairs; Excision Repairs; Excision Repair, Nucleotide; Excision Repair, Base; Base Excision Repairs; Excision Repair; Base Excision Repair
 
SubstanceCAS Registry & nameCategoriesSource
Shu1 protein, S cerevisiae  0   *Nuclear Proteins *Saccharomyces cerevisiae Proteins DNA Repair Protein Subunits. Mol Biol Cell 2011 May;22(9):1599-607
iduna protein, human  EC 6.3.2.19   *Ubiquitin-Protein Ligases DNA Repair. Proc Natl Acad Sci U S A 2011 Aug 23;108(34):14103-8
WRN protein, rat  EC 3.6.1.-   *DNA Helicases DNA Repair Werner Syndrome. J Cell Biol 1999 Jan 11;144(1):1-9
Mms1 protein, S pombe  0   *DNA-Binding Proteins *Schizosaccharomyces pombe Proteins DNA Repair. DNA Repair (Amst) 2011 Mar 7;10(3):283-95
RAD51D protein, Arabidopsis  0   *Repressor Proteins *Arabidopsis Proteins DNA Repair. Cell Host MIcrobe 2011 Feb 17;9(2):115-24
SSN2 protein, Arabidopsis  0   *Repressor Proteins *Arabidopsis Proteins DNA Repair. Cell Host MIcrobe 2011 Feb 17;9(2):115-24
Mei5 protein, human  0   *Nuclear Proteins DNA Repair. J Biol Chem 2011 Mar 18;286(11):9888-93
Swi5 protein, human  0   *Nuclear Proteins DNA Repair. J Biol Chem 2011 Mar 18;286(11):9888-93
BRCC36B protein, Arabidopsis  0   *Arabidopsis Proteins DNA Repair. Nucleic Acids Res 2011 Jan 1;39(1):146-54
BRCC36A protein, Arabidopsis  0   *Arabidopsis Proteins DNA Repair. Nucleic Acids Res 2011 Jan 1;39(1):146-54
XPA protein, rat  0   *DNA-Binding Proteins DNA Repair Xeroderma Pigmentosum. J Biol Chem 1997 Mar 7;272(10):6561-6
MMS22L protein, human  0   *DNA-Binding Proteins *Nuclear Proteins DNA Repair. Mol Cell 2010 Nov 24;40(4):619-31
FAN1 protein, human  EC 3.1.-   *Exodeoxyribonucleases DNA Repair. Mol Cell 2010 Jul 9;39(1):36-47
ALKBH8 protein, mouse  EC 2.1.1.-   *tRNA Methyltransferases DNA Repair. Mol Cell Biol 2010 Apr;30(7):1814-25
MSL1 protein, human  EC 2.3.1.48   *Histone Acetyltransferases DNA Repair Protein Subunits. J Cell Physiol 2009 Dec;221(3):594-602
SLX1 protein, human  EC 3.1.-   *Endonucleases DNA Repair. Cell 2009 Jul 10;138(1):78-89
Rrp2 protein, S pombe  0   *DNA-Binding Proteins *Schizosaccharomyces pombe Proteins DNA Repair. DNA Repair (Amst) 2009 May 1;8(5):627-36
Rrp1 protein, S pombe  0   *DNA-Binding Proteins *Schizosaccharomyces pombe Proteins DNA Repair. DNA Repair (Amst) 2009 May 1;8(5):627-36
HC1 protein, human  0   *DNA-Binding Proteins DNA Repair. Genet Mol Res 2009;8(1):247-60
BABAM1 protein, human  0   *Adaptor Proteins, Signal Transducing DNA Repair. Genes Dev 2009 Mar 15;23(6):719-28
XPC protein, rat  0   *Carrier Proteins DNA Repair. J Mol Histol 2008 Dec;39(6):617-25
RMI1 protein, Arabidopsis  0   *Carrier Proteins *Arabidopsis Proteins DNA Repair. PLoS Geneet 2008 Dec;4(12):e1000285
Tex15 protein, mouse  0   *Carrier Proteins DNA Repair. J Cell Biol 2008 Feb 25;180(4):673-9
Rad18 protein, rat  0   *DNA-Binding Proteins DNA Repair Zinc Fingers. Eur J Neurosci 2007 Nov;26(9):2444-57
Tim1 protein, Xenopus  0   *Carrier Proteins *Xenopus Proteins DNA Repair. Proc Natl Acad Sci U S A 2007 Sep 18;104(38):14929-34
tipin protein, Xenopus  0   *Carrier Proteins *Xenopus Proteins DNA Repair Phosphoproteins. Proc Natl Acad Sci U S A 2007 Sep 18;104(38):14929-34
MLH1 protein, Arabidopsis  EC 3.6.1.-   *Adenosine Triphosphatases *Arabidopsis Proteins DNA Repair. Mol Gen Genet 1999 Dec;262(4-5):633-42
SPF45 protein, Drosophila  0   *Ribonucleoprotein, U2 Small Nuclear *Drosophila Proteins DNA Repair. PLoS Genet 2006 Dec 8;2(12):e178
XLF protein, mouse  0   *DNA-Binding Proteins DNA Repair. Proc Natl Acad Sci U S A 2007 Mar 13;104(11):4518-23
Mei-P22 protein, Drosophila  0   *Chromosomal Proteins, Non-Histone *Drosophila Proteins DNA Repair. PLoS Genet 2006 Nov 24;2(11):e200
SPO11-2 protein, Arabidopsis  EC 5.99.1.-   *DNA Topoisomerases *Arabidopsis Proteins DNA Repair Protein Subunits. Nucleic Acids Res 2000 Apr 1;28(7):1548-54
Nbs protein, Drosophila  0   *Carrier Proteins *Drosophila Proteins DNA Repair. Genetics 2006 Jul;173(3):1447-54
MUS81 protein, Arabidopsis  EC 3.1.-   *Endonucleases *Arabidopsis Proteins DNA Repair. Nucleic Acids Res 2006;34(16):4438-48
MND1 protein, Arabidopsis  0   *Arabidopsis Proteins DNA Repair. J Cell Sci 2006 Jun 15;119(Pt 12):2486-96
RAD4 protein, Arabidopsis  0   *DNA-Binding Proteins *Arabidopsis Proteins DNA Repair. Plant Mol Biol 2006 May;61(1-2):345-56
GTF2H5 protein, human  0   *Transcription Factors DNA Repair. PLoS Biol 2006 Jun;4(6):e156
GTF2H2 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins DNA Repair Protein Subunits. Plant J 2006 May;46(3):512-21
Nbs1 protein, Xenopus  0   *Tumor Suppressor Proteins *Xenopus Proteins DNA Repair DNA-Binding Proteins. Mol Cell Biol 2005 Jul;25(3):5363-79
Msh6 protein, C elegans  0   *DNA-Binding Proteins *Caenorhabditis elegans Proteins DNA Repair Base Pair Mismatch. Genetics 2005 May;170(1):107-13
SETMAR protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase DNA Repair. Proc Natl Acad Sci U S A 2005 Dec 13;102(50):18075-80
NHEJ1 protein, human  0   *DNA-Binding Proteins *DNA Repair Enzymes DNA Repair. Cell 2006 Jan 27;124(2):287-9
SLX1 protein, S cerevisiae  EC 3.1.-   *Endodeoxyribonucleases *Saccharomyces cerevisiae Proteins DNA Repair. Biochem J 2005 Oct 15;391(Pt 2):325-33
Ogg1 protein, S cerevisiae  EC 3.2.2.-   *Saccharomyces cerevisiae Proteins *DNA Glycosylases DNA Repair. Proc Natl Acad Sci U S A 2005 Sep 20;102(38):13538-43
RAD51B protein, Arabidopsis  0   *Arabidopsis Proteins DNA Repair. Plant Mol Biol 2005 Apr;57(6):819-33
NSMCE2 protein, human  EC 6.3.2.-   *Ligases DNA Repair. Mol Cell Biol 2005 Aug;25(16):7021-32
XAB2 protein, mouse  0   *Carrier Proteins DNA Repair RNA Splicing. DNA Repair (Amst) 2005 Apr 4;4(4):479-91
Msh4 protein, mouse  0   *Cell Cycle Proteins DNA Repair Meiosis.
alkyltransferase-like protein, E coli  EC 2.5.1.-   *Alkyl and Aryl Transferases *Escherichia coli Proteins DNA Repair. Nucleic Acids Res. 2005;33(12) (dup#5):3837-44
Qri2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins DNA Repair. Mol Microbiol 2005 Mar;55(6):1735-50
MLH1 protein, human  0   *Nuclear Proteins *Adaptor Proteins, Signal Transducing DNA Repair DNA Repair Enzymes.
Mlh1 protein, rat  0   *Nuclear Proteins *Adaptor Proteins, Signal Transducing DNA Repair.
RAD17 protein, Arabidopsis  0   *Cell Cycle Proteins *Arabidopsis Proteins DNA Repair.
RSC1 protein, S cerevisiae  0   *Chromosomal Proteins, Non-Histone *Saccharomyces cerevisiae Proteins DNA Repair. Mol Cell Biol 2005 May;25(10):3934-44
Xpc protein, mouse  0   *DNA-Binding Proteins DNA Repair.
MutLalpha protein, human  0   *DNA Repair Enzymes DNA Repair Base Pair Mismatch. Mol Carcinog 2005 May;43(1):51-8
BRC-2 protein, C elegans  0   *DNA-Binding Proteins DNA Repair. Mol Cell Biol 2005 Apr;25(8):3127-39
XPB2 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins DNA Repair. Plant J 2001 Nov;28(4):385-95
MSH7 protein, Arabidopsis  0   *Arabidopsis Proteins DNA Repair Base Pair Mismatch.
Pms2 protein, mouse  EC 3.6.1.-   *Adenosine Triphosphatases *DNA-Binding Proteins *DNA Repair Enzymes DNA Repair Neoplasm Proteins Base Pair Mismatch.
Ercc1 protein, mouse  EC 3.1.-   *DNA-Binding Proteins *Endonucleases DNA Repair.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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