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DNA Topoisomerases

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Definition: Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.     
Examples DNA Topoisomerases, Type I; DNA Topoisomerases, Type II 		Other names Topoisomerases, DNA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RDH54 protein, S cerevisiae  EC 5.99.1.-   *DNA Helicases *DNA Topoisomerases.
SPO11-3 protein, Arabidopsis  EC 5.99.1.-   *DNA Topoisomerases *Arabidopsis Proteins Protein Subunits. Gene 2001 Jun 13;271(1):81-6
SPO11-2 protein, Arabidopsis  EC 5.99.1.-   *DNA Topoisomerases *Arabidopsis Proteins DNA Repair Protein Subunits. Nucleic Acids Res 2000 Apr 1;28(7):1548-54

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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